Tumor growth pattern as predictor of colorectal liver metastasis recurrence

Imagem de Miniatura
Arquivos
art_PINHEIRO_Tumor_growth_pattern_as_predictor_of_colorectal_liver_2014.PDF (520.94 KB)
Citações na Scopus
38
Tipo de produção
article
Data de publicação
2014
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
Autores
LAI, Quirino
Citação
AMERICAN JOURNAL OF SURGERY, v.207, n.4, p.493-498, 2014
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
BACKGROUND: Surgical resection is the gold standard therapy for the treatment of colorectal liver metastases (CRM). The aim of this study was to investigate the impact of tumor growth patterns on disease recurrence. METHODS: We enrolled 91 patients who underwent CRM resection. Pathological specimens were prospectively evaluated, with particular attention given to tumor growth patterns (infiltrative vs pushing). RESULTS: Tumor recurrence was observed in 65 patients (71.4%). According to multivariate analysis, 3 or more lesions (P = .05) and the infiltrative tumor margin type (P = .05) were unique independent risk factors for recurrence. Patients with infiltrative margins had a 5-year disease-free survival rate significantly inferior to patients with pushing margins (20.2% vs 40.5%, P = .05). CONCLUSIONS: CRM patients with pushing margins presented superior disease-free survival rates compared with patients with infiltrative margins. Thus, the adoption of the margin pattern can represent a tool for improved selection of patients for adjuvant treatment.
Palavras-chave
Colorectal neoplasms, Colorectal metastasis, Hepatectomy, Pathology, surgical, Recurrence
URI
https://observatorio.fm.usp.br/handle/OPI/7493
Referências
  1. Aloia Thomas A, 2011, Updates Surg, V63, P1, DOI 10.1007/s13304-011-0054-y
  2. Are C, 2007, ANN SURG, V246, P295, DOI 10.1097/SLA.0b013e31811ea962
  3. Cady B, 1998, ANN SURG, V227, P566, DOI 10.1097/00000658-199804000-00019
  4. de Haas RJ, 2008, ANN SURG, V248, P626, DOI 10.1097/SLA.0b013e31818a07f1
  5. de Haas RJ, 2011, ANN SURG, V253, P1069, DOI 10.1097/SLA.0b013e318217e898
  6. Elias D, 1998, EUR J SURG ONCOL, V24, P174, DOI 10.1016/S0748-7983(98)92878-5
  7. Figueras J, 2007, ANN ONCOL, V18, P1190, DOI 10.1093/annonc/mdm106
  8. HARRISON JC, 1994, HUM PATHOL, V25, P498, DOI 10.1016/0046-8177(94)90122-8
  9. Jass JR, 1996, HISTOPATHOLOGY, V28, P543, DOI 10.1046/j.1365-2559.1996.d01-467.x
  10. JASS JR, 1987, LANCET, V1, P1303
  11. Jemal A, 2008, CA-CANCER J CLIN, V58, P71, DOI 10.3322/CA.2007.0010
  12. Kato T, 2003, DIS COLON RECTUM, V46, pS22, DOI 10.1097/01.DCR.0000089106.71914.00
  13. Nagashima I, 1999, AM J GASTROENTEROL, V94, P739
  14. Nordlinger B, 2007, EUR J CANCER, V43, P2037, DOI 10.1016/j.ejca.2007.07.017
  15. Ott R, 2001, CHIRURG, V72, P887, DOI 10.1007/s001040170084
  16. Pawlik TM, 2005, ANN SURG, V241, P715, DOI 10.1097/01.sla.0000160703.75808.7d
  17. Pawlik TM, 2005, ANN SURG, V241, P722
  18. Pawlik TM, 2008, ONCOLOGIST, V13, P51, DOI 10.1634/theoncologist.2007-0142
  19. Rajaganeshan R, 2007, BRIT J CANCER, V96, P1112, DOI 10.1038/sj.bjc.6603677
  20. Robertson DJ, 2009, CANCER, V115, P752, DOI 10.1002/cncr.24081
  21. SCHEELE J, 1995, WORLD J SURG, V19, P59
  22. Simmonds PC, 2006, BRIT J CANCER, V94, P982, DOI 10.1038/sj.bjc.6603033
  23. Wong SL, 2010, J CLIN ONCOL, V28, P493, DOI 10.1200/JCO.2009.23.4450
  24. Yamaguchi J, 2002, WORLD J SURG, V26, P1122, DOI 10.1007/s00268-002-6267-y

Coleções
Artigos e Materiais de Revistas Científicas - FM/MGT
Artigos e Materiais de Revistas Científicas - FM/MPT
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/14
Artigos e Materiais de Revistas Científicas - LIM/35
Carregar mais