Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/45850
Full metadata record
DC FieldValueLanguage
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorLOURENCO, Luiz Otavio-
dc.contributor.authorRIBEIRO, Alessandra Mussi-
dc.contributor.authorLOPES, Fernanda Degobbi Tenorio Quirino Dos Santos-
dc.contributor.authorTIBERIO, Iolanda de Fatima Lopes Calvo-
dc.contributor.authorTAVARES-DE-LIMA, Wothan-
dc.contributor.authorPRADO, Carla Maximo-
dc.date.accessioned2022-04-19T12:56:19Z-
dc.date.available2022-04-19T12:56:19Z-
dc.date.issued2022-
dc.identifier.citationCLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY, v.62, n.1, Special Issue, p.240-263, 2022-
dc.identifier.issn1080-0549-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/45850-
dc.description.abstractAsthma is a respiratory allergic disease presenting a high prevalence worldwide, and it is responsible for several complications throughout life, including death. Fortunately, asthma is no longer recognized as a unique manifestation but as a very heterogenic manifestation. Its phenotypes and endotypes are known, respectively, as pathologic and molecular features that might not be directly associated with each other. The increasing number of studies covering this issue has brought significant insights and knowledge that are constantly expanding. In this review, we intended to summarize this new information obtained from clinical studies, which not only allowed for the creation of patient clusters by means of personalized medicine and a deeper molecular evaluation, but also created a connection with data obtained from experimental models, especially murine models. We gathered information regarding sensitization and trigger and emphasizing the most relevant phenotypes and endotypes, such as Th2-(high) asthma and Th2-(low) asthma, which included smoking and obesity-related asthma and mixed and paucigranulocytic asthma, not only in physiopathology and the clinic but also in how these phenotypes can be determined with relative similarity using murine models. We also further investigated how clinical studies have been treating patients using newly developed drugs focusing on specific biomarkers that are more relevant according to the patient's clinical manifestation of the disease.eng
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e TecnologicoConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) [303035/2018-8]-
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel SuperiorCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) [001]-
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao PauloFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2018/06088-0]-
dc.language.isoeng-
dc.publisherHUMANA PRESS INCeng
dc.relation.ispartofClinical Reviews in Allergy & Immunology-
dc.rightsrestrictedAccesseng
dc.subjectAsthmaeng
dc.subjectAnimal modelseng
dc.subjectClinical dataeng
dc.subjectPhenotypeseng
dc.subject.otherinnate lymphoid-cellseng
dc.subject.otherallergic airway inflammationeng
dc.subject.otherror-gamma-teng
dc.subject.othermurine modelseng
dc.subject.othermouse modeleng
dc.subject.otherneutrophilic inflammationeng
