Accuracy of frozen section in intraoperative margin assessment for breast-conserving surgery: A systematic review and meta-analysis

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art_GARCIA_Accuracy_of_frozen_section_in_intraoperative_margin_assessment_2021.PDF (1.68 MB)
Citações na Scopus
20
Tipo de produção
article
Data de publicação
2021
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
PUBLIC LIBRARY SCIENCE
Autores
CARDOSO, Natalia
MARTIMBIANCO, Ana Luiza Cabrera
Citação
PLOS ONE, v.16, n.3, article ID e0248768, 15p, 2021
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background and objectives It is well established that tumor-free margin is an important factor for reducing local recurrence and reoperation rates. This systematic review with meta-analysis of frozen section intraoperative margin assessment aims to evaluate the accuracy, and reoperation and survival rates, and to establish its importance in breast-conserving surgery. Methods A thorough review was conducted in all online publication-databases for the related literature up to March 2020. MeSH terms used: ""Breast Cancer"", ""Segmental Mastectomy"" and ""Frozen Section"". We included the studies that evaluated accuracy of frozen section, reoperation and survival rates. To ensure quality of the included articles, the QUADAS-2 tool (adapted) was employed. The assessment of publication bias by graphical and statistical methods was performed using the funnel plot and the Egger's test. The review protocol was registered in PROSPERO (CRD42019125682). Results Nineteen studies were deemed suitable, with a total of 6,769 cases. The reoperation rate on average was 5.9%. Sensitivity was 0.81, with a Confidence Interval of 0.79-0.83, p = 0.0000, I2 = 95.1%, and specificity was 0.97, with a Confidence Interval of 0.97-0.98, p = 0.0000, I-2 = 90.8%, for 17 studies and 5,615 cases. Accuracy was 0.98. Twelve studies described local recurrence and the highest cumulative recurrence rate in 3 years was 7.5%. The quality of the included studies based on the QUADAS-2 tool showed a low risk of bias. There is no publication bias (p = 0.32) and the funnel plot showed symmetry. Conclusion Frozen section is a reliable procedure with high accuracy, sensitivity and specificity in intraoperative margin assessment of breast-conserving surgery. Therefore, this modality of margin assessment could be useful in reducing reoperation rates.
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URI
https://observatorio.fm.usp.br/handle/OPI/40834
Referências
  1. Anila KR, 2016, INDIAN J CANCER, V53, P235, DOI 10.4103/0019-509X.197732
  2. [Anonymous], RevMan 5 download | Cochrane Training
  3. Boughey JC, 2014, SURGERY, V156, P190, DOI 10.1016/j.surg.2014.03.025
  4. Cabioglu N, 2007, ANN SURG ONCOL, V14, P1458, DOI 10.1245/s10434-006-9236-0
  5. Caruso F, 2011, EJSO-EUR J SURG ONC, V37, P871, DOI 10.1016/j.ejso.2011.07.002
  6. Cendan JC, 2005, J AM COLL SURGEONS, V201, P194, DOI 10.1016/j.jamcollsurg.2005.03.014
  7. Dener C, 2009, SCAND J SURG, V98, P34, DOI 10.1177/145749690909800107
  8. Fisher B, 2002, NEW ENGL J MED, V347, P1233, DOI 10.1056/NEJMoa022152
  9. Flasinski M, 2018, BLOOD ADV, V2, P1532, DOI 10.1182/bloodadvances.2018018945
