Endothelium Activation during Severe Yellow Fever Triggers an Intense Cytokine-Mediated Inflammatory Response in the Liver Parenchyma
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Citações na Scopus
4
Tipo de produção
article
Data de publicação
2022
Título da Revista
ISSN da Revista
Título do Volume
Editora
MDPI
Autores
OLIMPIO, Fabio Alves
CARVALHO, Marcos Luiz Gaia
LOPES, Jeferson da Costa
MENDES, Caio Cesar Henriques
FILHO, Arnaldo Jorge Martins
SILVA, Carlos Augusto Moreira da
MIRANDA, Vanessa do Socorro Cabral
SANTOS, Lais Carneiro dos
VILACOERT, Fellipe Souza da Silva
Citação
PATHOGENS, v.11, n.1, article ID 101, 7p, 2022
Resumo
Yellow fever (YF) is a pansystemic disease caused by the yellow fever virus (YFV), the prototype species of the family Flaviviridae and genus Flavivirus, and has a highly complex host-pathogen relationship, in which endothelial dysfunction reflects viral disease tropism. In this study, the in situ endothelial response was evaluated. Liver tissue samples were collected from 21 YFV-positive patients who died due to the disease and five flavivirus-negative controls who died of other causes and whose hepatic parenchyma architecture was preserved. Immunohistochemical analysis of tissues in the hepatic parenchyma of YF cases showed significantly higher expression of E-selectin, P-selectin, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and very late antigen-4 in YFV-positive cases than in flavivirus-negative controls. These results indicate that endothelium activation aggravates the inflammatory response by inducing the expression of adhesion molecules that contribute to the rolling, recruitment, migration, and construction of the inflammatory process in the hepatic parenchyma in fatal YF cases.
Palavras-chave
yellow fever, liver, vascular endothelium, adhesion molecule
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