Can domestic dogs be considered a good reservoir of Leishmania (L.) infantum chagasi in an endemic area of nonulcerated cutaneous leishmaniasis in Southern Honduras?
Carregando...
Citações na Scopus
0
Tipo de produção
article
Data de publicação
2023
Título da Revista
ISSN da Revista
Título do Volume
Editora
INST MEDICINA TROPICAL SAO PAULO
Autores
SEGURA, Gabriela Beatriz Rodriguez
OCHOA, Wilfredo Humberto Sosa
MARTINEZ, Mercedes
TERCERO, Carol Rodriguez
GONZALEZ, Raquel Romero
SILVEIRA, Fernando Tobias
HENRIQUEZ, Maria Mercedes Rueda
Citação
REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO, v.65, article ID e24, 8p, 2023
Resumo
Dogs are considered to be the main domestic reservoir associated with the transmission of Leishmania (L.) infantum chagasi to humans in endemic areas of visceral leishmaniasis in America. However, little is known about the role of canines as a source of infection in endemic areas of nonulcerated cutaneous leishmaniasis (NUCL). Therefore, the objective of the present study was to investigate the role of dogs as a possible reservoir of the parasite in Southern Honduras. Dogs (n = 107) living with individuals affected by NUCL were clinically examined and biological material was collected for parasitological and immunological diagnosis. Most animals showed a healthy appearance and a few presented slight weight loss (64%), alopecia (7%), onychogryphosis (5%) and skin lesions (1%). The overall seroprevalence of Leishmania infection based on the DDP (R) quick test and/or in-house ELISA serological test was 41%. The presence of the parasite's DNA was confirmed in 94% of the dogs; however, the average parasite load in the buffy coat was low at 6.09 parasites/mu L, ranging between 0.221 and 50.2. The skin of seropositive dogs examined by histopathology using paraffin sections stained by hematoxylin and immunohistochemistry did not show cutaneous lesions or parasite amastigotes. Based on the absence of parasites in the skin and the low parasite load detected in the buffy coat, it seems that the dog does not represent a good source of infection for the vector in the endemic area of NUCL transmission in Southern Honduras. Other domestic and/or wild animals should be investigated.
Palavras-chave
Canine leishmaniasis, Leishmania (L, ) infantum chagasi, Nonulcerated cutaneous leishmaniasis, Diagnosis, Honduras
Referências
- Flores GVA, 2018, MEDIAT INFLAMM, V2018, DOI 10.1155/2018/3487591
- Soares MRA, 2011, ACTA TROP, V117, P6, DOI 10.1016/j.actatropica.2010.08.015
- Aschar M, 2016, VET PARASITOL, V225, P108, DOI 10.1016/j.vetpar.2016.06.005
- Baneth G, 2008, TRENDS PARASITOL, V24, P324, DOI 10.1016/j.pt.2008.04.001
- de Queiroz NMGP, 2011, VET PARASITOL, V178, P1, DOI 10.1016/j.vetpar.2010.12.033
- Flores GVA, 2023, PARASITOL INT, V93, DOI 10.1016/j.parint.2022.102723
- Instituto de Enfermedades Infecciosas y Parasitologia Antonio Vidal, 2009, MAN MAN ENF PAR PRIO, V2a
- Laranjeira DF, 2014, REV SAUDE PUBL, V48, P563, DOI 10.1590/S0034-8910.2014048005224
- Laurenti MD, 2014, VET PARASITOL, V205, P444, DOI 10.1016/j.vetpar.2014.09.002
- Laurenti MD, 2013, VET PARASITOL, V196, P296, DOI 10.1016/j.vetpar.2013.03.017
- MANCIANTI F, 1988, T ROY SOC TROP MED H, V82, P566, DOI 10.1016/0035-9203(88)90510-X
- Michalsky EM, 2007, VET PARASITOL, V147, P67, DOI 10.1016/j.vetpar.2007.03.004
- Moreira MAB, 2007, VET PARASITOL, V145, P245, DOI 10.1016/j.vetpar.2006.12.012
- Padgett D, 2009, REV MED HONDUR, V77, P7
- Paltrinieri S, 2010, JAVMA-J AM VET MED A, V236, P1184, DOI 10.2460/javma.236.11.1184
- PONCE C, 1991, LANCET, V337, P67, DOI 10.1016/0140-6736(91)90734-7
- Rossi CN, 2016, REV INST MED TROP SP, V58, DOI [10.1590/S1678-9946201658048, 10.1590/s1678-9946201658048]
- Sandoval C, 2021, J VENOM ANIM TOXINS, V27, DOI [10.1590/1678-9199-JVATITD-2020-0149, 10.1590/1678-9199-jvatitd-2020-0149]
- Pacheco CMS, 2021, J IMMUNOL RES, V2021, DOI 10.1155/2021/5596876
- Pacheco CMS, 2018, INT J EXP PATHOL, V99, P249, DOI 10.1111/iep.12295
- Silveira FT, 2012, PARASITOL RES, V111, P1513, DOI 10.1007/s00436-012-2989-4
- Silveira FT, 2023, MICROORGANISMS, V11, DOI 10.3390/microorganisms11010025
- Silveira FT, 2021, MICROBIOL RESOUR ANN, V10, DOI 10.1128/MRA.00471-21
- Silveira Fernando Tobias, 2010, Revista Pan-Amazonica de Saude, V1, P143
- Solano-Gallego L, 2001, VET PARASITOL, V96, P265, DOI 10.1016/S0304-4017(00)00446-5
- Sosa-Ochoa W, 2020, PARASITE VECTOR, V13, DOI 10.1186/s13071-020-04462-y
- Sosa-Ochoa W, 2020, PATHOGENS, V9, DOI 10.3390/pathogens9070554
- Vercosa BLA, 2008, BMC VET RES, V4, DOI 10.1186/1746-6148-4-45