The Mechanoreceptor's Role in Plantar Skin Changes in Individuals with Diabetes Mellitus

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art_ZIPPENFENNIG_The_Mechanoreceptors_Role_in_Plantar_Skin_Changes_in_2021.PDF (1.81 MB)
Citações na Scopus
11
Tipo de produção
article
Data de publicação
2021
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
MDPI
Autores
ZIPPENFENNIG, Claudio
DRECHSEL, Tina J.
MILANI, Thomas L.
Citação
JOURNAL OF CLINICAL MEDICINE, v.10, n.12, article ID 2537, 11p, 2021
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Mechanical skin properties (MSPs) and vibration perception thresholds (VPTs) show no relationship in healthy subjects. Similar results were expected when comparing MSP and VPT in individuals with diabetes mellitus (DM) and with diabetic (peripheral-)neuropathy (DPN). A healthy control group (33 CG), 20 DM and 13 DPN participated in this cross-sectional study. DM and DPN were classified by using a fuzzy decision support system. VPTs (in mu m) were measured with a modified vibration exciter at two different frequencies (30 and 200 Hz) and locations (heel, first metatarsal head). Skin hardness (durometer readings) and thickness (ultrasound) were measured at the same locations. DPN showed the highest VPTs compared to DM and CG at both frequencies and locations. Skin was harder in DPN compared to CG (heel). No differences were observed in skin thickness. VPTs at 30 and 200 Hz correlated negatively with skin hardness for DPN and with skin thickness for DM, respectively. This means, the harder or thicker the skin, the better the perception of 30 or 200 Hz vibrations. Changes in MSP may compensate the loss of sensitivity up to a certain progression of the disease. However, the influence seems rather small when considering other parameters, such as age.
Palavras-chave
skin hardness, skin thickness, vibration perception threshold, mechanoreceptors, sensory perception, diabetic neuropathy
URI
https://observatorio.fm.usp.br/handle/OPI/41423
Referências
  1. Aaberg ML, 2008, J DIABETES COMPLICAT, V22, P83, DOI 10.1016/j.jdiacomp.2007.06.009
  2. Abouaesha F, 2001, DIABETES CARE, V24, P1270, DOI 10.2337/diacare.24.7.1270
  3. Abraira VE, 2013, NEURON, V79, P618, DOI 10.1016/j.neuron.2013.07.051
  4. Alam U, 2017, DIABETES THER, V8, P1253, DOI 10.1007/s13300-017-0295-y
  5. Chao CYL, 2011, ULTRASOUND MED BIOL, V37, P1029, DOI 10.1016/j.ultrasmedbio.2011.04.004
  6. Chatzistergos PE, 2014, J DIABETES COMPLICAT, V28, P488, DOI 10.1016/j.jdiacomp.2014.03.011
  7. Cobo R, 2021, J CLIN MED, V10, DOI 10.3390/jcm10020227
  8. Deshpande N, 2008, AM J PHYS MED REHAB, V87, P921, DOI 10.1097/PHM.0b013e31818a5556
  9. Drechsel T.J., J CLIN MED
  10. FALANGA V, 1993, J AM ACAD DERMATOL, V29, P47, DOI 10.1016/0190-9622(93)70150-R
  11. Firooz A, 2017, SKIN RES TECHNOL, V23, P13, DOI 10.1111/srt.12294
  12. Germano AMC, 2018, GAIT POSTURE, V60, P194, DOI 10.1016/j.gaitpost.2017.12.007
  13. Gibbons CH, 2010, DIABETES CARE, V33, P2629, DOI 10.2337/dc10-0763
  14. Goddard K, 2018, JMIR RES PROTOC, V7, DOI 10.2196/resprot.7438
  15. Hilz MJ, 1998, J NEUROL SCI, V159, P219, DOI 10.1016/S0022-510X(98)00177-4
  16. Holowka NB, 2019, NATURE, V571, P261, DOI 10.1038/s41586-019-1345-6
  17. KEKONI J, 1989, EXP BRAIN RES, V78, P419
  18. Khavkin J, 2011, FACIAL PLAST SURG CL, V19, P229, DOI 10.1016/j.fsc.2011.04.003
  19. Lindholm E, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0212921
  20. Mildren RL, 2016, GAIT POSTURE, V43, P87, DOI 10.1016/j.gaitpost.2015.10.027
  21. Nelander J, 2012, DIABETIC MED, V29, pe449, DOI 10.1111/dme.12024
  22. NikkelsTassoudji N, 1996, DERMATOLOGY, V192, P19, DOI 10.1159/000246307
  23. Pare M, 2007, J COMP NEUROL, V501, P543, DOI 10.1002/cne.21262
  24. Periyasamy R, 2012, P I MECH ENG H, V226, P305, DOI 10.1177/0954411911435613
  25. Perry SD, 2006, NEUROSCI LETT, V392, P62, DOI 10.1016/j.neulet.2005.08.060
  26. Piaggesi A, 1999, J DIABETES COMPLICAT, V13, P129, DOI 10.1016/S1056-8727(98)00022-1
  27. Picon AP, 2012, CLINICS, V67, P151, DOI 10.6061/clinics/2012(02)10
  28. SANDERS JE, 1995, J REHABIL RES DEV, V32, P214
  29. Schmidt D., 2019, COGENT MED, V6, P1673086, DOI [10.1080/2331205X.2019.1673086, DOI 10.1080/2331205X.2019.1673086]
  30. Schmidt D, 2020, PEERJ, V8, DOI 10.7717/peerj.8479
  31. Shetty Shibani, 2012, Oman Med J, V27, P348, DOI 10.5001/omj.2012.90
  32. Shun CT, 2004, BRAIN, V127, P1593, DOI 10.1093/brain/awh180
  33. Strzalkowski NDJ, 2015, PHYSIOL REP, V3, DOI 10.14814/phy2.12425
  34. Thomas V Jacob, 2003, Int J Low Extrem Wounds, V2, P132, DOI 10.1177/1534734603258601
  35. Watari R, 2014, J NEUROENG REHABIL, V11, DOI 10.1186/1743-0003-11-11
  36. Ziegler D., 2019, DTSCH GESUNDHEITSBER, P92
  37. Zimmerman A, 2014, SCIENCE, V346, P950, DOI 10.1126/science.1254229
  38. Zippenfennig C., J CLIN MED

Coleções
Artigos e Materiais de Revistas Científicas - FM/MFT
Artigos e Materiais de Revistas Científicas - LIM/54
Artigos e Materiais de Revistas Científicas - ODS/03