dc.subject.othermonoclonal-antibodyeng
dc.subject.otherpersistent asthmaeng
dc.subject.othercluster-analysiseng
dc.subject.othermiceeng
dc.titleDifferent Phenotypes in Asthma: Clinical Findings and Experimental Animal Modelseng
dc.typearticleeng
dc.rights.holderCopyright HUMANA PRESS INCeng
dc.identifier.doi10.1007/s12016-021-08894-x-
dc.identifier.pmid34542807-
dc.subject.wosAllergyeng
dc.subject.wosImmunologyeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
hcfmusp.author.externalLOURENCO, Luiz Otavio:Univ Fed Sao Paulo, Dept Biosci, Campus Baixada Santista, Santos, SP, Brazil-
hcfmusp.author.externalRIBEIRO, Alessandra Mussi:Univ Fed Sao Paulo, Dept Biosci, Campus Baixada Santista, Santos, SP, Brazil-
hcfmusp.author.externalTAVARES-DE-LIMA, Wothan:Univ Sao Paulo, Inst Biomed Sci, Dept Pharmacol, Sao Paulo, SP, Brazil-
hcfmusp.description.beginpage240-
hcfmusp.description.endpage263-
hcfmusp.description.issue1-
hcfmusp.description.issueSpecial Issue-
hcfmusp.description.volume62-
hcfmusp.origemWOS-
hcfmusp.origem.idWOS:000698085800002-
hcfmusp.origem.id2-s2.0-85115187814-
hcfmusp.publisher.cityTOTOWAeng
hcfmusp.publisher.countryUSAeng
hcfmusp.relation.referenceAcciani TH, 2013, CLIN EXP ALLERGY, V43, P1406, DOI 10.1111/cea.12200eng
hcfmusp.relation.referenceAchakulwisut P, 2019, LANCET PLANET HEALTH, V3, pE166, DOI 10.1016/S2542-5196(19)30046-4eng
hcfmusp.relation.referenceAgache I, 2020, ALLERGY, V75, P1023, DOI 10.1111/all.14221eng
hcfmusp.relation.referenceAgache I, 2019, J CLIN INVEST, V129, P1493, DOI 10.1172/JCI124611eng
hcfmusp.relation.referenceAkdis M, 2016, J ALLERGY CLIN IMMUN, V138, P984, DOI 10.1016/j.jaci.2016.06.033eng
hcfmusp.relation.referenceAl-Alwan A, 2014, AM J RESP CRIT CARE, V189, P1494, DOI 10.1164/rccm.201401-0178OCeng
hcfmusp.relation.referenceAl-Harbi NO, 2019, EUR J PHARMACOL, V855, P276, DOI 10.1016/j.ejphar.2019.05.026eng
hcfmusp.relation.referenceAlberg T, 2009, J TOXICOL ENV HEAL A, V72, P1, DOI 10.1080/15287390802414471eng
hcfmusp.relation.referenceAlbers FC, 2019, RESP RES, V20, DOI 10.1186/s12931-019-1134-7eng
hcfmusp.relation.referenceAmrani Y, 2004, CURR OPIN PHARMACOL, V4, P230, DOI 10.1016/j.coph.2004.02.004eng
hcfmusp.relation.referenceAnderson GP, 2008, LANCET, V372, P1107, DOI 10.1016/S0140-6736(08)61452-Xeng
hcfmusp.relation.referenceHaldar P, 2008, AM J RESP CRIT CARE, V178, P218, DOI 10.1164/rccm.200711-1754OCeng
hcfmusp.relation.referenceHaldar P, 2007, J ALLERGY CLIN IMMUN, V119, P1043, DOI 10.1016/j.jaci.2007.02.042eng
hcfmusp.relation.referenceHarb H, 2020, CLIN EXP ALLERGY, V50, P5, DOI 10.1111/cea.13491eng
hcfmusp.relation.referenceHaspeslagh E, 2017, METHODS MOL BIOL, V1559, P121, DOI 10.1007/978-1-4939-6786-5_10eng
hcfmusp.relation.referenceHastie AT, 2013, J ALLERGY CLIN IMMUN, V132, P72, DOI 10.1016/j.jaci.2013.03.044eng
hcfmusp.relation.referenceHe ZG, 2018, CELL DEATH DIS, V9, DOI 10.1038/s41419-018-1223-4eng
hcfmusp.relation.referenceHekking PPW, 2014, J ALLER CL IMM-PRACT, V2, P671, DOI 10.1016/j.jaip.2014.09.007eng
hcfmusp.relation.referenceHenderson WR, 2002, AM J RESP CRIT CARE, V165, P108, DOI 10.1164/ajrccm.165.1.2105051eng
