Pneumocystis jirovecii pneumonia with an atypical granulomatous response after kidney transplantation

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Arquivos
art_RAMALHO_Pneumocystis_jirovecii_pneumonia_with_an_atypical_granulomatous_response_2014.PDF (290.33 KB)
Citações na Scopus
15
Tipo de produção
article
Data de publicação
2014
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
WILEY-BLACKWELL
Autores
RAMALHO, J.
Citação
TRANSPLANT INFECTIOUS DISEASE, v.16, n.2, p.315-319, 2014
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Pneumocystis jirovecii pneumonia (PCP) continues to be a leading cause of morbidity and mortality in kidney transplant recipients. Granulomatous PCP is an unusual histological presentation that has been described in a variety of immunosuppressive conditions. Previous studies have demonstrated an association between granulomatous disorders and hypercalcemia, the purported mechanism of which is extrarenal production of 1,25-dihydroxyvitamin D by activated macrophages. Here, we report a case of granulomatous formation in a kidney transplant recipient with PCP who presented with hypercalcemia and suppressed parathyroid hormone, both of which resolved after successful treatment of the pneumonia. In immunocompromised patients, pulmonary infection associated with hypercalcemia should raise the suspicion of PCP and other granulomatous disorders.
Palavras-chave
hypercalcemia, Pneumocystis jirovecii, granuloma, kidney transplantation
URI
https://observatorio.fm.usp.br/handle/OPI/7310
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MCG
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/47
Artigos e Materiais de Revistas Científicas - ODS/03