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https://observatorio.fm.usp.br/handle/OPI/43675
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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | MEDINA, Jesus E. | - |
dc.contributor.author | RANDOLPH, Gregory W. | - |
dc.contributor.author | ANGELOS, Peter | - |
dc.contributor.author | ZAFEREO, Mark E. | - |
dc.contributor.author | TUFANO, Ralph P. | - |
dc.contributor.author | KOWALSKI, Luiz P. | - |
dc.contributor.author | MONTENEGRO, Fabio L. M. | - |
dc.contributor.author | OWEN, Randall P. | - |
dc.contributor.author | KHAFIF, Avi | - |
dc.contributor.author | SUAREZ, Carlos | - |
dc.contributor.author | SHAHA, Ashok R. | - |
dc.contributor.author | RODRIGO, Juan P. | - |
dc.contributor.author | KREMPL, Greg A. | - |
dc.contributor.author | RINALDO, Alessandra | - |
dc.contributor.author | SILVER, Carl E. | - |
dc.contributor.author | FERLITO, Alfio | - |
dc.date.accessioned | 2021-12-16T14:15:08Z | - |
dc.date.available | 2021-12-16T14:15:08Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, v.43, n.12, p.3996-4009, 2021 | - |
dc.identifier.issn | 1043-3074 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/43675 | - |
dc.description.abstract | Genetic, symptomatic, and biochemical heterogeneity of patients with primary hyperparathyroidism (PHPT) has become apparent in recent years. An in-depth, evidence-based review of the phenotypes of PHPT was conducted. This review was intended to provide the resulting information to surgeons who operate on patients with hyperparathyroidism. This review revealed that the once relatively clear distinction between familial and sporadic PHPT has become more challenging by the finding of various germline mutations in patients with seemingly sporadic PHPT. On the one hand, the genetic and clinical characteristics of some syndromes in which PHPT is an important component are now better understood. On the other hand, knowledge is emerging about novel syndromes, such as the rare multiple endocrine neoplasia type IV (MEN4), in which PHPT occurs frequently. It also revealed that, currently, the classical array of symptoms of PHPT is seen rarely upon initial presentation for evaluation. More common are nonspecific, nonclassical symptoms and signs of PHPT. In areas of the world where serum calcium levels are checked routinely, most patients today are ""asymptomatic"" and they are diagnosed after an incidental finding of hypercalcemia; however, some of them have subclinical involvement of bones and kidneys, which is demonstrated on radiographs, ultrasound, and modern imaging techniques. Last, the review points out that there are three distinct biochemical phenotypes of PHPT. The classical phenotype in which calcium and parathyroid hormone levels are both elevated, and other disease presentations in which the serum levels of calcium or intact parathyroid hormone are normal. Today several, distinct phenotypes of the disease can be identified, and they have implications in the diagnostic evaluation and treatment of patients, as well as possible screening of relatives. | eng |
dc.language.iso | eng | - |
dc.publisher | WILEY | eng |
dc.relation.ispartof | Head and Neck-Journal for the Sciences and Specialties of the Head and Neck | - |
dc.rights | restrictedAccess | eng |
dc.subject | hyperparathyroidism | eng |
dc.subject | phenotypes | eng |
dc.subject.other | vitamin-d deficiency | eng |
dc.subject.other | normocalcemic primary hyperparathyroidism | eng |
dc.subject.other | trabecular bone score | eng |
dc.subject.other | jaw tumor syndrome | eng |
dc.subject.other | parathyroid-hormone | eng |
dc.subject.other | ionized calcium | eng |
dc.subject.other | surgery | eng |
dc.subject.other | guidelines | eng |
dc.subject.other | management | eng |
dc.subject.other | mutations | eng |
dc.title | Primary hyperparathyroidism: A disease of diverse genetic, symptomatic, and biochemical phenotypes | eng |
dc.type | article | eng |
dc.rights.holder | Copyright WILEY | eng |
dc.identifier.doi | 10.1002/hed.26861 | - |
dc.identifier.pmid | 34541734 | - |
dc.subject.wos | Otorhinolaryngology | eng |
dc.subject.wos | Surgery | eng |
dc.type.category | review | eng |
dc.type.version | publishedVersion | eng |
hcfmusp.author.external | MEDINA, Jesus E.:Univ Oklahoma, Coll Med, Dept Otolaryngol & Head & Neck Surg, Oklahoma City, OK 73190 USA | - |
hcfmusp.author.external | RANDOLPH, Gregory W.:Massachusetts Eye & Ear Infirm, Dept Otolaryngol, Div Thyroid & Parathyroid Endocrine Surg, 243 Charles St, Boston, MA 02114 USA | - |
hcfmusp.author.external | ANGELOS, Peter:Univ Chicago, Dept Surg, Chicago, IL USA; Univ Chicago, MacLean Ctr Clin Med Eth, Chicago, IL USA | - |
hcfmusp.author.external | ZAFEREO, Mark E.:Univ Texas MD Anderson Canc Ctr, Head & Neck Endocrine Surg, Houston, TX 77030 USA | - |
hcfmusp.author.external | TUFANO, Ralph P.:Johns Hopkins Baltimore, Dept Otolaryngol Head & Neck Surg, Div Head & Neck Endocrine Surg, Baltimore, MD USA | - |
hcfmusp.author.external | OWEN, Randall P.:Mt Sinai Sch Med, Dept Surg, Div Surg Oncol, New York, NY USA | - |
hcfmusp.author.external | KHAFIF, Avi:Assuta Med Ctr, ARM Ctr Adv Otolaryngol Head & Neck Surg, Head & Neck Surg & Oncol Unit, Tel Aviv, Israel | - |
hcfmusp.author.external | SUAREZ, Carlos:CIBERONC, Inst Invest Sanitaria Principado Asturias, IUOPA, Oviedo, Spain | - |
hcfmusp.author.external | SHAHA, Ashok R.:Mem Sloan Kettering Canc Ctr, Head & Neck Serv, New York, NY USA | - |
hcfmusp.author.external | RODRIGO, Juan P.:Univ Oviedo, Hosp Univ Cent Asturias, Oviedo, Spain | - |
hcfmusp.author.external | KREMPL, Greg A.:Univ Oklahoma, Coll Med, Dept Otolaryngol & Head & Neck Surg, Oklahoma City, OK 73190 USA | - |
hcfmusp.author.external | RINALDO, Alessandra:Univ Udine, Sch Med, Udine, Italy | - |
hcfmusp.author.external | SILVER, Carl E.:Univ Arizona, Coll Med, Dept Surg, Phoenix, AZ USA | - |
hcfmusp.author.external | FERLITO, Alfio:Int Head & Neck Sci Grp, Padua, Italy | - |
hcfmusp.description.beginpage | 3996 | - |
hcfmusp.description.endpage | 4009 | - |
hcfmusp.description.issue | 12 | - |
hcfmusp.description.volume | 43 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | WOS:000697913500001 | - |
hcfmusp.origem.id | 2-s2.0-85115099232 | - |
hcfmusp.publisher.city | HOBOKEN | eng |
hcfmusp.publisher.country | USA | eng |
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dc.description.index | MEDLINE | eng |
dc.identifier.eissn | 1097-0347 | - |
hcfmusp.citation.scopus | 7 | - |
hcfmusp.scopus.lastupdate | 2024-03-29 | - |
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