hcfmusp.relation.referenceHew M, 2020, J ALLER CL IMM-PRACT, V8, P2222, DOI 10.1016/j.jaip.2020.02.036eng
hcfmusp.relation.referenceKomi DEA, 2019, CLIN REV ALLERG IMMU, V56, P234, DOI 10.1007/s12016-018-8720-1eng
hcfmusp.relation.referenceWilhelm C, 2011, NAT IMMUNOL, V12, P1071, DOI 10.1038/ni.2133eng
hcfmusp.relation.referenceHirota JA, 2009, PULM PHARMACOL THER, V22, P370, DOI 10.1016/j.pupt.2008.12.004eng
hcfmusp.relation.referenceHong JY, 2014, RESP RES, V15, DOI 10.1186/1465-9921-15-63eng
hcfmusp.relation.referenceHoyler T, 2012, IMMUNITY, V37, P634, DOI 10.1016/j.immuni.2012.06.020eng
hcfmusp.relation.referenceHsu CL, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0226701eng
hcfmusp.relation.referenceHumbles AA, 2004, SCIENCE, V305, P1776, DOI 10.1126/science.1100283eng
hcfmusp.relation.referenceHumeniuk P, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18071491eng
hcfmusp.relation.referenceIbrahim H, 2019, RESP RES, V20, DOI 10.1186/s12931-019-1251-3eng
hcfmusp.relation.referenceIto K, 2008, AM J RESP CELL MOL, V39, P543, DOI 10.1165/rcmb.2008-0028OCeng
hcfmusp.relation.referenceKorn T, 2009, ANNU REV IMMUNOL, V27, P485, DOI 10.1146/annurev.immunol.021908.132710eng
hcfmusp.relation.referenceAno S, 2013, J IMMUNOL, V190, P1056, DOI 10.4049/jimmunol.1202386eng
hcfmusp.relation.referenceWilson RH, 2009, AM J RESP CRIT CARE, V180, P720, DOI 10.1164/rccm.200904-0573OCeng
hcfmusp.relation.referenceKubo M, 2017, IMMUNOL REV, V278, P162, DOI 10.1111/imr.12557eng
hcfmusp.relation.referenceKumar RK, 2012, FRONT PHYSIOL, V3, DOI 10.3389/fphys.2012.00312eng
hcfmusp.relation.referenceKUNKEL SL, 1991, EXP LUNG RES, V17, P17, DOI 10.3109/01902149109063278eng
hcfmusp.relation.referenceKuruvilla ME, 2019, CLIN REV ALLERG IMMU, V56, P219, DOI 10.1007/s12016-018-8712-1eng
hcfmusp.relation.referenceLambrecht BN, 2019, IMMUNITY, V50, P975, DOI 10.1016/j.immuni.2019.03.018eng
hcfmusp.relation.referenceLambrecht BN, 2015, NAT IMMUNOL, V16, P45, DOI 10.1038/ni.3049eng
hcfmusp.relation.referenceLee JJ, 2004, SCIENCE, V305, P1773, DOI 10.1126/science.1099472eng
hcfmusp.relation.referenceLeitch VD, 2009, IMMUNOL CELL BIOL, V87, P131, DOI 10.1038/icb.2008.72eng
hcfmusp.relation.referenceLiang L, 2018, KOREAN J INTERN MED, V33, P1210, DOI 10.3904/kjim.2017.207eng
hcfmusp.relation.referenceLiang SC, 2007, J IMMUNOL, V179, P7791, DOI 10.4049/jimmunol.179.11.7791eng
hcfmusp.relation.referenceWolterink RGJK, 2012, EUR J IMMUNOL, V42, P1106, DOI 10.1002/eji.201142018eng
hcfmusp.relation.reference[Anonymous], 2019, N Engl J Med, V380, P2082, DOI 10.1056/NEJMx180026eng
hcfmusp.relation.referenceLiu WM, 2017, J ALLERGY CLIN IMMUN, V139, P1548, DOI 10.1016/j.jaci.2016.08.032eng
hcfmusp.relation.referenceLombardi C, 2017, WORLD ALLERGY ORGAN, V10, DOI 10.1186/s40413-016-0138-8eng
hcfmusp.relation.referenceLombardi V, 2010, INT ARCH ALLERGY IMM, V151, P179, DOI 10.1159/000242355eng
hcfmusp.relation.referenceLotvall J, 2011, J ALLERGY CLIN IMMUN, V127, P355, DOI 10.1016/j.jaci.2010.11.037eng
hcfmusp.relation.referenceMaddur MS, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms5092eng
