Assessment of irradiated brain metastases using dynamic contrast-enhanced magnetic resonance imaging
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Citações na Scopus
23
Tipo de produção
article
Data de publicação
2014
Título da Revista
ISSN da Revista
Título do Volume
Editora
SPRINGER
Autores
PINHO, Marco C.
MEIRA-FREITAS, Daniel
Citação
NEURORADIOLOGY, v.56, n.6, p.437-443, 2014
Resumo
The purpose of this study was to evaluate the effect of stereotactic radiosurgery (SRS) on cerebral metastases using the transfer constant (K (trans)) assessed by dynamic contrast-enhanced (DCE) MRI. Furthermore, we aimed to evaluate the ability of K (trans) measurements to predict midterm tumor outcomes after SRS. The study received institutional review board approval, and informed consent was obtained from all subjects. Twenty-six adult patients with a total of 34 cerebral metastases underwent T1-weighted DCE MRI in a 1.5-T magnet at baseline (prior to SRS) and 4-8 weeks after treatment. Quantitative analysis of DCE MRI was performed by generating K (trans) parametric maps, and region-of-interest-based measurements were acquired for each metastasis. Conventional MRI was performed at least 16 weeks after SRS to assess midterm tumor outcome using volume variation. The mean (+/- SD) K (trans) value was 0.13 +/- 0.11 min(-1) at baseline and 0.08 +/- 0.07 min(-1) after 4-8 weeks post-treatment (p < 0.001). The mean (+/- SD) total follow-up time was 7.9 +/- 4.7 months. Seventeen patients (22 lesions) underwent midterm MRI. Of those, nine (41 %) lesions had progressed at the midterm follow-up. An increase in K (trans) after SRS was predictive of tumor progression (hazard ratio = 1.50; 95 % CI = 1.16-1.70, p < 0.001). An increase of 15 % in K (trans) showed a sensitivity of 78 % and a specificity of 85 % for the prediction of progression at midterm follow-up. SRS was associated with a reduction of K (trans) values of the cerebral metastases in the early post-treatment period. Furthermore, K (trans) variation as assessed using DCE MRI may be helpful to predict midterm outcomes after SRS.
Palavras-chave
Brain metastasis, MRI, Stereotactic radiosurgery, Brain tumor
Referências
- Cao Y, 2009, CLIN CANCER RES, V15, P1747, DOI 10.1158/1078-0432.CCR-08-1420
- Carr JP, 2007, MAGN RESON MED, V58, P281, DOI 10.1002/mrm.21317
- Essig M, 2003, RADIOLOGY, V228, P193, DOI 10.1148/radiol.2281020298
- Gao X, 2011, CHINESE MED J-PEKING, V124, P1906, DOI 10.3760/cma.j.issn.0366-6999.2011.12.025
- Huang CF, 2008, SURG NEUROL, V69, P62, DOI 10.1016/j.surneu.2007.02.021
- Huber PE, 2001, INT J RADIAT ONCOL, V49, P1339, DOI 10.1016/S0360-3016(00)01511-X
- Kang TW, 2009, EUR J RADIOL, V72, P370, DOI 10.1016/j.ejrad.2008.08.009
- Kassner A, 2011, METHODS MOL BIOL, V686, P229, DOI 10.1007/978-1-60761-938-3_10
- Lacerda S, 2009, NEUROIMAG CLIN N AM, V19, P527, DOI 10.1016/j.nic.2009.08.007
- Peng SL, 2012, NMR BIOMED
- Peterson AM, 1999, RADIOLOGY, V211, P807
- Provenzale JM, 2005, AM J ROENTGENOL, V185, P763
- Rahman M, 2012, STEREOT FUNCT NEUROS, V90, P69, DOI 10.1159/000334669
- Ranjan T, 2009, NEUROTHERAPEUTICS, V6, P598, DOI 10.1016/j.nurt.2009.04.012
- Ross DA, 2002, J NEURO-ONCOL, V56, P175, DOI 10.1023/A:1014571900854
- Shah R, 2012, RADIOGRAPHICS, V32, P1343, DOI 10.1148/rg.325125002
- Shinoda Jun, 2002, Brain Tumor Pathol, V19, P83, DOI 10.1007/BF02478932
- Suh JH, 2010, NEW ENGL J MED, V362, P1119, DOI 10.1056/NEJMct0806951
- Thompson G, 2010, NEUROIMAG CLIN N AM, V20, P337, DOI 10.1016/j.nic.2010.04.008
- TOFTS PS, 1991, MAGNET RESON MED, V17, P357, DOI 10.1002/mrm.1910170208
- Weltman E, 2000, INT J RADIAT ONCOL, V46, P1155, DOI 10.1016/S0360-3016(99)00549-0
- Zaharchuk G, 2007, AM J NEURORADIOL, V28, P1850, DOI 10.3174/ainr.A0831
- Zhang N, 2012, J MAGN RESON IMAGING, V36, P355, DOI 10.1002/jmri.23675