Assessment of bone metabolism biomarkers in serum and saliva of cirrhotic patients

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art_TENORIO_Assessment_of_bone_metabolism_biomarkers_in_serum_and_2022.PDF (599.55 KB)
Citações na Scopus
1
Tipo de produção
article
Data de publicação
2022
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
SPRINGER HEIDELBERG
Autores
TENORIO, Jefferson Rocha
DUARTE, Nathalia Tuany
ANDRADE, Natalia Silva
BERGAMINI, Mariana Lobo
ORTEGA, Karem L.
Citação
CLINICAL ORAL INVESTIGATIONS, v.26, n.2, p.1861-1868, 2022
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Objective To assess the serum and salivary levels of biomarkers related to bone metabolism in cirrhotic patients as well as the evidence of osteoporotic changes on panoramic radiographs. Materials and methods Thirty-eight cirrhotic patients underwent anamnesis and physical examination. Specimens of blood and saliva were collected for evaluation by using Luminex (TM) xMAP technology to quantify RANKL, OPG, IL-1 beta, IL-6 and TNF-alpha. Panoramic radiographs were evaluated based on the mandibular cortical index (MCI) and the resulting data were compared to the expression of biomarkers in serum and saliva. Descriptive data analysis was performed and the Mann-Whitney's test and Spearman's correlation were used. Results Most of the sample consisted of males (68.4%) who had cirrhosis mostly resulting from alcoholism (28.9%). Median concentration values of RANKL (74.44 pg/mL), IL-1 beta (45.91 pg/mL), IL-6 (67.69 pg/mL) and TNF-alpha (5.97 pg/mL) in saliva were higher than those observed in serum. In 72.7% of the panoramic radiographs, MCI was found to be suggestive of osteoporotic changes. No statistically significant correlation was observed between salivary and serum expressions of biomarkers or between biomarkers and MCI. Conclusion RANKL, OPG, IL-1 beta, IL-6 and TNF-alpha are expressed differently in serum and saliva and the concentration of these biomarkers is not related to MCI.
Palavras-chave
Hepatic cirrhosis, Osteoporosis, Bone biomarkers, Saliva, Panoramic radiography
URI
https://observatorio.fm.usp.br/handle/OPI/46294
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Coleções
Artigos e Materiais de Revistas Científicas - LIM/52
Artigos e Materiais de Revistas Científicas - FM/MIP
Artigos e Materiais de Revistas Científicas - ODS/03