Please use this identifier to cite or link to this item:
https://observatorio.fm.usp.br/handle/OPI/49238
Title: | Effect of MTTP-493G/T, I128T, Q95H and Q244E polymorphisms on hepatic steatosis in patients with chronic hepatitis |
Authors: | PRATA, Thamiris Vaz Gago; MANCHIERO, Caroline; DANTAS, Bianca Peixoto; NUNES, Arielle Karen da Silva; TENGAN, Fatima Mitiko; MAGRI, Mariana Cavalheiro |
Citation: | CLINICS, v.77, article ID 100094, 8p, 2022 |
Abstract: | Background: Chronic hepatitis C is characterized by a progressive deterioration of liver function and is involved in metabolic complications, such as hepatic steatosis.Objective: The aim of this study was to investigate the role of host and viral characteristics associated with-493G/ T (rs1800591), I128T (rs3816873), Q95H (rs61733139), and Q244E (rs17599091) Single Nucleotide Polymor-phisms (SNPs) in the Microsomal Triglyceride Transfer Protein (MTTP) gene on hepatic steatosis in chronic hepatitis C.Methods: SNPs were genotyped by PCR-RFLP and analyzed in combination with host and viral characteristics by multiple logistic regression in different genetic models of inheritance.Results: The authors analyzed 236 patients with chronic hepatitis C, and 53% had hepatic steatosis. The mutated allele frequencies were > 5%, and the genotypes were in Hardy-Weinberg equilibrium (p >= 0.05). It was observed that patients with HCV genotype 3 infection (OR = 2.74, 95% CI 1.24-6.06, p = 0.013), female sex (OR = 2.28, 95% CI 1.21-4.28, p = 0.011) and moderate-and high-intensity liver inflammatory activity (A2-A3) (OR = 3.61, 95% CI 1.86-7.01, p < 0.001) alone exhibited a higher risk of steatosis. The results of multiple logistic regression analysis for interaction showed that for the-493G/T SNP, when the GT/TT genotype (dominant model) and the GT genotype (codominant model) were each combined with HCV genotype 3 infection, an 11.51-fold (95% CI 2.08-63.59, p = 0.005) and a 15.69-fold (95% CI 2.46-99.85, p = 0.004) increased risk of steatosis, respectively, was observed. For the I128T SNP, when both the IT/TT genotype (dominant model) and the IT geno-type (codominant model) were combined with HCV genotype 3 infection, an 8.51-fold (95% CI 1.59-45.54, p = 0.012) and an 8.40 fold (95% CI 1.51-46.91, p = 0.015) increased risk of steatosis, respectively, was observed. Conclusion: The present study showed that the viral genotype combined with the-493G/T and I128T SNPs in the MTTP gene influences hepatic steatosis. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MIP Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - HC/InCor Artigos e Materiais de Revistas Científicas - LIM/47 Artigos e Materiais de Revistas Científicas - ODS/03 |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
art_PRATA_Effect_of_MTTP493GT_I128T_Q95H_and_Q244E_polymorphisms_2022.PDF | publishedVersion (English) | 385.42 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.