Synergistic effects of childhood adversity and polygenic risk in first-episode psychosis: the EU-GEI study

Imagem de Miniatura
Arquivos
art_AAS_Synergistic_effects_of_childhood_adversity_and_polygenic_risk_2023.PDF (331.58 KB)
Citações na Scopus
8
Tipo de produção
article
Data de publicação
2023
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
CAMBRIDGE UNIV PRESS
Autores
AAS, Monica
ALAMEDA, Luis
FORTI, Marta Di
QUATTRONE, Diego
DAZZAN, Paola
TROTTA, Antonella
FERRARO, Laura
RODRIGUEZ, Victoria
VASSOS, Evangelos
SHAM, Pak
Citação
PSYCHOLOGICAL MEDICINE, v.53, n.5, p.1970-1978, 2023
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background A history of childhood adversity is associated with psychotic disorder, with an increase in risk according to the number of exposures. However, it is not known why only some exposed individuals go on to develop psychosis. One possibility is pre-existing polygenic vulnerability. Here, we investigated, in the largest sample of first-episode psychosis (FEP) cases to date, whether childhood adversity and high polygenic risk scores for schizophrenia (SZ-PRS) combine synergistically to increase the risk of psychosis, over and above the effect of each alone. Methods We assigned a schizophrenia-polygenic risk score (SZ-PRS), calculated from the Psychiatric Genomics Consortium (PGC2), to all participants in a sample of 384 FEP patients and 690 controls from the case-control component of the EU-GEI study. Only participants of European ancestry were included in the study. A history of childhood adversity was collected using the Childhood Trauma Questionnaire (CTQ). Synergistic effects were estimated using the interaction contrast ratio (ICR) [odds ratio (OR)(exposure and PRS) - ORexposure - ORPRS + 1] with adjustment for potential confounders. Results There was some evidence that the combined effect of childhood adversities and polygenic risk was greater than the sum of each alone, as indicated by an ICR greater than zero [i.e. ICR 1.28, 95% confidence interval (CI) -1.29 to 3.85]. Examining subtypes of childhood adversities, the strongest synergetic effect was observed for physical abuse (ICR 6.25, 95% CI -6.25 to 20.88). Conclusions Our findings suggest possible synergistic effects of genetic liability and childhood adversity experiences in the onset of FEP, but larger samples are needed to increase precision of estimates.
Palavras-chave
Childhood trauma, first-episode psychosis, interaction contrast ratio, polygenic risk, schizophrenia, synergistic effects
URI
https://observatorio.fm.usp.br/handle/OPI/54000
Referências
  1. Aas M, 2020, BIPOLAR DISORD, V22, P174, DOI 10.1111/bdi.12851
  2. Aas M, 2019, SCHIZOPHR RES, V213, P65, DOI 10.1016/j.schres.2019.01.011
  3. Aas M, 2016, INT J BIPOLAR DISORD, V4, DOI 10.1186/s40345-015-0042-0
  4. Aas M, 2014, J PSYCHIATR RES, V59, P14, DOI 10.1016/j.jpsychires.2014.08.011
  5. Arango C, 2017, EUR ARCH PSY CLIN N, V267, P1, DOI 10.1007/s00406-016-0765-7
  6. Baldwin JR, 2019, JAMA PSYCHIAT, V76, P584, DOI 10.1001/jamapsychiatry.2019.0097
  7. BERNSTEIN DP, 1994, AM J PSYCHIAT, V151, P1132, DOI 10.1176/ajp.151.8.1132
  8. Charlson FJ, 2018, SCHIZOPHRENIA BULL, V44, P1195, DOI 10.1093/schbul/sby058
  9. Church C, 2017, FRONT PSYCHOL, V8, DOI 10.3389/fpsyg.2017.01276
  10. Croft J, 2019, JAMA PSYCHIAT, V76, P79, DOI 10.1001/jamapsychiatry.2018.3155
  11. DEUTCH AY, 1990, BRAIN RES, V521, P311, DOI 10.1016/0006-8993(90)91557-W
