Still's disease continuum from childhood to elderly: data from the international AIDA Network Still's disease registry

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Citações na Scopus
2
Tipo de produção
article
Data de publicação
2023
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
BMJ PUBLISHING GROUP
Autores
VITALE, Antonio
CAGGIANO, Valeria
LOPALCO, Giuseppe
CICCIA, Francesco
ALMAGHLOUTH, Ibrahim A.
RUSCITTI, Piero
SFIKAKIS, Petros P.
TUFAN, Abdurrahman
DAGNA, Lorenzo
Citação
RMD OPEN, v.9, n.4, article ID e003578, 12p, 2023
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Objective Still's disease is more frequently observed in the paediatric context, but a delayed onset is not exceptional both in the adulthood and in the elderly. However, whether paediatric-onset, adult-onset and elderly-onset Still's disease represent expressions of the same disease continuum or different clinical entities is still a matter of controversy. The aim of this study is to search for any differences in demographic, clinical features and response to treatment between pediatric-onset, adult-onset and elderly-onset Still's disease. Methods Subjects included in this study were drawn from the International AutoInflammatory Disease Alliance Network registry for patients with Still's disease. Results A total of 411 patients suffering from Still's disease were enrolled; the disease occurred in the childhood in 65 (15.8%) patients, in the adult 314 (76.4%) patients and in the elderly in 32 (7.8%) patients. No statistically significant differences at post-hoc analysis were observed in demographic features of the disease between pediatric-onset, adult-onset and elderly-onset Still's disease. The salmon-coloured skin rash (p=0.004), arthritis (p=0.009) and abdominal pain (p=0.007) resulted significantly more frequent among paediatric patients than in adult cases, while pleuritis (p=0.015) and arthralgia (p<0.0001) were significantly more frequent among elderly-onset patients compared with paediatric-onset subjects. Regarding laboratory data, thrombocytosis was significantly more frequent among paediatric patients onset compared with adult-onset subjects (p<0.0001), while thrombocytopenia was more frequent among elderly-onset patients although statistical significance was only bordered. No substantial differences were observed in the response to treatments. Conclusions Despite some minor difference between groups, overall, demographic, clinical, laboratory and treatments aspects of Still's disease were similarly observed in patients at all ages. This supports that pediatric-onset, adult-onset and elderly-onset Still's disease is the same clinical condition arising in different ages.
Palavras-chave
Still's Disease, Adult-Onset, Epidemiology, Child
URI
https://observatorio.fm.usp.br/handle/OPI/58218
Referências
  1. Aicha B, 2023, CURR RHEUMATOL REV, V19, P235, DOI 10.2174/1573397118666220617101447
  2. Berardicurti O., 2021, Rheumatology, V60, P4844, DOI [10.1093/rheumatology/keaa904, DOI 10.1093/RHEUMATOLOGY/KEAA904]
  3. CUSH JJ, 1987, ARTHRITIS RHEUM, V30, P186, DOI 10.1002/art.1780300209
  4. Di Cola I, 2022, CLIN EXP RHEUMATOL, V40, P1517, DOI 10.55563/clinexprheumatol/0215kv
  5. Di Cola I, 2023, JOINT BONE SPINE, V90, DOI 10.1016/j.jbspin.2023.105576
  6. Dunger-Baldauf C, 2022, RHEUMATOL THER, V9, P753, DOI 10.1007/s40744-021-00422-9
  7. Efthimiou P, 2021, SEMIN ARTHRITIS RHEU, V51, P858, DOI 10.1016/j.semarthrit.2021.06.004
  8. Fardet L, 2014, ARTHRITIS RHEUMATOL, V66, P2613, DOI 10.1002/art.38690
  9. Fautrel B, 2002, MEDICINE, V81, P194, DOI 10.1097/00005792-200205000-00003
  10. Feist E, 2018, CLIN EXP RHEUMATOL, V36, P668
  11. Henter JI, 2007, PEDIATR BLOOD CANCER, V48, P124, DOI 10.1002/pbc.21039
  12. Inoue N, 2016, CLIN IMMUNOL, V169, P8, DOI 10.1016/j.clim.2016.05.010
  13. Jamilloux Y, 2015, IMMUNOL RES, V61, P53, DOI 10.1007/s12026-014-8561-9
  14. Kishida D, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-10932-3
  15. Kudela H, 2019, BMC RHEUMATOL, V3, DOI 10.1186/s41927-019-0053-z
  16. Lenert A, 2020, RHEUMATOLOGY, V59, P1788, DOI 10.1093/rheumatology/keaa154
  17. Li S, 2023, J TRANSL AUTOIMMUN, V6, DOI 10.1016/j.jtauto.2023.100196
  18. Martini A, 2019, J RHEUMATOL, V46, P190, DOI 10.3899/jrheum.180168
  19. Maruyama A, 2021, MOD RHEUMATOL, V31, P862, DOI 10.1080/14397595.2020.1829340
  20. Mollaeian A, 2021, BMC RHEUMATOL, V5, DOI 10.1186/s41927-021-00201-7
  21. Neau PA, 2022, J CLIN MED, V11, DOI 10.3390/jcm11226703
  22. Nirmala N, 2015, PEDIATR RHEUMATOL, V13, DOI 10.1186/s12969-015-0047-3
  23. Petty RE, 2004, J RHEUMATOL, V31, P390
  24. Ravelli A, 2016, ARTHRITIS RHEUMATOL, V68, P566, DOI 10.1002/art.39332
  25. Ruscitti P, 2022, CLIN RHEUMATOL, V41, P3597, DOI 10.1007/s10067-022-06357-y
  26. Ruscitti P, 2022, RHEUMATOLOGY, V61, P4124, DOI 10.1093/rheumatology/keac027
  27. Sugiyama T, 2022, ARTHRITIS RES THER, V24, DOI 10.1186/s13075-021-02708-3
  28. Suzuki E, 2021, TOHOKU J EXP MED, V255, P195, DOI 10.1620/tjem.255.195
  29. Vitale A., 2022, Front Med, V9, DOI [10.3389/fmed.2022.908501, DOI 10.3389/FMED.2022.908501]
  30. Yagishita M, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-25514-6
  31. YAMAGUCHI M, 1992, J RHEUMATOL, V19, P424

Coleções
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/17