hcfmusp.relation.referenceMadore AM, 2010, J ASTHMA ALLERGY, V3, P107, DOI 10.2147/JAA.S8970eng
hcfmusp.relation.referenceMaltby S, 2020, BMJ OPEN, V10, DOI 10.1136/bmjopen-2019-032877eng
hcfmusp.relation.referenceMatsuse H, 2013, RESPIRATION, V85, P429, DOI 10.1159/000345861eng
hcfmusp.relation.referenceMcBrien CN, 2017, FRONT MED-LAUSANNE, V4, DOI 10.3389/fmed.2017.00093eng
hcfmusp.relation.referenceWong EHC, 2014, LANCET RESP MED, V2, P657, DOI 10.1016/S2213-2600(14)70107-9eng
hcfmusp.relation.referenceMcKinley L, 2008, J IMMUNOL, V181, P4089, DOI 10.4049/jimmunol.181.6.4089eng
hcfmusp.relation.referenceApter AJ, 2019, J ALLERGY CLIN IMMUN, V143, P1336, DOI 10.1016/j.jaci.2018.12.1005eng
hcfmusp.relation.referenceMohanan S, 2014, EXP BIOL MED, V239, P1531, DOI 10.1177/1535370214525302eng
hcfmusp.relation.referenceMoore WC, 2010, AM J RESP CRIT CARE, V181, P315, DOI 10.1164/rccm.200906-0896OCeng
hcfmusp.relation.referenceMurdoch JR, 2010, MUTAT RES-FUND MOL M, V690, P24, DOI 10.1016/j.mrfmmm.2009.09.005eng
hcfmusp.relation.referenceNetwork GA, 2018, GLOB ASTHM REPeng
hcfmusp.relation.referenceNials AT, 2008, DIS MODEL MECH, V1, P213, DOI 10.1242/dmm.000323eng
hcfmusp.relation.referenceNissen G, 2018, CLIN EXP ALLERGY, V48, P1483, DOI 10.1111/cea.13236eng
hcfmusp.relation.referenceNtontsi P, 2017, ALLERGY, V72, P1761, DOI 10.1111/all.13184eng
hcfmusp.relation.referenceOchkur SI, 2007, J IMMUNOL, V178, P7879, DOI 10.4049/jimmunol.178.12.7879eng
hcfmusp.relation.referenceWypych TP, 2018, J ALLERGY CLIN IMMUN, V141, P1395, DOI 10.1016/j.jaci.2017.09.001eng
hcfmusp.relation.referenceOrtega HG, 2014, NEW ENGL J MED, V371, P1198, DOI 10.1056/NEJMoa1403290eng
hcfmusp.relation.referenceOzdemir C, 2018, EXPERT REV RESP MED, V12, P733, DOI 10.1080/17476348.2018.1505507eng
hcfmusp.relation.referenceAsai-Tajiri Y, 2014, RESP RES, V15, DOI 10.1186/s12931-014-0132-zeng
hcfmusp.relation.referencePanettieri RA, 2018, LANCET RESP MED, V6, P511, DOI 10.1016/S2213-2600(18)30184-Xeng
hcfmusp.relation.referencePanettieri RA, 2016, IMMUNOL ALLERGY CLIN, V36, P569, DOI 10.1016/j.iac.2016.03.007eng
hcfmusp.relation.referencePapi A, 2018, LANCET, V391, P783, DOI 10.1016/S0140-6736(17)33311-1eng
hcfmusp.relation.referencePelaia G, 2015, MEDIAT INFLAMM, V2015, DOI 10.1155/2015/879783eng
hcfmusp.relation.referencePeters MC, 2019, AM J RESP CRIT CARE, V199, P465, DOI 10.1164/rccm.201807-1291OCeng
hcfmusp.relation.referencePeters U, 2018, J ALLERGY CLIN IMMUN, V141, P1169, DOI 10.1016/j.jaci.2018.02.004eng
hcfmusp.relation.referencePeters-Golden M, 2006, EUR RESPIR J, V27, P495, DOI 10.1183/09031936.06.00077205eng
hcfmusp.relation.referenceXu XC, 2020, J IMMUNOL RES, V2020, DOI 10.1155/2020/8254909eng
hcfmusp.relation.referencePlatts-Mills TAE, 2016, J ALLERGY CLIN IMMUN, V137, P1662, DOI 10.1016/j.jaci.2016.04.010eng
hcfmusp.relation.referencePolosa R, 2013, EUR RESPIR J, V41, P716, DOI 10.1183/09031936.00073312eng
hcfmusp.relation.referencePoulsen LK, 2007, ANN MED, V39, P440, DOI 10.1080/07853890701449354eng
hcfmusp.relation.referenceAthari SS, 2019, SIGNAL TRANSDUCT TAR, V4, DOI 10.1038/s41392-019-0079-0eng
