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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | MENDONCA, Leonardo Oliveira | - |
dc.contributor.author | TERRERI, Maria Teresa | - |
dc.contributor.author | OSAKU, Fabiane Mitie | - |
dc.contributor.author | BARROS, Samar Freschi | - |
dc.contributor.author | KOHLER, Karen Francine | - |
dc.contributor.author | PRADO, Alex Isidoro | - |
dc.contributor.author | BARROS, Myrthes Toledo | - |
dc.contributor.author | KALIL, Jorge | - |
dc.contributor.author | CASTRO, Fabio Fernandes Morato | - |
dc.date.accessioned | 2021-10-20T13:55:47Z | - |
dc.date.available | 2021-10-20T13:55:47Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | PEDIATRIC RHEUMATOLOGY, v.19, n.1, article ID 126, 6p, 2021 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/42039 | - |
dc.description.abstract | Background Mutations along PSTPIP1 gene are associated to two specific conditions, PAPA syndrome and PAMI syndrome, both autoinflammatory disorders associated to disturbances in cytoskeleton formation. Immunological aspects of PAMI syndrome has not yet been reported neither the clinical impact on therapeutical decisions. Methods Clinical data of patients records were retrospectively accessed. Genomic DNA were extracted and sequenced following standard procedures. Peripheral lymphocytes were quantified in T, B e FOXP3 phenotypes. Results We describe two related patients with PAMI syndrome harboring the usual E250K mutation. Anti-IL1 therapy could partially control the disease in the index patient. A broad spectrum of immunological effects as well as an aberrant expression of FOXP3 could be observed. Conclusions Here we report two related brazilian patients with PAMI syndromes harboring the E250K mutation in PSTPIP1, their immunological aspects and the therapeutical response to canakinumab. | eng |
dc.language.iso | eng | - |
dc.publisher | BMC | eng |
dc.relation.ispartof | Pediatric Rheumatology | - |
dc.rights | openAccess | eng |
dc.title | Immunological repertoire linked to PSTPIP1-associated myeloid-related inflammatory (PAMI) syndrome | eng |
dc.type | article | eng |
dc.rights.holder | Copyright BMC | eng |
dc.identifier.doi | 10.1186/s12969-021-00617-y | - |
dc.identifier.pmid | 34399798 | - |
dc.subject.wos | Pediatrics | eng |
dc.subject.wos | Rheumatology | eng |
dc.type.category | original article | eng |
dc.type.version | publishedVersion | eng |
hcfmusp.author.external | TERRERI, Maria Teresa:Univ Fed Sao Paulo, Sch Med, Pediat Rheumatol Dept, Sao Paulo, Brazil | - |
hcfmusp.author.external | OSAKU, Fabiane Mitie:Hosp Infantil Joana de Gusmao, Pediat Rheumatol, Florianopolis, SC, Brazil | - |
hcfmusp.description.articlenumber | 126 | - |
hcfmusp.description.issue | 1 | - |
hcfmusp.description.volume | 19 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | WOS:000686696100003 | - |
hcfmusp.origem.id | 2-s2.0-85112572208 | - |
hcfmusp.publisher.city | LONDON | eng |
hcfmusp.publisher.country | ENGLAND | eng |
hcfmusp.relation.reference | Boursier G, 2021, J INVEST DERMATOL, V141, P1141, DOI 10.1016/j.jid.2020.08.028 | eng |
hcfmusp.relation.reference | Cortesio CL, 2010, ARTHRITIS RHEUM-US, V62, P2556, DOI 10.1002/art.27521 | eng |
hcfmusp.relation.reference | de Jesus AA, 2013, CLIN IMMUNOL, V147, P155, DOI 10.1016/j.clim.2013.03.016 | eng |
hcfmusp.relation.reference | Janssen WJM, 2018, J ALLERGY CLIN IMMUN, V142, P1947, DOI 10.1016/j.jaci.2018.01.030 | eng |
hcfmusp.relation.reference | Lu L, 2017, NAT REV IMMUNOL, V17, P703, DOI 10.1038/nri.2017.75 | eng |
hcfmusp.relation.reference | Mejbri M, 2019, ANN RHEUM DIS, V78, P977, DOI 10.1136/annrheumdis-2019-eular.8133 | eng |
hcfmusp.relation.reference | Park SH, 2019, J BIOL CHEM, V294, P17951, DOI 10.1074/jbc.RA119.010545 | eng |
hcfmusp.relation.reference | Shoham NG, 2003, P NATL ACAD SCI USA, V100, P13501, DOI 10.1073/pnas.2135380100 | eng |
dc.description.index | MEDLINE | eng |
dc.identifier.eissn | 1546-0096 | - |
hcfmusp.citation.scopus | 3 | - |
hcfmusp.scopus.lastupdate | 2024-04-12 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MCM Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - HC/InCor Artigos e Materiais de Revistas Científicas - LIM/19 Artigos e Materiais de Revistas Científicas - LIM/60 |
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File | Description | Size | Format | |
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art_MENDONCA_Immunological_repertoire_linked_to_PSTPIP1associated_myeloidrelated_inflammatory_PAMI_2021.PDF | publishedVersion (English) | 788.42 kB | Adobe PDF | View/Open |
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