Please use this identifier to cite or link to this item:
https://observatorio.fm.usp.br/handle/OPI/43759
Title: | Associacao Brasileira de Hematologia, Hemoterapia e Terapia Celular Consensus on genetically modified cells. VII. Present and future of technologies for production of CAR cell therapies |
Authors: | RAMOS, Rodrigo Nalio; PICANCO-CASTRO, Virginia; OLIVEIRA, Theo Gremen M.; MENDRONE, Alfredo; SANTIS, Gil Cunha De; BONAMINO, Martin Hernan; ROCHA, Vanderson |
Citation: | HEMATOLOGY TRANSFUSION AND CELL THERAPY, v.43, suppl.2, p.S46-S53, 2021 |
Abstract: | Chimeric Antigen Receptor T (CAR-T) cells are certainly an important therapy for patients with relapsed and/or refractory hematologic malignancies. Currently, there are five CAR-T cell products approved by the FDA but several research groups and/or biopharmaceutical companies are encouraged to develop new products based on CAR cells using T or other cell types. Production of CAR cells requires intensive work from the basic, pre-clinical to translational levels, aiming to overcome technical difficulties and failure in the production. At least five key common steps are needed for the manipulation of T-lymphocytes (or other cells), such as: cell type selection, activation, gene delivery, cell expansion and final product formulation. However, reproducible manufacturing of high-quality clinical-grade CAR cell products is still required to apply this technology to a greater number of patients. This chapter will discuss the present and future development of new CAR designs that are safer and more effective to improve this therapy, achieving more selective killing of malignant cells and less toxicity to be applied in the clinical setting. (C) 2021 Published by Elsevier Espana, S.L.U. on behalf of Associacao Brasileira de Hematologia, Hemoterapia e Terapia Celular. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MCM Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/31 Artigos e Materiais de Revistas Científicas - ODS/09 |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
art_RAMOS_Associacao_Brasileira_de_Hematologia_Hemoterapia_e_Terapia_Celular_2021.PDF | publishedVersion (English) | 678.11 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.