Platelet-albumin (PAL) score as a predictor of perioperative outcomes and survival in patients with hepatocellular carcinoma undergoing liver resection in a Western center

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art_MEIRA JUNIOR_Plateletalbumin_PAL_score_as_a_predictor_of_perioperative_2022.PDF (887.59 KB)
Citações na Scopus
4
Tipo de produção
article
Data de publicação
2022
DOI
Scopus
Web of Science
PubMed
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ISSN da Revista
Título do Volume
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ELSEVIER SCI LTD
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Citação
SURGICAL ONCOLOGY-OXFORD, v.42, article ID 101752, 7p, 2022
Projetos de Pesquisa
Unidades Organizacionais
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Resumo
Background and objectives: Preoperative selection of patients with hepatocellular carcinoma (HCC) who will benefit from resection is highly advisable. The Platelet-Albumin (PAL) score was developed as a predictor of survival and morbidity following HCC resection. However, this has never been tested in western populations.& nbsp;Methods: The impact of PAL score on perioperative outcomes and survival was evaluated and compared to Child Pugh, Model for End-Stage Liver Disease (MELD), and albumin-bilirubin (ALBI) scores in patients who underwent HCC resection.& nbsp;Results: A total of 182 patients were included. Postoperative morbidity was higher in patients with PAL grade II III (P = 0.039), ALBI grade II-III (P = 0.028), and MELD > 10 (P = 0.042). Post-hepatectomy liver failure (PHLF) occurred in 36 patients (19.8%) and was significantly higher in the PAL II-III and ALBI score II-III subgroup (P = 0.001). The PAL II-III group was the only one associated with higher perioperative mortality (OR 3.3, P = 0.036). The PAL score was an independent prognostic factor for overall survival in multivariate analysis (P = 0.018) and was the only one with the areas under the curve in ROC analysis significantly different for morbidity, PHLF, and mortality.& nbsp;Conclusions: The PAL score predicts postoperative complications, mortality, PHLF, and survival following liver resection for HCC in western patients.
Palavras-chave
Hepatectomy, Morbidity, Mortality, Survival, Liver failure
URI
https://observatorio.fm.usp.br/handle/OPI/47124
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MGT
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/02
Artigos e Materiais de Revistas Científicas - LIM/24
Artigos e Materiais de Revistas Científicas - LIM/37
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