Immunological imbalance in microcephalic children with congenital Zika virus syndrome

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art_SALMERON_Immunological_imbalance_in_microcephalic_children_with_congenital_Zika_2022.PDF (2.22 MB)
Citações na Scopus
2
Tipo de produção
article
Data de publicação
2022
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
SPRINGER
Autores
SALMERON, Amanda Costa Ayres
BEZERRA, Wallace Pitanga
SOUZA, Rafaela Lucia Lopes de
PEREIRA, Luanderson Cardoso
NASCIMENTO, Licia Maria do
SIMAS, Luiza Emilia Cavalcanti
ALMEIDA, Valeria Azevedo de
PALMEIRA, Pedro Henrique de Souza
BEZERRA, Christiane Medeiros
Citação
MEDICAL MICROBIOLOGY AND IMMUNOLOGY, v.211, n.5-6, p.219-235, 2022
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Microcephalic children due congenital Zika virus syndrome (CZS) present neurological symptoms already well described. However, several other alterations can also be observed. Here, we aimed to evaluate the immune system of microcephaly CZS children. We showed that these patients have enlarged thymus, spleen and cervical lymph nodes, analysed by ultrasound and compared to the reference values for healthy children. In the periphery, they have an increase in eosinophil count and morphological alterations as hypersegmented neutrophils and atypical lymphocytes, even in the absence of urinary tract infections, parasitological infections or other current symptomatic infections. Microcephalic children due CZS also have high levels of IFN-gamma, IL-2, IL-4, IL-5 and type I IFNs, compared to healthy controls. In addition, this population showed a deficient cellular immune memory as demonstrated by the low reactivity to the tuberculin skin test even though they had been vaccinated with BCG less than 2 years before the challenge with the PPD. Together, our data demonstrate for the first time that CZS can cause alterations in primary and secondary lymphoid organs and also alters the morphology and functionality of the immune system cells, which broadens the spectrum of CZS symptoms. This knowledge may assist the development of specific therapeutic and more efficient vaccination schemes for this population of patients.
Palavras-chave
Congenital Zika syndrome, Microcephaly, Immune system, Lymphoid organ, Cytokines, Immune memory
URI
https://observatorio.fm.usp.br/handle/OPI/50495
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MDT
Artigos e Materiais de Revistas Científicas - LIM/56
Artigos e Materiais de Revistas Científicas - ODS/03