https://observatorio.fm.usp.br/handle/OPI/43887
Title: | Obesity and its implications on cerebral circulation and intracranial compliance in severe COVID-19 |
Authors: | BRASIL, Sergio; RENCK, Alessandra Covallero; TACCONE, Fabio Silvio; SOLLA, Davi Jorge Fontoura; TOMAZINI, Bruno Martins; WAYHS, Samia Yasin; FONSECA, Sergio; BASSI, Estevao; LUCENA, Bruno; NOGUEIRA, Ricardo De Carvalho; PAIVA, Wellingson; TEIXEIRA, Manoel Jacobsen; COSTA, Elaine Maria Frade; MALBOUISSON, Luiz Marcelo Sa |
Citation: | OBESITY SCIENCE & PRACTICE, v.7, n.6, p.751-759, 2021 |
Abstract: | Objective: Multiple factors have been identified as causes of intracranial compliance impairment (ICCI) among patients with obesity. On the other hand, obesity has been linked with worst outcomes in COVID-19. Thus, the hypothesis of severe acute respiratory syndrome (SARS) conducing to cerebral hemodynamic disorders (CHD) able to worsen ICCI and play an additional role on prognosis determination for COVID-19 among obese patients becomes suitable. Methods: 50 cases of SARS by COVID-19 were evaluated, for the presence of ICCI and cerebrovascular circulatory disturbances in correspondence with whether unfavorable outcomes (death or impossibility for mechanical ventilation weaning [MVW]) within 7 days after evaluation. The objective was to observe whether obese patients (BMI >= 30) disclosed worse outcomes and tests results compared with lean subjects with same clinical background. Results: 23 (46%) patients among 50 had obesity. ICCI was verified in 18 (78%) obese, whereas in 13 (48%) of 27 non-obese (p = 0,029). CHD were not significantly different between groups, despite being high prevalent in both. 69% unfavorable outcomes were observed among obese and 44% for lean subjects (p = 0,075). Conclusion: In the present study, intracranial compliance impairment was significantly more observed among obese subjects and may have contributed for SARS COVID-19 worsen prognosis. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - COVID-19 Artigos e Materiais de Revistas Científicas - FM/MNE Artigos e Materiais de Revistas Científicas - HC/ICESP Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/08 Artigos e Materiais de Revistas Científicas - LIM/42 Artigos e Materiais de Revistas Científicas - LIM/45 Artigos e Materiais de Revistas Científicas - LIM/62 Artigos e Materiais de Revistas Científicas - ODS/03 |
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art_BRASIL_Obesity_and_its_implications_on_cerebral_circulation_and_2021.PDF | publishedVersion (English) | 339.78 kB | Adobe PDF | View/Open |
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