hcfmusp.relation.referencePrado CM, 2011, EXP LUNG RES, V37, P259, DOI 10.3109/01902148.2010.538289eng
hcfmusp.relation.referenceRay A, 2017, TRENDS IMMUNOL, V38, P942, DOI 10.1016/j.it.2017.07.003eng
hcfmusp.relation.referenceRay A, 2015, AM J PHYSIOL-LUNG C, V308, pL130, DOI 10.1152/ajplung.00070.2014eng
hcfmusp.relation.referenceReynolds G, 2015, FRONT IMMUNOL, V6, DOI 10.3389/fimmu.2015.00330eng
hcfmusp.relation.referenceROBINSON DS, 1992, NEW ENGL J MED, V326, P298, DOI 10.1056/NEJM199201303260504eng
hcfmusp.relation.referenceRosenberg HF, 2018, J LEUKOCYTE BIOL, V104, P41, DOI 10.1002/JLB.3MR1117-436Reng
hcfmusp.relation.referenceXue LZ, 2014, J ALLERGY CLIN IMMUN, V133, P1184, DOI 10.1016/j.jaci.2013.10.056eng
hcfmusp.relation.referenceSagar S, 2015, EUR J PHARMACOL, V759, P272, DOI 10.1016/j.ejphar.2015.03.037eng
hcfmusp.relation.referenceSalter BM, 2017, CHEST, V152, P410, DOI 10.1016/j.chest.2017.01.021eng
hcfmusp.relation.referenceSantana FPR, 2019, MEDIAT INFLAMM, V2019, DOI 10.1155/2019/1356356eng
hcfmusp.relation.referenceSerra MF, 2018, J IMMUNOL, V201, P851, DOI 10.4049/jimmunol.1700933eng
hcfmusp.relation.referenceAun MV, 2017, J ASTHMA ALLERGY, V10, P293, DOI 10.2147/JAA.S121092eng
hcfmusp.relation.referenceShinagawa K, 2003, AM J RESP CRIT CARE, V168, P959, DOI 10.1164/rccm.200210-1188OCeng
hcfmusp.relation.referenceShore SA, 2007, J APPL PHYSIOL, V102, P516, DOI 10.1152/japplphysiol.00847.2006eng
hcfmusp.relation.referenceSiroux V, 2011, EUR RESPIR J, V38, P310, DOI 10.1183/09031936.00120810eng
hcfmusp.relation.referenceSkloot GS, 2016, CURR OPIN PULM MED, V22, P3, DOI 10.1097/MCP.0000000000000225eng
hcfmusp.relation.referenceSoutham DS, 2005, J ALLERGY CLIN IMMUN, V115, P95, DOI 10.1016/j.jaci.2004.09.022eng
hcfmusp.relation.referenceYang M, 2009, J IMMUNOL, V182, P5107, DOI 10.4049/jimmunol.0803468eng
hcfmusp.relation.referenceSpears M, 2006, CLIN EXP ALLERGY, V36, P1494, DOI 10.1111/j.1365-2222.2006.02604.xeng
hcfmusp.relation.referenceTamiya T, 2013, J IMMUNOL, V191, P2360, DOI 10.4049/jimmunol.1301276eng
hcfmusp.relation.referenceTanaka H, 2004, AM J RESP CELL MOL, V31, P62, DOI 10.1165/rcmb.2003-0305OCeng
hcfmusp.relation.referenceNguyen TH, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0163392eng
hcfmusp.relation.referenceThiriou D, 2017, INT IMMUNOPHARMACOL, V48, P43, DOI 10.1016/j.intimp.2017.04.027eng
hcfmusp.relation.referenceBan GY, 2017, CLIN EXP ALLERGY, V47, P37, DOI 10.1111/cea.12797eng
hcfmusp.relation.referenceTliba O, 2019, J ALLERGY CLIN IMMUN, V143, P1287, DOI 10.1016/j.jaci.2018.06.008eng
hcfmusp.relation.referenceToledo AC, 2013, BRIT J PHARMACOL, V168, P1736, DOI 10.1111/bph.12062eng
hcfmusp.relation.referenceTung HY, 2018, SEMIN RESP CRIT CARE, V39, P64, DOI 10.1055/s-0037-1607981eng
hcfmusp.relation.referencevan der Ploeg EK, 2020, J INNATE IMMUN, V12, P47, DOI 10.1159/000496212eng
hcfmusp.relation.referenceYang N, 2019, INT IMMUNOPHARMACOL, V72, P422, DOI 10.1016/j.intimp.2019.04.044eng
hcfmusp.relation.referenceVivier E, 2018, CELL, V174, P1054, DOI 10.1016/j.cell.2018.07.017eng
hcfmusp.relation.referenceWalker JA, 2018, NAT REV IMMUNOL, V18, P121, DOI 10.1038/nri.2017.118eng
