Pancreas Transplantation in a Single Center: Risk Factors Associated With Pancreatic Allograft Thrombosis

Imagem de Miniatura
Arquivos
art_ROCHA-SANTOS_Pancreas_Transplantation_in_a_Single_Center_Risk_Factors_2022.PDF (274.56 KB)
Citações na Scopus
1
Tipo de produção
article
Data de publicação
2022
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER SCIENCE INC
Autores
Citação
TRANSPLANTATION PROCEEDINGS, v.54, n.3, p.801-805, 2022
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background. Pancreas transplantation remains a challenging procedure for small and medium-sized transplants teams, despite improvements in graft survival. Data regarding the impact of the procurement team's experience on the outcomes of pancreas transplant are lacking. The objective of this study was to evaluate risk factors that lead to pancreatic allograft thrombosis, especially the experience of the pancreas procurement team. Methods. A retrospective study of 137 patients who underwent pancreas transplantation between March 2005 and May 2017 was conducted. Donor's and recipient characteristics were evaluated as well as their relationship to pancreatic allograft thrombosis. Cases were divided according to the number of pancreas procurements previously done by the procurement surgeon: group 1 (30 to 40 retrievals) and group 2 (>= 40 retrievals). Results. Simultaneous pancreas-kidney transplants accounted for 89.8% of cases (n = 123). Surgeons from group 2 performed 62.8% (n = 86) of the procurements. The graft was removed in 19 cases (13.8%) due to thrombosis. In univariate analysis, lower experience of the retrieval team was associated with allograft loss (P =.04). In multivariate analysis, donor intensive care unit time >= 5 days (P =.03) and lower experience of the procurement team were associated with increased risk of pancreatic allograft thrombosis (P =.02), whereas recipient's age from 30 to 40 years (P =.018) or >= 40 years (P =.02) was found as a protective factor. Conclusions. Pancreatic allograft thrombosis remains an important cause of graft loss in pancreas transplantation. Recipient's age, prolonged donor intensive care unit time, and lower experience of the procurement team directly influence pancreatic allograft thrombosis.
Palavras-chave
URI
https://observatorio.fm.usp.br/handle/OPI/48232
Referências
  1. Adrogue HE, 2007, CLIN TRANSPLANT, V21, P32, DOI 10.1111/j.1399-0012.2006.00574.x
  2. Argente-Pla M, 2021, CIR ESPAN, V99, P666, DOI [10.1016/j.ciresp.2020.09.012, 10.1016/j.cireng.2021.10.001]
  3. Bennett CL, 1997, ARCH SURG-CHICAGO, V132, P41
  4. Dafoe DC, 2005, CLIN TRANSPLANT, V19, P690, DOI 10.1111/j.1399-0012.2004.00295.x
  5. Farney AC, 2012, CURR OPIN ORGAN TRAN, V17, P87, DOI 10.1097/MOT.0b013e32834ee717
  6. Fridell JA, 2014, CLIN TRANSPLANT, V28, P1313, DOI 10.1111/ctr.12459
  7. Grochowiecki T, 2014, TRANSPL P, V46, P2818, DOI 10.1016/j.transproceed.2014.08.012
  8. Gruessner AC, 2005, CLIN TRANSPLANT, V19, P433, DOI 10.1111/j.1399-0012.2005.00378.x
  9. Gruessner AC, 2010, CURR OPIN ORGAN TRAN, V15, P93, DOI 10.1097/MOT.0b013e32833552d2
  10. KELLY WD, 1967, SURGERY, V61, P827
  11. Kopp WH, 2019, TRANSPL INT, V32, P410, DOI 10.1111/tri.13384
  12. Laftavi MR, 2014, TRANSPL P, V46, P1900, DOI 10.1016/j.transproceed.2014.06.043
  13. Lindahl JP, 2013, DIABETOLOGIA, V56, P1364, DOI 10.1007/s00125-013-2888-y
  14. Lindahl JP, 2014, DIABETES RES CLIN PR, V105, P14, DOI 10.1016/j.diabres.2014.03.004
  15. Marang-van de Mheen PJ, 2011, CLIN TRANSPLANT, V25, P737, DOI 10.1111/j.1399-0012.2010.01335.x
  16. Michalak G, 2005, TRANSPL P, V37, P3555, DOI 10.1016/j.transproceed.2005.09.077
  17. Muthusamy ASR, 2010, TRANSPLANTATION, V90, P705, DOI 10.1097/TP.0b013e3181eb2ea0
  18. Nagakawa Y, 2018, J HEPATO-BIL-PAN SCI, V25, P498, DOI 10.1002/jhbp.586
  19. Parsons RF, 2014, CURR OPIN ORGAN TRAN, V19, P100, DOI 10.1097/MOT.0000000000000063
  20. Prystowsky JB, 2005, ARCH SURG-CHICAGO, V140, P495, DOI 10.1001/archsurg.140.5.495
  21. Redfield RR, 2015, CURR OPIN ORGAN TRAN, V20, P94, DOI 10.1097/MOT.0000000000000146
  22. Sansalone CV, 2005, TRANSPLANT P, V37, P2651, DOI 10.1016/j.transproceed.2005.06.103
  23. Schenker P, 2008, TRANSPL P, V40, P923, DOI 10.1016/j.transproceed.2008.03.078
  24. Sollinger HW, 2009, ANN SURG, V250, P618, DOI [10.1097/SLA.0b013e3181b76d2b, 10.1097/SLA.0b013e3181b7d2b]
  25. Stewart ZA, 2009, AM J TRANSPLANT, V9, P217, DOI 10.1111/j.1600-6143.2008.02449.x
  26. Stratta RJ, 2016, AM J TRANSPLANT, V16, P2556, DOI 10.1111/ajt.13890
  27. Stratta RJ, 2016, CURR OPIN ORGAN TRAN, V21, P386, DOI 10.1097/MOT.0000000000000319
  28. Troppmann C, 2010, CURR OPIN ORGAN TRAN, V15, P112, DOI 10.1097/MOT.0b013e3283355349
  29. Watson DI, 1996, ANN SURG, V224, P198, DOI 10.1097/00000658-199608000-00013

Coleções
Artigos e Materiais de Revistas Científicas - FM/MCG
Artigos e Materiais de Revistas Científicas - FM/MGT
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/37
Artigos e Materiais de Revistas Científicas - LIM/55