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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | OLIVEIRA, Cristina Mendes de | - |
dc.contributor.author | FREGNANI, Jose Humberto Tavares Guerreiro | - |
dc.contributor.author | CARVALHO, Jesus Paula | - |
dc.contributor.author | LONGATTO-FILHO, Adhemar | - |
dc.contributor.author | LEVI, Jose Eduardo | - |
dc.date.accessioned | 2014-01-28T22:25:22Z | - |
dc.date.available | 2014-01-28T22:25:22Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | BMC CANCER, v.13, article ID 357, 8p, 2013 | - |
dc.identifier.issn | 1471-2407 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/4153 | - |
dc.description.abstract | Background: Invasive cervical cancer is the second most common malignant tumor affecting Brazilian women. Knowledge on Human Papillomavirus (HPV) genotypes in invasive cervical cancer cases is crucial to guide the introduction and further evaluate the impact of new preventive strategies based on HPV. We aimed to provide updated comprehensive data about the HPV types' distribution in patients with invasive cervical cancer. Methods: Fresh tumor tissue samples of histologically confirmed invasive cervical cancer were collected from 175 women attending two cancer reference hospitals from Sao Paulo State: ICESP and Hospital de Cancer de Barretos. HPV detection and genotyping were performed by the Linear Array HPV Genotyping Test (Roche Molecular Diagnostics, Pleasanton, USA). Results: 170 out of 172 valid samples (99%) were HPV DNA positive. The most frequent types were HPV16 (77.6%), HPV18 (12.3%), HPV31 (8.8%), HPV33 (7.1%) and HPV35 (5.9%). Most infections (75%) were caused by individual HPV types. Women with adenocarcinoma were not younger than those with squamous cell carcinoma, as well, as women infected with HPV33 were older than those infected by other HPV types. Some differences between results obtained in the two hospitals were observed: higher overall prevalence of HPV16, absence of single infection by HPV31 and HPV45 was verified in HC-Barretos in comparison to ICESP patients. Conclusions: To our knowledge, this is one of the largest studies made with fresh tumor tissues of invasive cervical cancer cases in Brazil. This study depicted a distinct HPV genotype distribution between two centers that may reflect the local epidemiology of HPV transmission among these populations. Due to the impact of these findings on cervical cancer preventive strategies, extension of this investigation to routine screening populations is warranted. | - |
dc.language.iso | eng | - |
dc.publisher | BIOMED CENTRAL LTD | - |
dc.relation.ispartof | BMC Cancer | - |
dc.rights | openAccess | - |
dc.subject | Human Papillomavirus (HPV) | - |
dc.subject | Invasive cervical cancer (ICC) | - |
dc.subject | Brazil | - |
dc.subject.other | worldwide | - |
dc.subject.other | classification | - |
dc.subject.other | prevalence | - |
dc.subject.other | carcinomas | - |
dc.subject.other | neoplasia | - |
dc.subject.other | lesions | - |
dc.subject.other | update | - |
dc.subject.other | women | - |
dc.subject.other | dna | - |
dc.title | Human papillomavirus genotypes distribution in 175 invasive cervical cancer cases from Brazil | - |
dc.type | article | - |
dc.rights.holder | Copyright BIOMED CENTRAL LTD | - |
dc.identifier.doi | 10.1186/1471-2407-13-357 | - |
dc.identifier.pmid | 23883423 | - |
dc.subject.wos | Oncology | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.author.external | OLIVEIRA, Cristina Mendes de:Univ Sao Paulo, Inst Trop Med, Virol Lab, Sao Paulo, Brazil | - |
hcfmusp.author.external | FREGNANI, Jose Humberto Tavares Guerreiro:Hosp Canc Barretos, Fundacao Pio 12, Nucleo Apoio Ao Pesquisador, Sao Paulo, Brazil | - |