  10. Gage I, 1996, CANCER-AM CANCER SOC, V78, P1921, DOI 10.1002/(SICI)1097-0142(19961101)78:9<1921::AID-CNCR12>3.0.CO;2-#
  11. Green S, COCHRANE HDB SYSTEMA
  12. Houssami N, 2014, ANN SURG ONCOL, V21, P717, DOI 10.1245/s10434-014-3480-5
  13. Ikeda T, 1997, SURG TODAY, V27, P207, DOI 10.1007/BF00941646
  14. JACOBSON JA, 1995, NEW ENGL J MED, V332, P907, DOI 10.1056/NEJM199504063321402
  15. Jorns JM, 2017, EJSO-EUR J SURG ONC, V43, P1273, DOI 10.1016/j.ejso.2017.01.237
  16. Jorns JM, 2014, AM J CLIN PATHOL, V142, P601, DOI 10.1309/AJCPRSOA2G8RLEXY
  17. Kikuyama M, 2015, JPN J CLIN ONCOL, V45, P19, DOI 10.1093/jjco/hyu158
  18. Kim MJ, 2016, BREAST CANCER-BASIC, V10, P205, DOI 10.4137/BCBCR.S40868
  19. Ko S, 2017, J BREAST CANCER, V20, P176, DOI 10.4048/jbc.2017.20.2.176
  20. Leong C, 2004, CANCER-AM CANCER SOC, V100, P1823, DOI 10.1002/cncr.20153
  21. Lurie RH., 2020, 2020 BREAST CANC
  22. Moher D, 2009, ANN INTERN MED, V151, P264, DOI 10.7326/0003-4819-151-4-200908180-00135
  23. Moran MS, 2014, INT J RADIAT ONCOL, V88, P553, DOI 10.1016/j.ijrobp.2013.11.012
  24. Morrow M, 2017, JAMA ONCOL, V3, P1352, DOI 10.1001/jamaoncol.2017.0774
  25. NOGUCHI M, 1995, J SURG ONCOL, V60, P185, DOI 10.1002/jso.2930600309
  26. Nowikiewicz T, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-49951-y
  27. Nunez A, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-74373-6
  28. Obedian E, 2000, CANCER J, V6, P28
  29. Olson TP, 2007, ANN SURG ONCOL, V14, P2953, DOI 10.1245/s10434-007-9437-1
  30. Osako T, 2015, INT J CLIN ONCOL, V20, P1093, DOI 10.1007/s10147-015-0827-2
  31. Pinotti JA, 2002, EUR J GYNAECOL ONCOL, V23, P11
  32. Poggi MM, 2003, CANCER, V98, P697, DOI 10.1002/cncr.11580
  33. Riedl O, 2009, EJSO-EUR J SURG ONC, V35, P264, DOI 10.1016/j.ejso.2008.05.007
  34. Rusby JE, 2008, AM J SURG, V196, P512, DOI 10.1016/j.amjsurg.2008.06.026
  35. SAUTER ER, 1994, CANCER-AM CANCER SOC, V73, P2607, DOI 10.1002/1097-0142(19940515)73:10<2607::AID-CNCR2820731023>3.0.CO;2-1
  36. SCHNITT SJ, 1994, CANCER, V74, P1746, DOI 10.1002/1097-0142(19940915)74:6<1746::AID-CNCR2820740617>3.0.CO;2-Y
  37. SMITT MC, 1995, CANCER-AM CANCER SOC, V76, P259, DOI 10.1002/1097-0142(19950715)76:2<259::AID-CNCR2820760216>3.0.CO;2-2
  38. St John ER, 2017, ANN SURG, V265, P300, DOI 10.1097/SLA.0000000000001897
  39. Taghian A, 2005, ANN SURG, V241, P629, DOI 10.1097/01.sla.0000157272.04803.1b
  40. Tan MP, 2014, INT J BREAST CANCER, V2014, DOI 10.1155/2014/715404
  41. Veronesi U, 2002, NEW ENGL J MED, V347, P1227, DOI 10.1056/NEJMoa020989
  42. Weber WP, 2008, WORLD J SURG, V32, P2599, DOI 10.1007/s00268-008-9757-8
  43. Weng EY, 2000, CANCER, V88, P1643, DOI 10.1002/(SICI)1097-0142(20000401)88:7<1643::AID-CNCR19>3.3.CO;2-F
  44. Whiting PF, 2011, ANN INTERN MED, V155, P529, DOI 10.7326/0003-4819-155-8-201110180-00009
  45. Wright MJ, 2007, J AM COLL SURGEONS, V204, P541, DOI 10.1016/j.jamcollsurg.2007.01.031
  46. Yang M, 2018, JAMA ONCOL, V4, P746, DOI 10.1001/jamaoncol.2017.5227

Coleções
Artigos e Materiais de Revistas Científicas - FM/MPT
Artigos e Materiais de Revistas Científicas - FM/MOG
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/14
Artigos e Materiais de Revistas Científicas - LIM/58
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