Novel role of cholesteryl ester transfer protein (CETP): attenuation of adiposity by enhancing lipolysis and brown adipose tissue activity
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Citações na Scopus
7
Tipo de produção
article
Data de publicação
2021
Título da Revista
ISSN da Revista
Título do Volume
Editora
W B SAUNDERS CO-ELSEVIER INC
Autores
RAPOSO, Helena F.
FORSYTHE, Patricia
CHAUSSE, Bruno
CASTELLI, Julia Z.
MORAES-VIEIRA, Pedro M.
OLIVEIRA, Helena C. F.
Citação
METABOLISM-CLINICAL AND EXPERIMENTAL, v.114, article ID 154429, 14p, 2021
Resumo
Objective: The systemic function of CETP has been well characterized. CETP plasma activity reduces HDL cholesterol and thus increases the risk of atherosclerosis. Here, we investigated whether CETP expression modulate adiposity. Methods: Body adiposity and energy metabolism related assays and gene/protein expression were compared in CETP transgenic and non-transgenic mice and in hamsters treated with CETP neutralizing antibody. Results: We found that transgenic mice expressing human CETP present less white adipose tissue mass and lower leptinemia than nontransgenic (NTg) littermates. No differences were found in physical activity, food intake, fat fecal excretion, lipogenesis or exogenous lipid accumulation in adipose depots. Nonetheless, adipose lipolysis rates and whole-body energy expenditure were elevated in CETP mice. In accordance, lipolysis-related gene expression and protein content were increased in visceral and brown adipose tissue (BAT). In addition, we verified increased BAT temperature and oxygen consumption. These results were confirmed in two other animal models: 1) hamsters treated with CETP neutralizing antibody and 2) an independent line of transgenic mice expressing simian CETP. Conclusions: These findings reveal a novel anti-adipogenic role for CETP.
Palavras-chave
CETP, Adiposity, Lipolysis, Oxygen consumption, Brown adipose tissue
Referências
- Agha G, 2015, INT J EPIDEMIOL, V44, P1277, DOI 10.1093/ije/dyu236
- Akbarzadeh M, 2012, MOL BIOL REP, V39, P9529, DOI 10.1007/s11033-012-1817-3
- Ashrafi K, 2003, NATURE, V421, P268, DOI 10.1038/nature01279
- Barter PJ, 2007, NEW ENGL J MED, V357, P2109, DOI 10.1056/NEJMoa0706628
- Benoist F, 1997, J BIOL CHEM, V272, P23572, DOI 10.1074/jbc.272.38.23572
- Benton MC, 2015, GENOME BIOL, V16, DOI 10.1186/s13059-014-0569-x
- Broeders EPM, 2015, CELL METAB, V22, P418, DOI 10.1016/j.cmet.2015.07.002
- Cannon B, 2011, J EXP BIOL, V214, P242, DOI 10.1242/jeb.050989
- Cappel DA, 2013, MOL METAB, V2, P457, DOI 10.1016/j.molmet.2013.08.007
- Cazita PM, 2008, SHOCK, V30, P590, DOI 10.1097/SHK.0b013e31816e30fd
- Cherezov V, 2007, SCIENCE, V318, P1258, DOI 10.1126/science.1150577
- Cortes-Martin A, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-64833-4
- DRAYNA D, 1987, NATURE, V327, P632, DOI 10.1038/327632a0
- Ferrante AW, 2013, DIABETES OBES METAB, V15, P34, DOI 10.1111/dom.12154
- HA YC, 1982, COMP BIOCHEM PHYS B, V71, P265, DOI 10.1016/0305-0491(82)90252-8
- Haas JT, 2015, HEPATOLOGY, V62, P1659, DOI 10.1002/hep.28125
- Harada LM, 2007, ATHEROSCLEROSIS, V191, P313, DOI 10.1016/j.atherosclerosis.2006.05.036
- Hildebrandt AL, 2002, J PHARMACOL TOXICOL, V47, P99, DOI 10.1016/S1056-8719(02)00208-3
