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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | BERTI, Denise A. | - |
dc.contributor.author | RUSSO, Lilian C. | - |
dc.contributor.author | CASTRO, Leandro M. | - |
dc.contributor.author | CRUZ, Lilian | - |
dc.contributor.author | GOZZO, Fabio C. | - |
dc.contributor.author | HEIMANN, Joel C. | - |
dc.contributor.author | LIMA, Fabio B. | - |
dc.contributor.author | OLIVEIRA, Ariclecio C. | - |
dc.contributor.author | ANDREOTTI, Sandra | - |
dc.contributor.author | PRADA, Patricia O. | - |
dc.contributor.author | HEIMANN, Andrea S. | - |
dc.contributor.author | FERRO, Emer S. | - |
dc.date.accessioned | 2013-07-30T14:42:00Z | - |
dc.date.available | 2013-07-30T14:42:00Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | PROTEOMICS, v.12, n.17, Special Issue, p.2668-2681, 2012 | - |
dc.identifier.issn | 1615-9853 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/520 | - |
dc.description.abstract | Intracellular peptides generated by the proteasome and oligopeptidases have been suggested to function in signal transduction and to improve insulin resistance in mice fed a high-caloric diet. The aim of this study was to identify specific intracellular peptides in the adipose tissue of Wistar rats that could be associated with the physiological and therapeutic control of glucose uptake. Using semiquantitative mass spectrometry and LC/MS/MS analyses, we identified ten peptides in the epididymal adipose tissue of the Wistar rats; three of these peptides were present at increased levels in rats that were fed a high-caloric Western diet (WD) compared with rats fed a control diet (CD). The results of affinity chromatography suggested that in the cytoplasm of epididymal adipose tissue from either WD or CD rats, distinctive proteins bind to these peptides. However, despite the observed increase in the WD animals, the evaluated peptides increased insulin-stimulated glucose uptake in 3T3-L1 adipocytes treated with palmitate. Thus, intracellular peptides from the adipose tissue of Wistar rats can bind to specific proteins and facilitate insulin-induced glucose uptake in 3T3-L1 adipocytes. | - |
dc.description.sponsorship | Brazilian National Research Council (CNPq) [559698/2009-7-Rede GENO-PROT] | - |
dc.description.sponsorship | University of Sao Paulo (NAPNA-USP) [2011.1.9333.1.3] | - |
dc.description.sponsorship | CNPq | - |
dc.description.sponsorship | Sao Paulo State Research Foundation (FAPESP) | - |
dc.language.iso | eng | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.relation.ispartof | Proteomics | - |
dc.rights | restrictedAccess | - |
dc.subject | Adipose tissue | - |
dc.subject | Biomedicine | - |
dc.subject | Insulin resistance | - |
dc.subject | Obesity | - |
dc.subject | Peptide-protein interaction | - |
dc.subject.other | coa-binding protein | - |
dc.subject.other | necrosis-factor-alpha | - |
dc.subject.other | thimet oligopeptidase | - |
dc.subject.other | mass-spectrometry | - |
dc.subject.other | saccharomyces-cerevisiae | - |
dc.subject.other | 3t3-l1 adipocytes | - |
dc.subject.other | glucose-uptake | - |
dc.subject.other | inhibitor dbi | - |
dc.subject.other | mouse-brain | - |
dc.subject.other | wild-type | - |
dc.title | Identification of intracellular peptides in rat adipose tissue: Insights into insulin resistance | - |
dc.type | article | - |
dc.rights.holder | Copyright WILEY-BLACKWELL | - |
dc.identifier.doi | 10.1002/pmic.201200051 | - |
dc.identifier.pmid | 22740317 | - |
dc.subject.wos | Biochemical Research Methods | - |
dc.subject.wos | Biochemistry & Molecular Biology | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.author.external | BERTI, Denise A.:Univ Sao Paulo, Dept Cell Biol & Dev, BR-0550800 Sao Paulo, Brazil | - |
hcfmusp.author.external | RUSSO, Lilian C.:Univ Sao Paulo, Dept Cell Biol & Dev, BR-0550800 Sao Paulo, Brazil | - |
hcfmusp.author.external | CASTRO, Leandro M.:Univ Sao Paulo, Dept Cell Biol & Dev, BR-0550800 Sao Paulo, Brazil | - |
hcfmusp.author.external | CRUZ, Lilian:Univ Sao Paulo, Dept Cell Biol & Dev, BR-0550800 Sao Paulo, Brazil | - |
hcfmusp.author.external | GOZZO, Fabio C.:Univ Estadual Campinas, Inst Chem, Sao Paulo, Brazil | - |
hcfmusp.author.external | LIMA, Fabio B.:Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo, Brazil | - |
hcfmusp.author.external | OLIVEIRA, Ariclecio C.:Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo, Brazil | - |
hcfmusp.author.external | ANDREOTTI, Sandra:Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo, Brazil | - |
hcfmusp.author.external | PRADA, Patricia O.:Univ Estadual Campinas, Inst Chem, Sao Paulo, Brazil | - |
hcfmusp.author.external | HEIMANN, Andrea S.:Proteimax Biotechnol LTDA, Sao Paulo, Brazil | - |
hcfmusp.author.external | FERRO, Emer S.:Univ Sao Paulo, Dept Cell Biol & Dev, BR-0550800 Sao Paulo, Brazil | - |
hcfmusp.description.beginpage | 2668 | - |
hcfmusp.description.endpage | 2681 | - |
hcfmusp.description.issue | 17 | - |
hcfmusp.description.issue | Special Issue | - |
hcfmusp.description.volume | 2012 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | WOS:000308098700009 | - |
hcfmusp.origem.id | 2-s2.0-84865563285 | - |
hcfmusp.publisher.city | HOBOKEN | - |
hcfmusp.publisher.country | USA | - |
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dc.description.index | MEDLINE | - |
hcfmusp.remissive.sponsorship | CNPq | - |
hcfmusp.remissive.sponsorship | FAPESP | - |
hcfmusp.remissive.sponsorship | USP | - |
hcfmusp.lim.ref | 2012 | - |
hcfmusp.citation.scopus | 42 | - |
hcfmusp.scopus.lastupdate | 2024-04-12 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MCM Artigos e Materiais de Revistas Científicas - LIM/16 |
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