Multi-scale semi-supervised clustering of brain images: Deriving disease subtypes
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Citações na Scopus
23
Tipo de produção
article
Data de publicação
2022
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER
Autores
WEN, Junhao
VAROL, Erdem
SOTIRAS, Aristeidis
YANG, Zhijian
CHAND, Ganesh B.
ERUS, Guray
SHOU, Haochang
ABDULKADIR, Ahmed
HWANG, Gyujoon
DWYER, Dominic B.
Citação
MEDICAL IMAGE ANALYSIS, v.75, article ID 102304, 18p, 2022
Resumo
Disease heterogeneity is a significant obstacle to understanding pathological processes and delivering pre-cision diagnostics and treatment. Clustering methods have gained popularity for stratifying patients into subpopulations (i.e., subtypes) of brain diseases using imaging data. However, unsupervised clustering approaches are often confounded by anatomical and functional variations not related to a disease or pathology of interest. Semi-supervised clustering techniques have been proposed to overcome this and, therefore, capture disease-specific patterns more effectively. An additional limitation of both unsuper-vised and semi-supervised conventional machine learning methods is that they typically model, learn and infer from data using a basis of feature sets pre-defined at a fixed anatomical or functional scale (e.g., atlas-based regions of interest). Herein we propose a novel method, ""Multi-scAle heteroGeneity analysIs and Clustering"" (MAGIC), to depict the multi-scale presentation of disease heterogeneity, which builds on a previously proposed semi-supervised clustering method, HYDRA. It derives multi-scale and clinically interpretable feature representations and exploits a double-cyclic optimization procedure to effectively drive identification of inter-scale-consistent disease subtypes. More importantly, to understand the conditions under which the clustering model can estimate true heterogeneity related to diseases, we conducted extensive and systematic semi-simulated experiments to evaluate the proposed method on a sizeable healthy control sample from the UK Biobank ( N = 4403). We then applied MAGIC to imaging data from Alzheimer's disease (ADNI, N = 1728) and schizophrenia (PHENOM, N = 1166) patients to demonstrate its potential and challenges in dissecting the neuroanatomical heterogeneity of common brain diseases. Taken together, we aim to provide guidance regarding when such analyses can succeed or should be taken with caution. The code of the proposed method is publicly available at https://github.com/anbai106/MAGIC .
Palavras-chave
Semi-supervised, Clustering, Multi-scale, Heterogeneity, Semi-simulated
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