Please use this identifier to cite or link to this item:
https://observatorio.fm.usp.br/handle/OPI/47257
Title: | Near-Complete Remission of Glioblastoma in a Patient Treated with an Allogenic Dendritic Cell-Based Vaccine: The Role of Tumor-Specific CD4+T-Cell Cytokine Secretion Pattern in Predicting Response and Recurrence |
Authors: | PINHO, Mariana P.; LEPSKI, Guilherme A.; REHDER, Roberta; CHAUCA-TORRES, Nadia E.; EVANGELISTA, Gabriela C. M.; TEIXEIRA, Sarah F.; FLATOW, Elizabeth A.; OLIVEIRA, Jaqueline V. de; FOGOLIN, Carla S.; PERES, Nataly; AREVALO, Analia; ALVES, Venancio; BARBUTO, Jose A. M.; BERGAMI-SANTOS, Patricia C. |
Citation: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.23, n.10, article ID 5396, 10p, 2022 |
Abstract: | Immunotherapy has brought hope to the fight against glioblastoma, but its efficacy remains unclear. We present the case of CST, a 25-year-old female patient with a large right-hemisphere glioblastoma treated with a dendritic-tumor cell fusion vaccine. CST showed a near-complete tumor response, with a marked improvement in her functional status and simultaneous increases in tumor-specific CD8+ and CD4+ T cells. Two months before recurrence, the frequency of tumor-specific T cells decreased, while that of IL-17 and CD4+ T cells increased. CST passed away 15 months after enrollment. In this illustrative case, the tumor-specific CD4+ T-cell numbers and phenotype behaved as treatment efficacy biomarkers, highlighting the key role of the latter in glioblastoma immunotherapy. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MPT Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/14 Artigos e Materiais de Revistas Científicas - LIM/26 Artigos e Materiais de Revistas Científicas - LIM/31 Artigos e Materiais de Revistas Científicas - ODS/03 |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
art_PINHO_NearComplete_Remission_of_Glioblastoma_in_a_Patient_Treated_2022.PDF | publishedVersion (English) | 2.47 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.