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Title: | Ingestion of orange juice prevents hyperglycemia and increases plasma miR-375 expression |
Authors: | QUINTANILHA, Bruna J.; CHAVES, Daniela F. S.; BRASILI, Elisa; CORREA, Telma A. F.; CAPETINI, Vinicius Cooper; FERREIRA, Frederico Moraes; CASTRO, Inar A.; HASSIMOTTO, Neuza M. A.; ROGERO, Marcelo M.; LAJOLO, Franco M. |
Citation: | CLINICAL NUTRITION ESPEN, v.47, p.240-245, 2022 |
Abstract: | Background & aims: The intake of high-fat, high-carbohydrate (HFHC) meals is associated with an increased risk of type 2 diabetes. There is evidence that the association of orange juice to a HFHC meal can modulate the expression of microRNAs (miRNAs) linked to pancreatic beta-cell function such as miR-375. We evaluated the effect of a commercial orange juice intake with HFHC meal on plasma miRNAs expression in twelve healthy subjects in a crossover design study. Methods: Subjects ingested water, orange juice, or an isocaloric beverage along with a 1037 kcal HFHC meal. Blood glucose and miRNAs were evaluated at baseline and 1, 3, and 5 h after the intake. Results: The area under the curve (AUC) for glycemia after ingestion of HFHC + orange juice did not differ from ingestion of HPHC + glucose or HFHC + water. However, the AUC was higher in HFHC meal + glucose compared to HFHC meal + water (p = 0.034). Glucose and insulin concentrations were significantly higher in HFHC meal + glucose group after 1 h, when compared with other groups and times (p < 0.001). There was an increase in plasma miR-375 expression after 3 h of ingestion of HFHC + orange juice versus water (p = 0.026), and a decrease in plasma miR-205-5p expression after HFHC meal + glucose versus water (p = 0.023). Conclusions: A single HFHC meal + orange juice modulated plasma miR-375 expression, which is a biomarker of pancreatic beta-cell function, and contributed to preventing hyperglycemia. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MPT Artigos e Materiais de Revistas Científicas - LIM/50 Artigos e Materiais de Revistas Científicas - ODS/03 |
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