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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorLOURENCO, Luiz Otavio-
dc.contributor.authorRIBEIRO, Alessandra Mussi-
dc.contributor.authorLOPES, Fernanda Degobbi Tenorio Quirino Dos Santos-
dc.contributor.authorTIBERIO, Iolanda de Fatima Lopes Calvo-
dc.contributor.authorTAVARES-DE-LIMA, Wothan-
dc.contributor.authorPRADO, Carla Maximo-
dc.identifier.citationCLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY, v.62, n.1, Special Issue, p.240-263, 2022-
dc.description.abstractAsthma is a respiratory allergic disease presenting a high prevalence worldwide, and it is responsible for several complications throughout life, including death. Fortunately, asthma is no longer recognized as a unique manifestation but as a very heterogenic manifestation. Its phenotypes and endotypes are known, respectively, as pathologic and molecular features that might not be directly associated with each other. The increasing number of studies covering this issue has brought significant insights and knowledge that are constantly expanding. In this review, we intended to summarize this new information obtained from clinical studies, which not only allowed for the creation of patient clusters by means of personalized medicine and a deeper molecular evaluation, but also created a connection with data obtained from experimental models, especially murine models. We gathered information regarding sensitization and trigger and emphasizing the most relevant phenotypes and endotypes, such as Th2-(high) asthma and Th2-(low) asthma, which included smoking and obesity-related asthma and mixed and paucigranulocytic asthma, not only in physiopathology and the clinic but also in how these phenotypes can be determined with relative similarity using murine models. We also further investigated how clinical studies have been treating patients using newly developed drugs focusing on specific biomarkers that are more relevant according to the patient's clinical manifestation of the disease.eng
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e TecnologicoConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) [303035/2018-8]-
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel SuperiorCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) [001]-
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao PauloFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2018/06088-0]-
dc.publisherHUMANA PRESS INCeng
dc.relation.ispartofClinical Reviews in Allergy & Immunology-
dc.subjectAnimal modelseng
dc.subjectClinical dataeng
dc.subject.otherinnate lymphoid-cellseng
dc.subject.otherallergic airway inflammationeng
dc.subject.othermurine modelseng
dc.subject.othermouse modeleng
dc.subject.otherneutrophilic inflammationeng
dc.subject.otherpersistent asthmaeng
dc.titleDifferent Phenotypes in Asthma: Clinical Findings and Experimental Animal Modelseng
dc.rights.holderCopyright HUMANA PRESS INCeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng, Luiz Otavio:Univ Fed Sao Paulo, Dept Biosci, Campus Baixada Santista, Santos, SP, Brazil-, Alessandra Mussi:Univ Fed Sao Paulo, Dept Biosci, Campus Baixada Santista, Santos, SP, Brazil-, Wothan:Univ Sao Paulo, Inst Biomed Sci, Dept Pharmacol, Sao Paulo, SP, Brazil-
hcfmusp.description.issueSpecial Issue-
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