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Title: Endothelium Activation during Severe Yellow Fever Triggers an Intense Cytokine-Mediated Inflammatory Response in the Liver Parenchyma
Authors: OLIMPIO, Fabio AlvesFALCAO, Luiz Fabio MagnoCARVALHO, Marcos Luiz GaiaLOPES, Jeferson da CostaMENDES, Caio Cesar HenriquesFILHO, Arnaldo Jorge MartinsSILVA, Carlos Augusto Moreira daMIRANDA, Vanessa do Socorro CabralSANTOS, Lais Carneiro dosVILACOERT, Fellipe Souza da SilvaCRUZ, Ana Cecilia RibeiroGALUCIO, Vanessa Costa AlvesAZEVEDO, Raimunda do Socorro da SilvaMARTINS, Livia CaricioDUARTE, Maria Irma SeixasSOUSA, Jorge Rodrigues deVASCONCELOS, Pedro Fernando da CostaQUARESMA, Juarez Antonio Simoes
Citation: PATHOGENS, v.11, n.1, article ID 101, 7p, 2022
Abstract: Yellow fever (YF) is a pansystemic disease caused by the yellow fever virus (YFV), the prototype species of the family Flaviviridae and genus Flavivirus, and has a highly complex host-pathogen relationship, in which endothelial dysfunction reflects viral disease tropism. In this study, the in situ endothelial response was evaluated. Liver tissue samples were collected from 21 YFV-positive patients who died due to the disease and five flavivirus-negative controls who died of other causes and whose hepatic parenchyma architecture was preserved. Immunohistochemical analysis of tissues in the hepatic parenchyma of YF cases showed significantly higher expression of E-selectin, P-selectin, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and very late antigen-4 in YFV-positive cases than in flavivirus-negative controls. These results indicate that endothelium activation aggravates the inflammatory response by inducing the expression of adhesion molecules that contribute to the rolling, recruitment, migration, and construction of the inflammatory process in the hepatic parenchyma in fatal YF cases.
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Artigos e Materiais de Revistas Científicas - FM/MPT
Departamento de Patologia - FM/MPT

Artigos e Materiais de Revistas Científicas - LIM/06
LIM/06 - Laboratório de Imunopatologia da Esquistossomose e outras Parasitoses

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