Hypocaloric high-protein diet improves clinical and biochemical markers in patients with nonalcoholic fatty liver disease (NAFLD)

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art_DUARTE_Hypocaloric_high_protein_diet_improves_clinical_and_biochemical_2014.PDF (112.41 KB)
Citações na Scopus
32
Tipo de produção
article
Data de publicação
2014
DOI
SciELO
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
AULA MEDICA EDICIONES
Autores
VANNI, Denise
Citação
NUTRICION HOSPITALARIA, v.29, n.1, p.94-101, 2014
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Objective: To investigate the role of hypocaloric high-protein diet, a prospective clinical study was conducted in NAFLD patients. Research methods and procedures: Pre-versus post-interventional data were analyzed in 48 stable NAFLD patients (submitted to a hypocaloric high-protein diet during 75 days. Variables included anthropometrics (body mass index/ BMI and waist circumference/WC), whole-body and segmental bioimpedance analysis and biochemical tests. Diet compliance was assessed by interviews every two weeks. Results: BMI, WC and body fat mass remained relatively stable (-1.3%, -1.8% and -2.5% respectively, no significance). HDL- cholesterol increased (P < 0.05) whereas total, LDL and VLDL cholesterol, triglycerides, aspartate aminotransferase/AST, gamma glutamyltransferase/GGT, alkaline phosphatase/AP, fasting blood glucose and glycated hemoglobin/HbA1c decreased (P < 0.05). When patients were stratified according to increase (22/48, 45.8%) and decrease (21/48, 43.8%) of BMI, association between weight decrease and liver benefit could be elicited in such circumstances for ALT, AP and AST/ALT ratio. No change could be demonstrated in patients who gained weight. Multivariate assessment confirmed that waist circumference, ferritin, triacylglycerol, and markers of glucose homeostasis were the most relevant associated with liver enzymes. Discussion: Ours results are consistent with the literature of calorie restriction in the management of NAFLD. Changes in lifestyle and weight loss are recommended for NAFLD patients. European guidelines also support this recommendation. Conclusion: This is the first study that demonstrated that a high protein, hypocaloric diet were associated with improvement of lipid profile, glucose homeostasis and liver enzymes in NAFLD independent on BMI decrease or body fat mass reduction.
Palavras-chave
NAFLD, Hypocaloric diet, Hyperproteic diet, Liver enzymes
URI
https://observatorio.fm.usp.br/handle/OPI/5385
Referências
  1. Angulo P, 2007, NUTR REV, V65, pS57, DOI 10.1301/nr.2007.jun.S57-S63
  2. Bortolotti M, 2011, CLIN NUTR, V30, P494, DOI 10.1016/j.clnu.2011.01.006
  3. Browning JD, 2004, HEPATOLOGY, V40, P1387, DOI 10.1002/hep.20466
  4. Burza MA, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0060495
  5. Catalano D, 2008, LIVER INT, V28, P1280, DOI 10.1111/j.1478-3231.2008.01742.x
  6. Cave M, 2007, J NUTR BIOCHEM, V18, P184, DOI 10.1016/j.jnutbio.2006.12.006
  7. Chalasani N, 2012, GASTROENTEROLOGY, V142, P1592, DOI 10.1053/j.gastro.2012.04.001
  8. Clifton PM, 2008, AM J CLIN NUTR, V87, P23
  9. de Luis DA, 2010, NUTR HOSP, V25, P730, DOI 10.3305/nh.2010.25.5.4643
  10. de Luis DA, 2008, DIABETES RES CLIN PR, V79, P74, DOI 10.1016/j.diabres.2007.07.015
  11. de Wit NJW, 2012, J HEPATOL, V57, P1370, DOI 10.1016/j.jhep.2012.07.003
  12. Dixon JB, 2006, OBES SURG, V16, P1278, DOI 10.1381/096089206778663805
  13. Ellrott Thomas, 2013, MMW Fortschr Med, V155, P49
  14. Grundy SM, 2004, ARTERIOSCL THROM VAS, V24, pE19, DOI 10.1161/01.ATV.0000112379.88385.67
  15. Haufe S, 2011, HEPATOLOGY, V53, P1504, DOI 10.1002/hep.24242
  16. Haukeland JW, 2005, SCAND J GASTROENTERO, V40, P1469, DOI 10.1080/00365520500264953
  17. Huang MA, 2005, AM J GASTROENTEROL, V100, P1072, DOI 10.1111/j.1572-0241.2005.41334.x
  18. Kang HL, 2006, AM J GASTROENTEROL, V101, P2247, DOI 10.1111/j.1572-0241.2006.00719.x
  19. LEAN MEJ, 1995, BRIT MED J, V311, P158
  20. Maersk M, 2012, AM J CLIN NUTR, V95, P283, DOI 10.3945/ajcn.111.022533
  21. MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
  22. McCarthy EM, 2012, J ACAD NUTR DIET, V112, P401, DOI 10.1016/j.jada.2011.10.007
  23. Oliveira LPM, 2012, NUTR HOSP, V27, P991, DOI 10.3305/nh.2012.27.4.5833
  24. Peng LJ, 2011, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003619.pub3
  25. Ratziu V, 2010, J HEPATOL, V53, P372, DOI 10.1016/j.jhep.2010.04.008
  26. Sacks FM, 2009, NEW ENGL J MED, V360, P859, DOI 10.1056/NEJMoa0804748
  27. Scaglioni F, 2012, CLIN RES HEPATOL GAS
  28. Schugar RC, 2012, CURR OPIN CLIN NUTR, V15, P374, DOI 10.1097/MCO.0b013e3283547157
  29. Schwarz J, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047303
  30. Shapiro JR, 2012, PREV MED, V55, P412, DOI 10.1016/j.ypmed.2012.08.011
  31. St George Alexis, 2009, J Gastroenterol Hepatol, V24, P399, DOI 10.1111/j.1440-1746.2008.05694.x
  32. Utzschneider KM, 2013, BRIT J NUTR, V109, P1096, DOI 10.1017/S0007114512002966
  33. Utzschneider KM, 2006, J CLIN ENDOCR METAB, V91, P4753, DOI 10.1210/jc.2006-0587
  34. Vilar L, 2008, NUTRITION, V24, P1097, DOI 10.1016/j.nut.2008.05.017
  35. Wycherley TP, 2013, EUR J NUTR, V52, P317, DOI 10.1007/s00394-012-0338-0
  36. Yasutake K, 2012, GASTROENT RES PRACT, DOI 10.1155/2012/859697
  37. Zivkovic AM, 2007, AM J CLIN NUTR, V86, P285

Coleções
Artigos e Materiais de Revistas Científicas - FM/MGT
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/07