hcfmusp.relation.referenceWalker ML, 2014, FRONT IMMUNOL, V5, P1, DOI 10.3389/fimmu.2014.00447eng
hcfmusp.relation.referenceWang W, 2018, J IMMUNOL, V201, P2221, DOI 10.4049/jimmunol.1800709eng
hcfmusp.relation.referenceWenzel S, 2013, NEW ENGL J MED, V368, P2455, DOI 10.1056/NEJMoa1304048eng
hcfmusp.relation.referenceWenzel SE, 2021, AM J RESP CRIT CARE, V203, P809, DOI 10.1164/rccm.202009-3631CIeng
hcfmusp.relation.referenceBarnes PJ, 2018, NAT REV IMMUNOL, V18, P454, DOI 10.1038/s41577-018-0006-6eng
hcfmusp.relation.referenceWenzel SE, 2012, NAT MED, V18, P716, DOI 10.1038/nm.2678eng
hcfmusp.relation.referenceBarnes PJ, 2010, PHARMACEUTICALS, V3, P514, DOI 10.3390/ph3030514eng
hcfmusp.relation.referenceJonckheere AC, 2019, CURR OPIN ALLERGY CL, V19, P53, DOI 10.1097/ACI.0000000000000497eng
hcfmusp.relation.referenceYang YS, 2008, TOX RESEARCH, V24, P253, DOI 10.5487/TR.2008.24.4.253eng
hcfmusp.relation.referenceYasuda Y, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9051178eng
hcfmusp.relation.referenceYoussef M, 2020, PHARM RES-DORDR, V37, DOI 10.1007/s11095-019-2743-zeng
hcfmusp.relation.referenceYu QL, 2018, EXP THER MED, V15, P2492, DOI 10.3892/etm.2018.5721eng
hcfmusp.relation.referenceZhou L, 2008, NATURE, V453, P236, DOI 10.1038/nature06878eng
hcfmusp.relation.referenceZhu LL, 2019, INT IMMUNOPHARMACOL, V67, P396, DOI 10.1016/j.intimp.2018.12.030eng
hcfmusp.relation.referenceZhu LD, 2018, WORLD ALLERGY ORGAN, V11, DOI 10.1186/s40413-018-0208-1eng
hcfmusp.relation.referenceZosky GR, 2007, CLIN EXP ALLERGY, V37, P973, DOI 10.1111/j.1365-2222.2007.02740.xeng
hcfmusp.relation.referenceBarrett NA, 2009, J IMMUNOL, V182, P1119, DOI 10.4049/jimmunol.182.2.1119eng
hcfmusp.relation.referenceBartlett NW, 2008, NAT MED, V14, P199, DOI 10.1038/nm1713eng
hcfmusp.relation.referenceKarrasch S, 2017, THORAX, V72, P109, DOI 10.1136/thoraxjnl-2016-208704eng
hcfmusp.relation.referenceBates JHT, 2009, AM J PHYSIOL-LUNG C, V297, pL401, DOI 10.1152/ajplung.00027.2009eng
hcfmusp.relation.referenceBeavitt SJE, 2005, J IMMUNOL, V175, P1867, DOI 10.4049/jimmunol.175.3.1867eng
hcfmusp.relation.referenceBecker KL, 2015, CLIN EXP ALLERGY, V45, P423, DOI 10.1111/cea.12354eng
hcfmusp.relation.referenceBelvisi MG, 2018, RESP RES, V19, DOI 10.1186/s12931-018-0799-7eng
hcfmusp.relation.referenceBettelli E, 2006, NATURE, V441, P235, DOI 10.1038/nature04753eng
hcfmusp.relation.referenceBhakta NR, 2011, IMMUNOL REV, V242, P220, DOI 10.1111/j.1600-065X.2011.01032.xeng
hcfmusp.relation.referenceBonser LR, 2017, J CLIN MED, V6, DOI 10.3390/jcm6120112eng
hcfmusp.relation.referenceBranchett WJ, 2020, J ALLERGY CLIN IMMUN, V145, P666, DOI 10.1016/j.jaci.2019.08.006eng
hcfmusp.relation.referenceBrandt EB, 2020, CLIN EXP ALLERGY, V50, P121, DOI 10.1111/cea.13512eng
hcfmusp.relation.referenceBreiteneder H, 2020, ALLERGY, V75, P3039, DOI 10.1111/all.14582eng
hcfmusp.relation.referenceKim DI, 2019, BMC PULM MED, V19, DOI 10.1186/s12890-019-1001-9eng
hcfmusp.relation.referenceBrown JM, 2008, CLIN EXP ALLERGY, V38, P4, DOI 10.1111/j.1365-2222.2007.02886.xeng
hcfmusp.relation.referenceBRUSSELLE GG, 1994, CLIN EXP ALLERGY, V24, P73, DOI 10.1111/j.1365-2222.1994.tb00920.xeng
