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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | MORAES-VIEIRA, Pedro Manoel M. | - |
dc.contributor.author | TAKENAKA, Maisa C. S. | - |
dc.contributor.author | SILVA, Hernandez M. | - |
dc.contributor.author | MONTEIRO, Sandra Maria | - |
dc.contributor.author | AGENA, Fabiana | - |
dc.contributor.author | LEMOS, Francine | - |
dc.contributor.author | SAITOVITCH, David | - |
dc.contributor.author | KALIL, Jorge | - |
dc.contributor.author | COELHO, Veronica | - |
dc.date.accessioned | 2013-07-30T14:41:43Z | - |
dc.date.available | 2013-07-30T14:41:43Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | CLINICAL IMMUNOLOGY, v.142, n.2, p.117-126, 2012 | - |
dc.identifier.issn | 1521-6616 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/423 | - |
dc.description.abstract | Some organ-transplanted patients achieve a state of ""operational tolerance"" (01) in which graft function is maintained after the complete withdrawal of immunosuppressive drugs. We used a gene panel of regulatory/inflammatory molecules (FOXP3, GATA3, 100, TGFB1, TGFBR1/TBX21, TNF and IFNG) to investigate the gene expression profile in peripheral blood mononuclear cells of renal-transplanted individuals experiencing OT compared to transplanted individuals not displaying OT and healthy individuals (HI). OT subjects showed a predominant regulatory (REG) profile with higher gene expression of GATA3, FOXP3, TGFB1 and TGFB receptor 1 compared to the other groups. This predominant REG gene expression profile displayed stability over time. The significant GATA3 gene and protein expressions in OT individuals suggest that a Th2 deviation may be a relevant pathway to OT. Moreover, the capacity of the REG/INFLAMMA gene panel to discriminate OT by peripheral blood analysis indicates that this state has systemic repercussions. | - |
dc.description.sponsorship | FAPESP | - |
dc.description.sponsorship | CNPq | - |
dc.language.iso | eng | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.relation.ispartof | Clinical Immunology | - |
dc.rights | restrictedAccess | - |
dc.subject | Operational tolerance | - |
dc.subject | GATA-3 | - |
dc.subject | TGF-beta | - |
dc.subject.other | kidney-transplantation | - |
dc.subject.other | peripheral-blood | - |
dc.subject.other | immune tolerance | - |
dc.subject.other | target genes | - |
dc.subject.other | th2 clones | - |
dc.subject.other | t-bet | - |
dc.subject.other | recipients | - |
dc.subject.other | individuals | - |
dc.subject.other | acceptance | - |
dc.subject.other | rejection | - |
dc.title | GATA3 and a dominant regulatory gene expression profile discriminate operational tolerance in human transplantation | - |
dc.type | article | - |
dc.rights.holder | Copyright ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.identifier.doi | 10.1016/j.clim.2011.08.015 | - |
dc.identifier.pmid | 22019771 | - |
dc.subject.wos | Immunology | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.author.external | SAITOVITCH, David:Pontificia Univ Catolica Rio Grande do Sul, Sao Lucas Hosp, Div Nephrol, Porto Alegre, RS, Brazil | - |
hcfmusp.description.beginpage | 117 | - |
hcfmusp.description.endpage | 126 | - |
hcfmusp.description.issue | 2 | - |
