Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/55040
Title: Carvacrol reduces blood pressure, arterial responsiveness and increases expression of MAS receptors in spontaneously hypertensive rats
Authors: DIAS, Carlos JoseCOSTA, Herikson AraujoDIAS-FILHO, Carlos Alberto AlvesFERREIRA, Andressa CoelhoRODRIGUES, BrunoIRIGOYEN, Maria ClaudiaBORGES, Antonio Carlos RomaoMARTINS, Vicenilma de AndadreVIDAL, Flavia Castello BrancoRIBEIRO, Rachel MeloSALGADO FILHO, NatalinoMOSTARDA, Cristiano T.
Citation: EUROPEAN JOURNAL OF PHARMACOLOGY, v.917, article ID 174717, 7p, 2022
Abstract: Aim: To analyze the effect of the use of carvacrol in the cardiovascular system of spontaneously hypertensive rats (SHR). Methods: Methods: Twenty animals were allocated in four groups, one group control Wistar receiving only sorbitol, used as vehicle of administration of the carvacrol (Wistar-Vehicle), one control group SHR, also receive only sorbitol (SHR-Vehicle), a third, treated with losartan (SHR-Losartan/50 mg/kg), and the fourth, treated with carvacrol (SHR - Carvacrol/20 mg/kg). Sorbitol, losartan and carvacrol were administered by oral gavage daily for 30-day. Hemodynamic variables, vascular reactivity, biochemical parameters, and expression of Mas and AT1 receptors in kidney tissues were analyzed. Results: SHR- Carvacrol group showed a maximal effect of inhibition of 56% in the curve of norepinephrine. The Emax of the curves with Ca2+ were smaller in the groups SHR-losartan (40.17%) and SHR-carvacrol (35.71%) when compared to the SHR-Vehicle. The carvacrol increased the expression of the MAS receptors in kidney tissue. Conclusion: Thirty days of treatment with carvacrol showed an antihypertensive effect associated with less peripheral vascular resistance. Also, treatment with carvacrol increased the expression of MAS receptors in kidney tissue.
Appears in Collections:

Artigos e Materiais de Revistas Científicas - HC/InCor
Instituto do Coração - HC/InCor

Artigos e Materiais de Revistas Científicas - LIM/05
LIM/05 - Laboratório de Poluição Atmosférica Experimental

Artigos e Materiais de Revistas Científicas - LIM/59
LIM/59 - Laboratório de Biologia Celular

Artigos e Materiais de Revistas Científicas - LIM/65
LIM/65 - Laboratório de Investigação Médica em Bioengenharia


Files in This Item:
File Description SizeFormat 
art_DIAS_Carvacrol_reduces_blood_pressure_arterial_responsiveness_and_increases_2022.PDF
  Restricted Access
publishedVersion (English)2.16 MBAdobe PDFView/Open Request a copy

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.