16th International Congress on Antiphospholipid Antibodies Task Force Report on Antiphospholipid Syndrome Treatment Trends

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art_COHEN_16th_International_Congress_on_Antiphospholipid_Antibodies_Task_Force_2020.PDF (759.48 KB)
Citações na Scopus
72
Tipo de produção
article
Data de publicação
2020
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
SAGE PUBLICATIONS LTD
Autores
COHEN, Hannah
CUADRADO, Maria J.
ERKAN, Doruk
DUARTE-GARCIA, Ali
ISENBERG, David A.
KNIGHT, Jason S.
ORTEL, Thomas L.
RAHMAN, Anisur
SALMON, Jane E.
TEKTONIDOU, Maria G.
Citação
LUPUS, v.29, n.12, p.1571-1593, 2020
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Antiphospholipid syndrome (APS), an acquired autoimmune thrombophilia, is characterised by thrombosis and/or pregnancy morbidity in association with persistent antiphospholipid antibodies. The 16th International Congress on Antiphospholipid Antibodies Task Force on APS Treatment Trends reviewed the current status with regard to existing and novel treatment trends for APS, which is the focus of this Task Force report. The report addresses current treatments and developments since the last report, on the use of direct oral anticoagulants in patients with APS, antiplatelet agents, adjunctive therapies (hydroxychloroquine, statins and vitamin D), targeted treatment including rituximab, belimumab, and anti-TNF agents, complement inhibition and drugs based on peptides of beta-2-glycoprotein I. In addition, the report summarises potential new players, including coenzyme Q10, adenosine receptor agonists and adenosine potentiation. In each case, the report provides recommendations for clinicians, based on the current state of the art, and suggests a clinical research agenda. The initiation and development of appropriate clinical studies requires a focus on devising suitable outcome measures, including a disease activity index, an optimal damage index, and a specific quality of life index.
Palavras-chave
Antiphospholipid syndrome, direct oral anticoagulants, biologics, complement inhibition, anti-&#946, 2-glycoprotein I peptides, potential new players
URI
https://observatorio.fm.usp.br/handle/OPI/41009
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Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/17
Artigos e Materiais de Revistas Científicas - ODS/03