hcfmusp.description.volume | 142 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | WOS:000300388200006 | - |
hcfmusp.origem.id | 2-s2.0-84856536708 | - |
hcfmusp.publisher.city | SAN DIEGO | - |
hcfmusp.publisher.country | USA | - |
hcfmusp.relation.reference | Berlanda M, 2008, TRANSPL P, V40, P1847, DOI 10.1016/j.transproceed.2008.05.013 | - |
hcfmusp.relation.reference | Blokzijl A, 2002, CURR BIOL, V12, P35, DOI 10.1016/S0960-9822(01)00623-6 | - |
hcfmusp.relation.reference | Braud C, 2008, J CELL BIOCHEM, V103, P1681, DOI 10.1002/jcb.21574 | - |
hcfmusp.relation.reference | Brouard S, 2005, AM J TRANSPLANT, V5, P330, DOI 10.1111/j.1600-6143.2004.00700.x | - |
hcfmusp.relation.reference | Brouard S, 2007, P NATL ACAD SCI USA, V104, P15448, DOI 10.1073/pnas.0705834104 | - |
hcfmusp.relation.reference | COCKCROFT DW, 1976, NEPHRON, V16, P31, DOI 10.1159/000180580 | - |
hcfmusp.relation.reference | Cornell LD, 2008, ANNU REV PATHOL-MECH, V3, P189, DOI 10.1146/annurev.pathol.3.121806.151508 | - |
hcfmusp.relation.reference | Golshayan D, 2008, DRUGS, V68, P2113, DOI 10.2165/00003495-200868150-00004 | - |
hcfmusp.relation.reference | Jenner RG, 2009, P NATL ACAD SCI USA, V106, P17876, DOI 10.1073/pnas.0909357106 | - |
hcfmusp.relation.reference | Kist-van Holthe JE, 2002, KIDNEY INT, V62, P627 | - |
hcfmusp.relation.reference | Koch MA, 2009, NAT IMMUNOL, V10, P595, DOI 10.1038/ni.1731 | - |
hcfmusp.relation.reference | Lee WC, 2000, TRANSPLANT P, V32, P2076, DOI 10.1016/S0041-1345(00)01575-X | - |
hcfmusp.relation.reference | Louis S, 2006, TRANSPLANTATION, V81, P398, DOI 10.1097/01.tp.0000203166.44968.86 | - |
hcfmusp.relation.reference | Moraes-Vieira PMM, 2010, HUM IMMUNOL, V71, P442, DOI 10.1016/j.humimm.2010.01.022 | - |
hcfmusp.relation.reference | PEARCE EJ, 1991, J EXP MED, V173, P159, DOI 10.1084/jem.173.1.159 | - |
hcfmusp.relation.reference | Pfaffl MW, 2001, NUCLEIC ACIDS RES, V29, DOI 10.1093/nar/29.9.e45 | - |
hcfmusp.relation.reference | Pons JA, 2008, TRANSPLANTATION, V86, P1370, DOI 10.1097/TP.0b013e318188d3e6 | - |
hcfmusp.relation.reference | Sivozhelezov V, 2008, J CELL BIOCHEM, V103, P1693, DOI 10.1002/jcb.21557 | - |
hcfmusp.relation.reference | Solez K, 2008, AM J TRANSPLANT, V8, P753, DOI 10.1111/j.1600-6143.2008.02159.x | - |
hcfmusp.relation.reference | Tone Y, 2008, NAT IMMUNOL, V9, P194, DOI 10.1038/ni1549 | - |
hcfmusp.relation.reference | VanBuskirk AM, 2000, J CLIN INVEST, V106, P145, DOI 10.1172/JCI9171 | - |
hcfmusp.relation.reference | Vieira PM, 2009, CLIN IMMUNOL, V131, pS165, DOI 10.1016/j.clim.2009.03.489 | - |
hcfmusp.relation.reference | Waaga AM, 2001, J CLIN INVEST, V107, P909, DOI 10.1172/JCI11427 | - |
hcfmusp.relation.reference | Zheng JA, 2011, EUR J IMMUNOL, V41, P128, DOI 10.1002/eji.201040724 | - |
dc.description.index | MEDLINE | - |
hcfmusp.remissive.sponsorship | CNPq | - |
hcfmusp.remissive.sponsorship | FAPESP | - |
hcfmusp.lim.ref | 2012 | - |
hcfmusp.citation.scopus | 30 | - |
hcfmusp.scopus.lastupdate | 2024-04-12 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MCM Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - HC/InCor Artigos e Materiais de Revistas Científicas - LIM/19 |
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