Polymorphisms in Genes Involved in Folate Metabolism Modify the Association of Dietary and Circulating Folate and Vitamin B-6 with Cervical Neoplasia

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art_VILLA_Polymorphisms_in_Genes_Involved_in_Folate_Metabolism_Modify_2013.PDF (561.05 KB)
Citações na Scopus
18
Tipo de produção
article
Data de publicação
2013
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
AMER SOC NUTRITION-ASN
Autores
TOMITA, Luciana Y.
D'ALMEIDA, Vania
FRANCO, Eduardo L.
CARDOSO, Marly A.
Citação
JOURNAL OF NUTRITION, v.143, n.12, p.2007-2014, 2013
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
High folate intake has been suggested as an important factor in cancer prevention; however, previous studies on the relation among folate intake, serum folate, and plasma homocysteine (hcy) are controversial. We conducted a hospital-based, case-control study in Brazil investigating associations between dietary and circulating vitamins B-6 and B-12 and folate, hcy, genotypes of folate-metabolizing enzyme methylenetetrahydrofolate reductase (MTHFR C677T, A1298C), 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR A2756G), methionine synthase reductase (MTRR A66G), and reduced folate carrier (RFC1 G80A) and risk of cervical intraepithelial neoplasia (CIN) grades 1 (CIN1), 2 (CIN2), and 3 (CIN3). The study was composed by 453 controls, 140 CIN1, 126 CIN2, and 231 CIN3. We investigated the joint effects of genetic variants of folate-related genes using genetic risk scores (GRSs) by summing the number of risk alleles for CIN1 and CIN2+ (CIN2 and CIN3 cases). The OR (95% CI) for CIN1 and CIN2+ per each risk allele were 1.29 (1.01, 1.65) and 1.22 (1.01, 1.46), respectively. An association between folate intake and CIN2+ was observed only after stratification according to GRS: crude OR (95% CI) for lower folate intake and GRS >= 4 was 1.67 (0.92, 3.04) (P-trend < 0.001) compared with higher folate intake (above the median) and GRS <= 3. The CIN2+ risk of lower serum vitamin B-6 and GRS >= 4 was 2.14 (0.92, 5.02) (P-trend = 0.05) and lower serum folate (below the median) and GRS >= 4 was 0.49 (0.20, 1.17) (P-trend = 0.05) after adjustment for confounding variables and human papillomavirus infection. Our data suggest that polymorphisrns in genes related to folate metabolism modify the association of dietary and circulating folate and vitamin B-6 with cervical neoplasia.
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URI
https://observatorio.fm.usp.br/handle/OPI/4014
Referências
  1. Alberg AJ, 2000, CANCER EPIDEM BIOMAR, V9, P761
  2. Barker J, 2011, J EUR ACAD DERMATOL, V25, P758, DOI 10.1111/j.1468-3083.2010.03932.x
  3. Berrington A, 2003, BIOSTATISTICS, V4, P423, DOI 10.1093/biostatistics/4.3.423
  4. BLOCK G, 1994, AM J EPIDEMIOL, V139, P1190
  5. Cardon LR, 2003, LANCET, V361, P598, DOI 10.1016/S0140-6736(03)12520-2
  6. Cardoso MA, 2010, CAD SAUDE PUBLICA, V26, P2059, DOI 10.1590/S0102-311X2010001100007
  7. Carmel R, 2006, MODERN NUTR HLTH DIS, P470
  8. Ferlay J, 2010, INT J CANCER, V127, P2893, DOI 10.1002/ijc.25516
  9. Flatley JE, 2009, CANCER EPIDEM BIOMAR, V18, P2782, DOI 10.1158/1055-9965.EPI-09-0493
  10. Fowler BM, 1998, CANCER EPIDEM BIOMAR, V7, P901
  11. Goodman MT, 2000, CANCER, V89, P376, DOI 10.1002/1097-0142(20000715)89:2<376::AID-CNCR24>3.0.CO;2-O
  12. Goodman MT, 2001, CANCER EPIDEM BIOMAR, V10, P1275
  13. Goring HHH, 2001, AM J HUM GENET, V69, P1357, DOI 10.1086/324471
  14. Guerra-Shinohara EM, 2002, BJOG-INT J OBSTET GY, V109, P784, DOI 10.1016/S1470-0328(02)01307-1
  15. Henao OL, 2005, INT J CANCER, V113, P991, DOI 10.1002/ijc.20695
