Increased expression of antimullerian hormone and its receptor in endometriosis

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art_CARRARELLI_Increased_expression_of_antimullerian_hormone_and_its_receptor_2014.PDF (1.77 MB)
Citações na Scopus
39
Tipo de produção
article
Data de publicação
2014
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER SCIENCE INC
Autores
CARRARELLI, Patrizia
ROCHA, Ana Luiza Lunardi
BELMONTE, Giuseppe
ZUPI, Errico
ARCURI, Felice
PIOMBONI, Paola
PETRAGLIA, Felice
Citação
FERTILITY AND STERILITY, v.101, n.5, p.1353-1358, 2014
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Objective: To evaluate antimullerian hormone (AMH) and AMH receptor II (AMHRII) mRNA and protein expression in endometrium and in ovarian or deep lesions of women with endometriosis. Design: Prospective study. Setting: University hospitals in Italy and Brazil. Patients: Patients with endometriosis (n = 55) and healthy women (n = 45). Interventions: Specimens of endometrium obtained by hysteroscopy from patients with endometriosis and from healthy control subjects; specimens of ovarian endometriosis (n = 29) or of deep endometriosis (n = 26) were collected by laparoscopy. Serum samples were collected in some endometriotic patients (n = 23) and healthy control subjects (n = 20). Main Outcome Measure(s): AMH and AMHRII mRNA levels were evaluated by quantitative reverse-transcription polymerase chain reaction and protein localization by immunohistochemistry. AMH levels in tissue homogenates and in serum were assessed by ELISA. Result(s): Endometrium from women with endometriosis showed higher AMH and AMHRII mRNA levels than control women, with no significant differences between proliferative and secretory phases. Specimens collected from ovarian or deep endometriosis showed the highest AMH and AMHRII mRNA expression. Immunolocalization study confirmed the high AMH and AMHRII protein expression in endometriotic lesions. No difference of serum AMH levels between the groups was found. Conclusion(s): The increased AMH and AMHRII mRNA and protein expression in endometrium and in endometriotic lesions suggests a possible involvement of AMH in endometriosis. (C) 2014 by American Society for Reproductive Medicine.
Palavras-chave
AMH, AMHRII, TGF-beta superfamily, endometriosis, ovarian and deep endometriosis
URI
https://observatorio.fm.usp.br/handle/OPI/7594
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MOG
Artigos e Materiais de Revistas Científicas - LIM/58