hcfmusp.relation.referenceBusse WW, 2013, AM J RESP CRIT CARE, V188, P1294, DOI 10.1164/rccm.201212-2318OCeng
hcfmusp.relation.referenceCamargo LD, 2018, FRONT IMMUNOL, V8, DOI 10.3389/fimmu.2017.01835eng
hcfmusp.relation.referenceCaminati M, 2018, WORLD ALLERGY ORGAN, V11, DOI 10.1186/s40413-018-0192-5eng
hcfmusp.relation.referenceCanning BJ, 2008, PULM PHARMACOL THER, V21, P702, DOI 10.1016/j.pupt.2008.01.004eng
hcfmusp.relation.referenceCanonica GW, 2018, CURR OPIN ALLERGY CL, V18, P51, DOI 10.1097/ACI.0000000000000416eng
hcfmusp.relation.referenceCayrol C, 2018, IMMUNOL REV, V281, P154, DOI 10.1111/imr.12619eng
hcfmusp.relation.referenceChang Yoon-Seok, 2005, Korean Journal of Internal Medicine, V20, P152eng
hcfmusp.relation.referenceChauhan PS, 2018, PHYTOMEDICINE, V51, P29, DOI 10.1016/j.phymed.2018.06.022eng
hcfmusp.relation.referenceKimura A, 2010, EUR J IMMUNOL, V40, P1830, DOI 10.1002/eji.201040391eng
hcfmusp.relation.referenceChen BL, 2018, CLIN EXP ALLERGY, V48, P1494, DOI 10.1111/cea.13258eng
hcfmusp.relation.referenceChen RC, 2017, AM J RESP CRIT CARE, V196, P700, DOI 10.1164/rccm.201612-2427OCeng
hcfmusp.relation.referenceCherrier DE, 2018, IMMUNITY, V48, P1091, DOI 10.1016/j.immuni.2018.05.010eng
hcfmusp.relation.referenceCho JY, 2004, J CLIN INVEST, V113, P551, DOI 10.1172/JCI200419133eng
hcfmusp.relation.referenceChoi IW, 2005, J ALLERGY CLIN IMMUN, V116, P537, DOI 10.1016/j.jaci.2005.05.034eng
hcfmusp.relation.referenceColgan JD, 2010, CURR OPIN ALLERGY CL, V10, P42, DOI 10.1097/ACI.0b013e328334f642eng
hcfmusp.relation.referenceCorren J, 2011, NEW ENGL J MED, V365, P1088, DOI 10.1056/NEJMoa1106469eng
hcfmusp.relation.referenceDe Vooght V, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0012581eng
hcfmusp.relation.referencede Vries M P, 2005, Prim Care Respir J, V14, P210, DOI 10.1016/j.pcrj.2005.04.005eng
hcfmusp.relation.referenceDeckers J, 2013, TRENDS IMMUNOL, V34, P540, DOI 10.1016/j.it.2013.08.004eng
hcfmusp.relation.referenceKinyanjui Elizabeth D, 2014, RESP RES, V15, DOI [10.1186/s12931-014-0090-5, DOI 10.1186/S12931-014-0090-5]eng
hcfmusp.relation.referenceDemarche S, 2016, BMC PULM MED, V16, DOI 10.1186/s12890-016-0208-2eng
hcfmusp.relation.referenceDhami S, 2017, ALLERGY, V72, P1825, DOI 10.1111/all.13208eng
hcfmusp.relation.referenceRodrigues APD, 2019, HISTOL HISTOPATHOL, V34, P537, DOI 10.14670/HH-18-059eng
hcfmusp.relation.referenceDIAZSANCHEZ D, 1994, J CLIN INVEST, V94, P1417, DOI 10.1172/JCI117478eng
hcfmusp.relation.referenceDing FX, 2018, MED SCI MONITOR, V24, P3220, DOI 10.12659/MSM.905202eng
hcfmusp.relation.referenceDixon AE, 2011, J ALLERGY CLIN IMMUN, V128, P508, DOI 10.1016/j.jaci.2011.06.009eng
hcfmusp.relation.referenceDomingo C, 2018, RESP RES, V19, DOI 10.1186/s12931-018-0893-xeng
hcfmusp.relation.referencedos Santos TM, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.01183eng
hcfmusp.relation.referenceDuechs MJ, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0091223eng
hcfmusp.relation.referenceDuffey H, 2019, IMMUNOL ALLERGY CLIN, V39, P561, DOI 10.1016/j.iac.2019.07.009eng
