https://observatorio.fm.usp.br/handle/OPI/729
Title: | Lack of evidence to support the association of a single IL28B genotype SNP rs12979860 with the HTLV-1 clinical outcomes and proviral load |
Authors: | SANABANI, Sabri Saeed; NUKUI, Youko; PEREIRA, Juliana; COSTA, Antonio Charlys da; OLIVEIRA, Ana Carolina Soares de; PESSOA, Rodrigo; LEAL, Fabio Eudes; SEGURADO, Aluisio C.; KALLAS, Esper Georges; SABINO, Ester Cerdeira |
Citation: | BMC INFECTIOUS DISEASES, v.12, article ID 374, 6p, 2012 |
Abstract: | Background: The Interleukin 28B (IL28B) rs12979860 polymorphisms was recently reported to be associated with the human T-cell leukemia virus type 1 (HTLV-1) proviral load (PvL) and the development of the HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Methods: In an attempt to examine this hypothesis, we assessed the association of the rs12979860 genotypes with HTLV-1 PvL levels and clinical status in 112 unrelated Brazilian subjects (81 HTLV-1 asymptomatic carriers, 24 individuals with HAM/TSP and 7 with Adult T cell Leukemia/Lymphoma (ATLL)). Results: All 112 samples were successfully genotyped and their PvLs compared. Neither the homozygote TT nor the heterozygote CT mutations nor the combination genotypes (TT/CT) were associated with a greater PvL. We also observed no significant difference in allele distribution between asymptomatic carriers and patients with HTLV-1 associated HAM/TSP. Conclusions: Our study failed to support the previously reported positive association between the IL28B rs12979860 polymorphisms and an increased risk of developing HAM/TSP in the Brazilian population. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MCM Artigos e Materiais de Revistas Científicas - FM/MIP Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - IMT Artigos e Materiais de Revistas Científicas - LIM/31 Artigos e Materiais de Revistas Científicas - LIM/52 Artigos e Materiais de Revistas Científicas - LIM/60 |
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art_SANABANI_Lack_of_evidence_to_support_the_association_of_2012.PDF | publishedVersion (English) | 306.12 kB | Adobe PDF | View/Open |
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