Late-onset obsessive-compulsive disorder: Risk factors and correlates

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art_SHAVITT_Late_onset_obsessive_compulsive_disorder_Risk_factors_and_2014.PDF (435.72 KB)
Citações na Scopus
25
Tipo de produção
article
Data de publicação
2014
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
PERGAMON-ELSEVIER SCIENCE LTD
Autores
FRYDMAN, Ilana
BRASIL, Pedro E. do
TORRES, Albina R.
FERRAO, Ygor A.
ROSARIO, Maria C.
FONTENELLE, Leonardo F.
Citação
JOURNAL OF PSYCHIATRIC RESEARCH, v.49, p.68-74, 2014
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background: While a great amount of attention has been paid to early-onset obsessive-compulsive disorder (OCD), there is a dearth of studies on patients showing OCD for the first time at later stages of life. In this study, we aimed at determining possible risk factors/correlates for OCD onset at or after age 40, here termed late-onset OCD. Method: A series of models including several potential variables associated with late onset OCD were tested using a monolayer neural network. To this regard, data from the Brazilian Research Consortium of Obsessive-Compulsive Spectrum Disorders (CTOC) (n = 1001) was employed. For the purposes of this study, we considered a diagnosis of late onset OCD to be present whenever distress and interference associated with OCD symptoms emerged at or after age 40. Different nested models were compared through the Akaike Criteria keeping the variables with p value <= 0.05. Results: Late-onset OCD occurred in 8.6% of the sample. A model including female sex, a history of chronic (>10 years) subclinical obsessive-compulsive symptoms, the co-occurrence of posttraumatic stress disorder (PTSD) after age 40, and a history of recent pregnancy in self or significant others was able to explain a sizeable proportion of late-onset OCD. The general performance of this model, represented by the Maximum Likelihood R2, was 29.4%. Conclusion: Our results suggest that late-onset OCD is more likely to occur in females, in individuals with long periods of subclinical obsessive-compulsive symptoms, and in association with a major traumatic event occurring after age 40 and a history of recent pregnancy in self or in significant others.
Palavras-chave
Obsessive-compulsive disorder, Clinical course, Onset, Late-onset, Phenotype
URI
https://observatorio.fm.usp.br/handle/OPI/5436
Referências
  1. Akaike H, 1969, I STAT MATH, P243
  2. Albert U, 2002, PSYCHOPATHOLOGY, V35, P8, DOI 10.1159/000056210
  3. Alvarenga P d, 2009, GEN HOSP PSYCHIAT, V31, P178
  4. Basile LV, 1996, J AM ACAD CHILD ADOL, V35, P898
  5. Bhattacharyya S, 2004, AUST NZ J PSYCHIAT, V38, P477, DOI 10.1111/j.1440-1614.2004.01397.x
  6. Coles ME, 2011, BEHAV COGN PSYCHOTH, V39, P579, DOI 10.1017/S135246581100004X
  7. Cunha JA, 2001, MANUAL VERSAO PORTUG
  8. Eisen JL, 1998, AM J PSYCHIAT, V155, P102
  9. Ferrao YA, 2006, J AFFECT DISORDERS, V94, P199, DOI 10.1016/j.jad.2006.04.019
  10. First MB, 1997, STRUCTURED CLIN INTE
  11. Fontenelle LF, 2012, J ANXIETY DISORD, V26, P377, DOI 10.1016/j.janxdis.2011.12.001
  12. Fontenelle LF, 2011, NEUROPSYCHIATRY-LOND, V1, P61, DOI 10.2217/NPY.10.1
  13. Fontenelle LF, 2008, PROG NEURO-PSYCHOPH, V32, P1, DOI 10.1016/j.pnpbp.2007.06.04
  14. Fontenelle Leonardo, 2002, Revista Brasileira de Psiquiatria, V24, P7, DOI 10.1590/S1516-44462002000100005
  15. Forray A, 2010, J CLIN PSYCHIAT, V71, P1061, DOI 10.4088/JCP.09m05381blu
  16. Frydman I, 2010, COGN BEHAV NEUROL, V23, P205, DOI 10.1097/WNN.0b013e3181e61ce0
  17. Fullana MA, 2009, AM J PSYCHIAT, V166, P329, DOI [10.1176/appi.ajp.2008.08071006, 10.1176/appi.ajp.2008/08071006]
  18. Gittleson N, 1996, BRIT J PSYCHIAT, V112, P261
  19. Gittleson N, 1996, BRIT J PSYCHIAT, V112, P705
  20. GOODMAN WK, 1989, ARCH GEN PSYCHIAT, V46, P1012
  21. Gordon I, 2010, BIOL PSYCHIAT, V68, P377, DOI 10.1016/j.biopsych.2010.02.005
  22. Grant JE, 2007, PSYCHIAT RES, V152, P21, DOI 10.1016/j.psychres.2006.09.015
  23. Murphy Dennis L, 2010, Dialogues Clin Neurosci, V12, P131
  24. Grisham JR, 2011, PSYCHOL MED, V41, P2495, DOI 10.1017/S0033291711000894
  25. Koran L, 1999, OBSESSIVE COMPULSIVE
  26. Mathis Maria Alice de, 2011, Rev Bras Psiquiatr, V33, P390
  27. Miguel EC, 2008, REV BRAS PSIQUIATR, V30, P185, DOI 10.1590/S1516-44462008000300003
  28. Moraes Edson Capone de Jr, 2008, Rev Bras Psiquiatr, V30, P291
  29. Petribu K, 2011, REV BRAS PSIQUIATR, V33, P211, DOI 10.1590/S1516-44462011000200019
  30. Quarantini L, 2011, COMPR PSYCHIAT, V52, P386
  31. Rosario MC, 2009, CNS SPECTRUMS, V14, P315
  32. Rosario-Campos MC, 2006, MOL PSYCHIATR, V11, P495, DOI 10.1038/sj.mp.4001798
  33. Rosario-Campos MC, 2005, AM J MED GENET B, V136B, P92
  34. Rosario-Campos M C, 2001, Am J Psychiatry, V158, P1899
  35. Roussos A, 2003, EUR CHILD ADOLES PSY, V12, P58, DOI 10.1007/s00787-003-0308-4
  36. Ryu S, 2011, AM J MED GENET B, V156B, P949, DOI 10.1002/ajmg.b.31242
  37. Saltzman W, 2011, PROG NEURO-PSYCHOPH, V35, P1192, DOI 10.1016/j.pnpbp.2010.09.017
  38. Sekiyama T, 2013, PSYCHIAT RES, V209, P560, DOI 10.1016/j.psychres.2013.03.009
  39. Taylor S, 2011, CLIN PSYCHOL REV, V31, P1083, DOI 10.1016/j.cpr.2011.06.007
  40. Tolin DF, 2010, DEPRESS ANXIETY, V27, P829, DOI 10.1002/da.20684
  41. Torresan RC, 2009, COMPR PSYCHIAT, V50, P63, DOI 10.1016/j.comppsych.2008.05.005
  42. Viswanath B, 2011, PSYCHOPATHOLOGY, V44, P83, DOI 10.1159/000317776

Coleções
Artigos e Materiais de Revistas Científicas - FM/MPS
Artigos e Materiais de Revistas Científicas - HC/IPq
Artigos e Materiais de Revistas Científicas - LIM/21