  12. Di Forti M, 2019, LANCET PSYCHIAT, V6, P427, DOI 10.1016/S2215-0366(19)30048-3
  13. Dudbridge F, 2013, PLOS GENET, V9, DOI 10.1371/journal.pgen.1003348
  14. Egerton A, 2016, SCHIZOPHR RES, V176, P171, DOI 10.1016/j.schres.2016.06.005
  15. Garety PA, 2007, PSYCHOL MED, V37, P1377, DOI 10.1017/S003329170700013X
  16. Gayer-Anderson C, 2020, SOC PSYCH PSYCH EPID, V55, P645, DOI 10.1007/s00127-020-01831-x
  17. Guloksuz S, 2019, WORLD PSYCHIATRY, V18, P173, DOI 10.1002/wps.20629
  18. Hilker R, 2018, BIOL PSYCHIAT, V83, P492, DOI 10.1016/j.biopsych.2017.08.017
  19. HOSMER DW, 1992, EPIDEMIOLOGY, V3, P452, DOI 10.1097/00001648-199209000-00012
  20. Howes Oliver D, 2014, Lancet, V383, P1677, DOI 10.1016/S0140-6736(13)62036-X
  21. Jongsma HE, 2018, JAMA PSYCHIAT, V75, P36, DOI 10.1001/jamapsychiatry.2017.3554
  22. Kapur S, 2005, SCHIZOPHR RES, V79, P59, DOI 10.1016/j.schres.2005.01.003
  23. Knol MJ, 2007, INT J EPIDEMIOL, V36, P1111, DOI 10.1093/ije/dym157
  24. Knol MJ, 2012, INT J EPIDEMIOL, V41, P514, DOI 10.1093/ije/dyr218
  25. Lecei A, 2019, SCHIZOPHR RES, V205, P58, DOI 10.1016/j.schres.2018.05.025
  26. Lewis CM, 2017, GENOME MED, V9, DOI 10.1186/s13073-017-0489-y
  27. Mallett R, 2002, SOC PSYCH PSYCH EPID, V37, P329, DOI 10.1007/s00127-002-0557-4
  28. MCGUFFIN P, 1991, ARCH GEN PSYCHIAT, V48, P764
  29. Modinos G, 2013, SCHIZOPHR RES, V150, P356, DOI 10.1016/j.schres.2013.09.010
  30. Mullins N, 2016, PSYCHOL MED, V46, P759, DOI 10.1017/S0033291715002172
  31. Newbury JB, 2018, J PSYCHIATR RES, V96, P57, DOI 10.1016/j.jpsychires.2017.09.020
  32. Pardinas AF, 2019, NAT GENET, V51, P1193, DOI 10.1038/s41588-019-0450-7
  33. Peyrot WJ, 2018, BIOL PSYCHIAT, V84, P138, DOI 10.1016/j.biopsych.2017.09.009
  34. Peyrot WJ, 2014, BRIT J PSYCHIAT, V205, P113, DOI 10.1192/bjp.bp.113.143081
  35. Pruessner M, 2017, NEUROSCI BIOBEHAV R, V73, P191, DOI 10.1016/j.neubiorev.2016.12.013
  36. Purcell SM, 2009, NATURE, V460, P748, DOI 10.1038/nature08185
  37. Quattrone D, 2019, PSYCHOL MED, V49, P1378, DOI 10.1017/S0033291718002131
  38. Rajkumar RP, 2014, MED HYPOTHESES, V83, P276, DOI 10.1016/j.mehy.2014.05.017
  39. Reuben A, 2016, J CHILD PSYCHOL PSYC, V57, P1103, DOI 10.1111/jcpp.12621
  40. Ripke S, 2014, NATURE, V511, P421, DOI 10.1038/nature13595
  41. Shevlin M, 2008, SCHIZOPHRENIA BULL, V34, P193, DOI 10.1093/schbul/sbm069
  42. Sidebotham P, 2001, CHILD ABUSE NEGLECT, V25, P1177, DOI 10.1016/S0145-2134(01)00261-7
  43. Tesli M, 2014, ACTA PSYCHIAT SCAND, V130, P311, DOI 10.1111/acps.12307
  44. Torrey EF, 2002, BIOL PSYCHIAT, V52, P843
  45. Trotta A, 2019, SCHIZOPHR RES, V205, P51, DOI 10.1016/j.schres.2018.04.010
  46. Trotta A, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0163319
  47. van Winkel R, 2013, CAN J PSYCHIAT, V58, P44, DOI 10.1177/070674371305800109
  48. VanderWeele TJ., 2014, EPIDEMIOL METHODS, V3, P5, DOI [DOI 10.1515/EM-2013-0005, DOI 10.1515/EM-2013-0005/HTML, 10.1515/em-2013-0005]
  49. Varese F, 2012, SCHIZOPHRENIA BULL, V38, P661, DOI 10.1093/schbul/sbs050
  50. Vassos E, 2017, BIOL PSYCHIAT, V81, P470, DOI 10.1016/j.biopsych.2016.06.028
  51. Walker EF, 1997, PSYCHOL REV, V104, P667, DOI 10.1037/0033-295X.104.4.667
  52. Zheutlin AB, 2019, AM J PSYCHIAT, V176, P846, DOI 10.1176/appi.ajp.2019.18091085

Coleções
Artigos e Materiais de Revistas Científicas - FM/MPR
Artigos e Materiais de Revistas Científicas - LIM/39
Artigos e Materiais de Revistas Científicas - ODS/16