Vitamin A and Beta-Carotene Concentrations in Adults with HIV/AIDS on Highly Active Antiretroviral Therapy
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Citações na Scopus
6
Tipo de produção
article
Data de publicação
2013
Título da Revista
ISSN da Revista
Título do Volume
Editora
CENTER ACADEMIC PUBL JAPAN
Autores
KAIO, Daniella Junko
RONDO, Patricia Helen Carvalho
SOUZA, Jose Maria Pacheco
FIRMINO, Aline Vale
LUZIA, Liania Alves
Citação
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, v.59, n.6, p.496-502, 2013
Resumo
Micronutrient deficiency is a common condition in HIV-infected individuals and may occur in all stages of the disease. The objective of this cross-sectional study was to compare the concentrations of vitamin A and beta-carotene, micronutrients related to immunity and oxidative stress, in 182 adults with HIV/AIDS, under different highly active antiretroviral therapy (HAART) regimens. Patients were divided into 3 groups according to their HAART regimen: combination of nucleoside analog reverse transcriptase inhibitors (NRTIs) and non-NRTIs; combination of NRTIs, protease inhibitors, and ritonavir; combination of NRTIs and other classes. Multiple linear regression analysis determined the effect of the treatment regimen, time of use, and compliance with the regimen, on vitamin A and beta-carotene concentrations, controlling for the following variables: gender, age, educational level, smoking, physical activity, body mass index, time of infection with HIV, presence of comorbidities, CD4(+) T lymphocyte count, total cholesterol and fractions, and triglyceride levels. There was no significant difference in vitamin A or beta-carotene concentrations in patients under the different HAART regimens. However, approximately 4% of the patients had deficient/low concentrations of vitamin A (<0.70 mu mol/L), and 98% showed concentrations of beta-carotene <1.0 mu mol/L. In conclusion, HIV/AIDS patients in this region will not benefit from vitamin A supplementation, independently of the HAART regimen utilized, but beta-carotene may be of importance, considering its antioxidant effect.
Palavras-chave
HIV infection, HAART, vitamin A, beta-carotene, micronutrients
Referências
- Allard JP, 1998, AIDS, V12, P1653, DOI 10.1097/00002030-199813000-00013
- ARNAUD J, 1991, J CHROMATOGR-BIOMED, V572, P103, DOI 10.1016/0378-4347(91)80476-S
- Austin J, 2006, EUR J CLIN NUTR, V60, P1266, DOI 10.1038/sj.ejcn.1602447
- Baeten JM, 2007, INT J STD AIDS, V18, P202, DOI 10.1258/095646207780132541
- Baranowitz SA, 1996, AIDS, V10, P115
- Cartmel B, 2005, EUR J CLIN NUTR, V59, P1173, DOI 10.1038/sj.ejcn.1602229
- Drain PK, 2007, AM J CLIN NUTR, V85, P333
- Dumitrescu L, 2012, HUM GENET, V131, P1699, DOI 10.1007/s00439-012-1186-y
- Falcone EL, 2010, AM J CLIN NUTR, V91, P1213, DOI 10.3945/ajcn.2009.28816
- Farhangi MA, 2013, ANN CLIN BIOCHEM, V50, P25, DOI 10.1258/acb.2012.012096
- GEY KF, 1987, AM J CLIN NUTR, V45, P1368
- Gianetti J, 2002, AM HEART J, V143, P467, DOI 10.1067/mhj.2002.120776
- Irlam JH, 2010, COCHRANE DB SYST REV, V8
- Kaiser JD, 2006, JAIDS-J ACQ IMM DEF, V42, P523, DOI 10.1097/01.qai.0000230529.25083.42
- Klor HU, 2011, J DTSCH DERMATOL GES, V9, P600, DOI 10.1111/j.1610-0387.2011.07637.x
- Monteiro JP, 2009, NUTR RES, V29, P716, DOI 10.1016/j.nutres.2009.10.001
- Monteiro JP, 2000, NUTRITION, V16, P339
- MS, 2011, MS B EP AIDS DST
- National Institutes of Health, 2001, NIH PUBLICATION
- Nemes MIB, 2004, AIDS, V18, pS15, DOI 10.1097/01.aids.0000131315.44902.59
- Ngondi JL, 2006, AIDS RES THER, V22, P19
- NIH, 2006, GUID US ANT AG HIV 1
- Nimmagadda AP, 1998, CLIN INFECT DIS, V27, P1311, DOI 10.1086/514990
- ROSS AC, 1992, P SOC EXP BIOL MED, V200, P303
- Rousseau MC, 2000, ANN NUTR METAB, V44, P212, DOI 10.1159/000046686
- Scevola D, 2000, AIDS Read, V10, P365
- Schleicher RL, 2013, J NUTR, V143, p966S, DOI 10.3945/jn.112.172965
- SEMBA RD, 1995, J INFECT DIS, V171, P1196
- Sen SK, 2000, CURR TOP CELL REGUL, V36, P1
- Sheehan NL, 2012, MOLECULES, V17, P688, DOI 10.3390/molecules17010688
- Silveira S A, 1999, Rev Soc Bras Med Trop, V32, P119, DOI 10.1590/S0037-86821999000200001
- Singhal Neera, 2002, J Int Assoc Physicians AIDS Care (Chic), V1, P63, DOI 10.1177/154510970200100205
- Tang AM, 2005, AIDS, V19, P847, DOI 10.1097/01.aids.0000171398.77500.a9
- Tang AM, 1997, AIDS, V11, P613, DOI 10.1097/00002030-199705000-00009
- Tang AM, 2000, J ACQ IMMUN DEF SYND, V23, P321
- ULLRICH R, 1994, AIDS, V8, P661, DOI 10.1097/00002030-199405000-00013
- World Health Organization, 2000, OB PREV MAN GLOB EP
- WHO, 2010, JOINT UN PROGR HIV A
- World Health Organization-WHO, 1996, WHO MICR SER
- Zulet MA, 2008, J NUTR SCI VITAMINOL, V54, P347, DOI 10.3177/jnsv.54.347