The oldest unvaccinated Covid-19 survivors in South America

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art_V_The_oldest_unvaccinated_Covid19_survivors_in_South_America_2022.PDF (1.27 MB)
Citações na Scopus
5
Tipo de produção
article
Data de publicação
2022
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
BMC
Autores
V, Mateus de Castro
SILVA, Monize V. R.
NASLAVSKY, Michel S.
SCLIAR, Marilia O.
NUNES, Kelly
PASSOS-BUENO, Maria Rita
CASTELLI, Erick C.
ADAMI, Flavia L.
Citação
IMMUNITY & AGEING, v.19, n.1, article ID 57, 9p, 2022
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background Although older adults are at a high risk of severe or critical Covid-19, there are many cases of unvaccinated centenarians who had a silent infection or recovered from mild or moderate Covid-19. We studied three Brazilian supercentenarians, older than 110 years, who survived Covid-19 in 2020 before being vaccinated. Results Despite their advanced age, humoral immune response analysis showed that these individuals displayed robust levels of IgG and neutralizing antibodies (NAbs) against SARS-CoV-2. Enrichment of plasma proteins and metabolites related to innate immune response and host defense was also observed. None presented autoantibodies (auto-Abs) to type I interferon (IFN). Furthermore, these supercentenarians do not carry rare variants in genes underlying the known inborn errors of immunity, including particular inborn errors of type I IFN. Conclusion These observations suggest that their Covid-19 resilience might be a combination of their genetic background and their innate and adaptive immunity.
Palavras-chave
Covid-19, Supercentenarians, SARS-CoV-2, Elderly
URI
https://observatorio.fm.usp.br/handle/OPI/50398
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - COVID-19
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/19
Artigos e Materiais de Revistas Científicas - LIM/60
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