- Holm C, 2003, BIOCHEM SOC T, V31, P1120, DOI 10.1042/BST0311120
- HPS3 TIMI55-REVEAl Collaborative, 2017, NEW ENGL J MED, V377, P1217, DOI 10.1056/NEJMoa1706444
- Hutter E, 2006, EXP GERONTOL, V41, P103, DOI 10.1016/j.exger.2005.09.011
- Izem L, 2015, J LIPID RES, V56, P515, DOI 10.1194/jlr.M053678
- JIANG XC, 1992, J CLIN INVEST, V90, P1290, DOI 10.1172/JCI115993
- Johansson LE, 2012, AM J CLIN NUTR, V96, P196, DOI 10.3945/ajcn.111.020578
- Langin D, 2006, PHARMACOL RES, V53, P482, DOI 10.1016/j.phrs.2006.03.009
- Le Lay S, 2001, J BIOL CHEM, V276, P16904, DOI 10.1074/jbc.M010955200
- Lee HJ, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-20809-z
- Li YH, 2014, LIPIDS HEALTH DIS, V13, DOI 10.1186/1476-511X-13-136
- Lincoff AM, 2017, NEW ENGL J MED, V376, P1933, DOI 10.1056/NEJMoa1609581
- Magdalon J, 2016, BBA-MOL CELL BIOL L, V1861, P430, DOI 10.1016/j.bbalip.2016.02.023
- MAROTTI KR, 1993, NATURE, V364, P73, DOI 10.1038/364073a0
- Masschelin PM, 2020, FRONT PHYSIOL, V10, DOI 10.3389/fphys.2019.01638
- Moraes-Vieira PM, 2016, DIABETES, V65, P1317, DOI 10.2337/db15-1696
- Navarro CDC, 2017, FREE RADICAL BIO MED, V113, P190, DOI 10.1016/j.freeradbiomed.2017.09.026
- Nicholson A, 2010, OBESITY, V18, P1902, DOI 10.1038/oby.2009.477
- Nunes VS, 2011, CLIN CHIM ACTA, V412, P176, DOI 10.1016/j.cca.2010.09.039
- Oliveira HCF, 1997, ARTERIOSCL THROM VAS, V17, P1045, DOI 10.1161/01.ATV.17.6.1045
- Oliveira HCF, 2020, ADV EXP MED BIOL, V1276, P15, DOI 10.1007/978-981-15-6082-8_2
- Oliveira HCF, 2011, IUBMB LIFE, V63, P248, DOI 10.1002/iub.448
- OSONO Y, 1995, J CLIN INVEST, V95, P1124, DOI 10.1172/JCI117760
- Osuga J, 2000, P NATL ACAD SCI USA, V97, P787, DOI 10.1073/pnas.97.2.787
- Radeau T, 1995, J LIPID RES, V36, P2552
- Raposo HF, 2016, LIPIDS HEALTH DIS, V15, DOI 10.1186/s12944-016-0179-6
- Raposo HF, 2015, NUTR METAB, V12, DOI 10.1186/s12986-015-0058-6
- Rautureau Y, 2018, CIRCULATION, V138, P1677, DOI 10.1161/CIRCULATIONAHA.117.031134
- RODBELL M, 1964, J BIOL CHEM, V239, P375
- SAGGERSON ED, 1988, BIOCHEM J, V251, P701, DOI 10.1042/bj2510701
- Salerno AG, 2007, INT J OBESITY, V31, P1586, DOI 10.1038/sj.ijo.0803646
- Salerno AG, 2019, BIOCHEM J, V476, P3769, DOI 10.1042/BCJ20190543
- Schwartz GG, 2012, NEW ENGL J MED, V367, P2089, DOI 10.1056/NEJMoa1206797
- Shabalina IG, 2010, BBA-BIOENERGETICS, V1797, P773, DOI 10.1016/j.bbabio.2010.04.007
- SHEPHERD D, 1969, BIOCHEM J, V114, P597, DOI 10.1042/bj1140597
- TAKAHASHI K, 1993, J CLIN INVEST, V92, P2060, DOI 10.1172/JCI116802
- Talbot CPJ, 2018, ATHEROSCLEROSIS, V274, P23, DOI 10.1016/j.atherosclerosis.2018.04.029
- TALL AR, 1993, J LIPID RES, V34, P1255
- Teran-Garcia M, 2008, ATHEROSCLEROSIS, V196, P455, DOI 10.1016/j.atherosclerosis.2006.12.005
- Toye AA, 2005, DIABETOLOGIA, V48, P675, DOI 10.1007/s00125-005-1680-z
- Tsutsumi K, 2001, BIOL PHARM BULL, V24, P579, DOI 10.1248/bpb.24.579
- VAUGHAN M, 1962, J BIOL CHEM, V237, P3354
- Wang JL, 2012, ATHEROSCLEROSIS, V223, P342, DOI 10.1016/j.atherosclerosis.2012.06.003
- Watanabe M, 2006, NATURE, V439, P484, DOI 10.1038/nature04330
- Yao ZP, 2005, ANAL BIOCHEM, V343, P344, DOI 10.1016/j.ab.2005.05.002
- ZHAO J, 1994, AM J PHYSIOL-CELL PH, V267, pC969
- Zhou HW, 2006, J LIPID RES, V47, P2011, DOI 10.1194/jlr.M600153-JLR200