  16. Hernandez BY, 2003, CANCER CAUSE CONTROL, V14, P859, DOI 10.1023/B:CACO.0000003841.54413.98
  17. Herrmann W, 2011, DTSCH ARZTEBL INT, V108, P249, DOI 10.3238/arztebl.2011.0249
  18. Isotalo PA, 2000, AM J HUM GENET, V67, P986, DOI 10.1086/303082
  19. Jorde LB, 2000, GENOME RES, V10, P1435, DOI 10.1101/gr.144500
  20. Kanetsky PA, 1998, NUTR CANCER, V31, P31
  21. Kim YI, 2000, NUTR REV, V58, P205
  22. Kjellberg L, 2000, BRIT J CANCER, V82, P1332
  23. Kleimbaum DG, 1998, LOGISTIC REGRESSION
  24. Knol MJ, 2007, INT J EPIDEMIOL, V36, P1111, DOI 10.1093/ije/dym157
  25. Kwasniewska A, 2002, EUR J GYNAECOL ONCOL, V23, P311
  26. Lambropoulos AF, 2003, CANCER LETT, V191, P187, DOI 10.1016/S0304-3835(02)00675-4
  27. Long SY, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0052381
  28. Luo YL, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0046272
  29. Mei Q, 2012, BMC CANCER, V12, DOI 10.1186/1471-2407-12-467
  30. Moreno V, 2002, LANCET, V359, P1085, DOI 10.1016/S0140-6736(02)08150-3
  31. Munoz N, 2003, NEW ENGL J MED, V348, P518, DOI 10.1056/NEJMoa021641
  32. Munoz N, 2002, LANCET, V359, P1093, DOI 10.1016/S0140-6736(02)08151-5
  33. Myakishev MV, 2001, GENOME RES, V11, P163, DOI 10.1101/gr.157901
  34. Parikh S, 2003, INT J CANCER, V105, P687, DOI 10.1002/ijc.11141
  35. Piyathilake CJ, 2009, CANCER PREV RES, V2, P658, DOI 10.1158/1940-6207.CAPR-08-0175
  36. Piyathilake Chandrika J, 2007, Ethn Dis, V17, pS2
  37. Plummer M, 2003, CANCER CAUSE CONTROL, V14, P805, DOI 10.1023/B:CACO.0000003811.98261.3e
  38. Rodriguez S, 2009, AM J EPIDEMIOL, V169, P505, DOI 10.1093/aje/kwn359
  39. Rozen R, 1997, THROMB HAEMOSTASIS, V78, P523
  40. Rusch TL, 2003, P SOC PHOTO-OPT INS, V4966, P138, DOI 10.1117/12.483474
  41. Sedjo RL, 2003, CANCER CAUSE CONTROL, V14, P319, DOI 10.1023/A:1023981505268
  42. Sedjo RL, 2003, NUTRITION, V19, P497, DOI 10.1016/S0899-9007(02)01096-1
  43. Shane B, 2008, FOOD NUTR B S2, V29, pS7
  44. Shane B, 2008, FOOD NUTR BULL, V29, pS5
  45. Shannon J, 2002, CANCER CAUSE CONTROL, V13, P691, DOI 10.1023/A:1020289618161
  46. SHARMA SK, 1992, J CHROMATOGR-BIOMED, V578, P45, DOI 10.1016/0378-4347(92)80223-D
  47. Shekari M, 2008, ARCH GYNECOL OBSTET, V278, P517, DOI 10.1007/s00404-008-0623-6
  48. Sohn KJ, 2009, INT J CANCER, V124, P1999, DOI 10.1002/ijc.24003
  49. Szklo M., 2000, EPIDEMIOLOGY BASICS
  50. Thomson SW, 2000, NUTR CANCER, V37, P128, DOI 10.1207/S15327914NC372_2
  51. Thomson SW, 2000, NUTRITION, V16, P411, DOI 10.1016/S0899-9007(00)00284-7
  52. Tomita LY, 2010, INT J CANCER, V126, P703, DOI 10.1002/ijc.24793
  53. Tong SY, 2011, CANCER CAUSE CONTROL, V22, P63, DOI 10.1007/s10552-010-9675-6
  54. Trumbo P, 2001, J AM DIET ASSOC, V101, P294, DOI 10.1016/S0002-8223(01)00078-5
  55. Ueland PM, 2001, TRENDS PHARMACOL SCI, V22, P195, DOI 10.1016/S0165-6147(00)01675-8
  56. VANEENWYK J, 1992, CANCER EPIDEM BIOMAR, V1, P119
  57. Walboomers JMM, 1999, J PATHOL, V189, P12, DOI 10.1002/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F
  58. Wang LN, 2006, EUR J CANCER, V42, P3206, DOI 10.1016/j.ejca.2006.04.022
  59. Weinstein SJ, 2001, CANCER CAUSE CONTROL, V12, P317, DOI 10.1023/A:1011290103779
  60. WHO, 2002, WHO TECHN REP SER, V916
  61. Wideroff L, 1998, NUTR CANCER, V30, P130
  62. Willett W., 1998, NUTR EPIDEMIOLOGY
  63. Yang QH, 2009, CANCER EPIDEM BIOMAR, V18, P1439, DOI 10.1158/1055-9965.EPI-08-0908
  64. Yeo ASS, 2000, NUTR CANCER, V38, P141, DOI 10.1207/S15327914NC382_1
  65. Ziegler RG, 2002, J NUTR, V132, p2345S

Coleções
Artigos e Materiais de Revistas Científicas - FM/MDR
Artigos e Materiais de Revistas Científicas - LIM/24
Artigos e Materiais de Revistas Científicas - ODS/03