Fat mass to fat-free mass ratio and its associations with clinical characteristics in asthma

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art_RUGILA_Fat_mass_to_fatfree_mass_ratio_and_its_2022.PDF (596.73 KB)
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0
Tipo de produção
article
Data de publicação
2022
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
MOSBY-ELSEVIER
Autores
RUGILA, Diery Fernandes
OLIVEIRA, Joice Mara
MACHADO, Felipe Vilaca Cavallari
CORREIA, Natielly Soares
PUZZI, Vitoria Cavalheiro
PITTA, Fabio
FURLANETTO, Karina Couto
Citação
HEART & LUNG, v.56, p.154-160, 2022
Projetos de Pesquisa
Unidades Organizacionais
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Resumo
Background: Fat mass to fat-free mass ratio (FM/FFM) assesses the combined effect of the balance between fat mass and fat-free mass. Aims: to evaluate the associations beetween FM/FFM and clinical outcomes in asthma and to compare clinical characteristics between individuals with higher and lower FM/FFM. Methods: 128 participants with asthma underwent anthropometric, spirometry and bioelectrical impedance assessments. Physical activity in daily life (PADL) was assessed by the Actigraph for 7 days. Daily dose of inhaled medication, steps of pharmacological treatment, Asthma Control Questionnaire, Asthma Quality of Life Questionnaire and Hospital Anxiety and Depression Scale were also assessed. Participants were classified into two groups according to the 50th percentile of reference values for FM/FFM. Results: Individuals with higher FM/FFM (n=75) used higher daily doses of inhaled corticosteroids, had worse lung function and fewer steps/day when compared to those with lower FM/FFM (n=53) (P <= 0.021). Associations were found between absolute values of FM/FFM with lung function (FEV1 and FVC [liters]): R-2=0.207 and 0.364;P<0.0001), and between the categories of lower or higher FM/FFM with steps of medication treatment (Cramer's V=0.218;P=0.016) and level of PADL (Cramer's V=0.236;P=0.009). The highest FM/FFM was a determining factor of physical inactivity (OR: 3.21;95%CI:1.17-8.78) and highest steps of pharmacological treatment (OR: 8.89;95%CI:1.23-64.08). Conclusion: Higher FM/FFM is significantly associated with worse clinical characteristics in individuals with asthma, such as higher doses of inhaled corticosteroids, worse lung function and fewer steps/day. Moreover, higher FM/FFM is a determining factor of physical inactivity and the highest steps of pharmacological treatment for asthma.
Palavras-chave
Asthma, Body composition, Respiratory function tests, Drug therapy, Motor activity, ACQ Asthma Control Questionnaire, AQLQ Asthma Quality of Life Questionnaire, BMI, Body mass index, FM, Fat mass, FFM, Fat-free mass, FM/FFM, Fat mass to fat-free mass ratio, FEV1, Forced expiratory volume in the first second, FVC, Forced vital capacity, FEV1/FVC Forced expiratory volume in the first second to forced vital capacity ratio, GINA, Global Initiative for Asthma, HADS, Hospital Anxiety and Depression Scale, PADL, Physical Activity in Daily Life
URI
https://observatorio.fm.usp.br/handle/OPI/49193
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MFT
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/20
Artigos e Materiais de Revistas Científicas - ODS/03