Toward the optimal dose metric in continuous renal replacement therapy

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art_MACEDO_Toward_the_optimal_dose_metric_in_continuous_renal_2012.PDF (313.32 KB)
Citações na Scopus
21
Tipo de produção
article
Data de publicação
2012
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
WICHTIG EDITORE
Autores
GRANADO, Rolando Claure-Del
CHERTOW, Glenn M.
SOROKO, Sharon
HIMMELFARB, Jonathan
IKIZLER, T. Alp
PAGANINI, Emil P.
MEHTA, Ravindra L.
Citação
INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, v.35, n.6, p.413-424, 2012
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Purpose: There is no consensus on the optimal method to measure delivered dialysis dose in patients with acute kidney injury (AKI). The use of direct dialysate-side quantification of dose in preference to the use of formal blood-based urea kinetic modeling and simplified blood urea nitrogen (BUN) methods has been recommended for dose assessment in critically-ill patients with AKI. We evaluate six different blood-side and dialysate-side methods for dose quantification. Methods: We examined data from 52 critically-ill patients with AKI requiring dialysis. All patients were treated with pre-dilution CWHDF and regional citrate anticoagulation. Delivered dose was calculated using blood-side and dialysis-side kinetics. Filter function was assessed during the entire course of therapy by calculating BUN to dialysis fluid urea nitrogen (FUN) ratios q/12 hours. Results: Median daily treatment time was 1,413 min (1,260-1,440). The median observed effluent volume per treatment was 2,355 mL/h (2,060-2,863) (p<0.001). Urea mass removal rate was 13.0 +/- 7.6 mg/min. Both EKR (r(2)=0.250; p<0.001) and K-D (r(2)=0.409; p<0.001) showed a good correlation with actual solute removal. EKR and K-D presented a decline in their values that was related to the decrease in filter function assessed by the FUN/BUN ratio. Conclusions: Effluent rate (ml/kg/h) can only empirically provide an estimated of dose in CRRT. For clinical practice, we recommend that the delivered dose should be measured and expressed as K-D. EKR also constitutes a good method for dose comparisons over time and across modalities.
Palavras-chave
Dose, Clearance, Acute kidney injury
URI
https://observatorio.fm.usp.br/handle/OPI/5486
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Coleções
Artigos e Materiais de Revistas Científicas - HC/ICHC