hcfmusp.relation.referenceKippelen P, 2018, IMMUNOL ALLERGY CLIN, V38, P165, DOI 10.1016/j.iac.2018.01.008eng
hcfmusp.relation.referenceEssilfie AT, 2012, THORAX, V67, P588, DOI 10.1136/thoraxjnl-2011-200160eng
hcfmusp.relation.referenceFahy JV, 2015, NAT REV IMMUNOL, V15, P57, DOI 10.1038/nri3786eng
hcfmusp.relation.referenceFAHY JV, 1995, AM J RESP CRIT CARE, V152, P53, DOI 10.1164/ajrccm.152.1.7599862eng
hcfmusp.relation.referenceFahy JV, 1997, AM J RESP CRIT CARE, V155, P1828, DOI 10.1164/ajrccm.155.6.9196082eng
hcfmusp.relation.referenceFinotto S, 2002, SCIENCE, V295, P336, DOI 10.1126/science.1065544eng
hcfmusp.relation.referenceFoster PS, 2017, IMMUNOL REV, V278, P20, DOI 10.1111/imr.12549eng
hcfmusp.relation.referenceFroidure A, 2016, EUR RESPIR J, V47, P304, DOI 10.1183/13993003.01824-2014eng
hcfmusp.relation.referenceFujimoto M, 2008, ARTHRITIS RHEUM-US, V58, P3710, DOI 10.1002/art.24126eng
hcfmusp.relation.referenceGao H, 2017, J IMMUNOL RES, V2017, DOI 10.1155/2017/3743048eng
hcfmusp.relation.referenceGao W, 2020, BIOMARK MED, V14, P211, DOI 10.2217/bmm-2019-0487eng
hcfmusp.relation.referenceKoch S, 2017, SEMIN IMMUNOPATHOL, V39, P55, DOI 10.1007/s00281-016-0601-1eng
hcfmusp.relation.referenceGarcia G, 2013, CHEST, V144, P411, DOI 10.1378/chest.12-1961eng
hcfmusp.relation.referenceGazi L, 2005, PROSTAG OTH LIPID M, V75, P153, DOI 10.1016/j.prostaglandins.2004.11.003eng
hcfmusp.relation.referenceGlobal Initiative for Asthma, 2019, GLOB STRAT ASTHM MANeng
hcfmusp.relation.referenceGon Y, 2018, ALLERGOL INT, V67, P12, DOI 10.1016/j.alit.2017.08.011eng
hcfmusp.relation.referenceGonzalez D, 2019, J INVEST ALLERG CLIN, V29, P84, DOI 10.18176/jiaci.0385eng
hcfmusp.relation.referenceGreen RH, 2002, THORAX, V57, P875, DOI 10.1136/thorax.57.10.875eng
hcfmusp.relation.referenceGu ZW, 2017, ONCOTARGET, V8, P22361, DOI 10.18632/oncotarget.15652eng
hcfmusp.relation.referenceGubernatorova EO, 2019, IMMUNOL LETT, V207, P73, DOI 10.1016/j.imlet.2018.11.012eng
hcfmusp.relation.referenceGuia S, 2020, TRENDS IMMUNOL, V41, P436, DOI 10.1016/j.it.2020.03.002eng
hcfmusp.relation.referenceGuida G, 2019, SEMIN IMMUNOL, V46, DOI 10.1016/j.smim.2019.101346eng
hcfmusp.relation.referenceKomi DEA, 2020, CLIN REV ALLERG IMMU, V58, P377, DOI 10.1007/s12016-020-08779-5eng
hcfmusp.relation.referenceHadebe S, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0134219eng
dc.description.indexMEDLINEeng
dc.identifier.eissn1559-0267-
hcfmusp.citation.scopus1-
hcfmusp.scopus.lastupdate2022-08-11-
Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/MCM
Departamento de Clínica Médica - FM/MCM

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/05
LIM/05 - Laboratório de Poluição Atmosférica Experimental

Artigos e Materiais de Revistas Científicas - LIM/20
LIM/20 - Laboratório de Terapêutica Experimental

Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar


Files in This Item:
File Description SizeFormat 
art_LOURENCO_Different_Phenotypes_in_Asthma_Clinical_Findings_and_Experimental_2022.PDF
  Restricted Access
publishedVersion (English)1.53 MBAdobe PDFView/Open Request a copy

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.