hcfmusp.description.articlenumber | 357 | - |
hcfmusp.description.volume | 2013 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | 2-s2.0-84880369131 | - |
hcfmusp.origem.id | WOS:000322330600001 | - |
hcfmusp.publisher.city | LONDON | - |
hcfmusp.publisher.country | ENGLAND | - |
hcfmusp.relation.reference | Bernard HU, 2010, VIROLOGY, V401, P70, DOI 10.1016/j.virol.2010.02.002 | - |
hcfmusp.relation.reference | Bosch FX, 2002, J CLIN PATHOL, V55, P244 | - |
hcfmusp.relation.reference | BOSCH FX, 1995, J NATL CANCER I, V87, P796, DOI 10.1093/jnci/87.11.796 | - |
hcfmusp.relation.reference | Bouvard V, 2009, LANCET ONCOL, V10, P321 | - |
hcfmusp.relation.reference | Campbell CMP, 2012, INT J GYNECOL OBSTET, V116, P47, DOI 10.1016/j.ijgo.2011.08.008 | - |
hcfmusp.relation.reference | Castellsague X, 2006, J NATL CANCER I, V98, P303, DOI 10.1093/jnci/djj067 | - |
hcfmusp.relation.reference | Dalstein V, 2009, J VIROL METHODS, V156, P77, DOI 10.1016/j.jviromet.2008.11.002 | - |
hcfmusp.relation.reference | de Sanjose S, 2010, LANCET ONCOL, V11, P1048, DOI 10.1016/S1470-2045(10)70230-8 | - |
hcfmusp.relation.reference | de Villiers EM, 2004, VIROLOGY, V324, P17, DOI 10.1016/j.virol.2004.03.033 | - |
hcfmusp.relation.reference | ELUFNETO J, 1994, BRIT J CANCER, V69, P114, DOI 10.1038/bjc.1994.18 | - |
hcfmusp.relation.reference | Ferlay J, 2010, GLOBOCAN 2008 V2 0 C | - |
hcfmusp.relation.reference | Fernandes José V, 2010, BMC Res Notes, V3, P96, DOI 10.1186/1756-0500-3-96 | - |
hcfmusp.relation.reference | FIGO, 2009, GYNECOL ONCOL, V115, P325 | - |
hcfmusp.relation.reference | Greer C E, 1991, PCR Methods Appl, V1, P46 | - |
hcfmusp.relation.reference | INCA, 2011, EST 2012 INC CANC NO | - |
hcfmusp.relation.reference | Kasamatsu E, 2012, J MED VIROL, V84, P1628, DOI 10.1002/jmv.23373 | - |
hcfmusp.relation.reference | Levi JE, 1998, INT J CANCER, V76, P779, DOI 10.1002/(SICI)1097-0215(19980610)76:6<779::AID-IJC1>3.0.CO;2-V | - |
hcfmusp.relation.reference | Li N, 2011, INT J CANCER, V128, P927, DOI 10.1002/ijc.25396 | - |
hcfmusp.relation.reference | Lorenzato F, 2000, INT J GYNECOL CANCER, V10, P143, DOI 10.1046/j.1525-1438.2000.00007.x | - |
hcfmusp.relation.reference | Munoz N, 2003, NEW ENGL J MED, V348, P518, DOI 10.1056/NEJMoa021641 | - |
hcfmusp.relation.reference | Noronha V, 1999, Rev Soc Bras Med Trop, V32, P235, DOI 10.1590/S0037-86821999000300003 | - |
hcfmusp.relation.reference | Oliveira CM, 2012, GYNECOL ONCOL, V2, P18 | - |
hcfmusp.relation.reference | Rabelo-Santos SH, 2003, MEM I OSWALDO CRUZ, V98, P181, DOI 10.1590/S0074-02762003000200003 | - |
hcfmusp.relation.reference | Schiffman M, 2003, J NATL CANC I MONOGR, V31, P14 | - |
hcfmusp.relation.reference | Schiller JT, 2008, VACCINE, V26, pK53, DOI 10.1016/j.vaccine.2008.06.002 | - |
hcfmusp.relation.reference | Smith JS, 2007, INT J CANCER, V121, P621, DOI 10.1002/ijc.22527 | - |
hcfmusp.relation.reference | Vinokurova S, 2008, CANCER RES, V68, P307, DOI 10.1158/0008-5472.CAN-07-2754 | - |
hcfmusp.relation.reference | Walboomers JMM, 1999, J PATHOL, V189, P12, DOI 10.1002/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F | - |
dc.description.index | MEDLINE | - |
hcfmusp.citation.scopus | 27 | - |
hcfmusp.scopus.lastupdate | 2024-03-29 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MOG Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - HC/InCor Artigos e Materiais de Revistas Científicas - LIM/14 Artigos e Materiais de Revistas Científicas - LIM/52 Artigos e Materiais de Revistas Científicas - LIM/58 Artigos e Materiais de Revistas Científicas - ODS/03 |
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