Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/805
Title: Histomorphometric analysis of the effects of creatine on rat myometrium
Authors: AMARAL, Vinicius Cestari DoSIMOES, Manuel De JesusMARCONDES, Rodrigo RodriguesCUBAS, Jairo Jose MatozinhoBARACAT, Edmund ChadaSOARES JR., Jose Maria
Citation: GYNECOLOGICAL ENDOCRINOLOGY, v.28, n.8, p.587-589, 2012
Abstract: Objective: To analyze the myometrial thickness of rats subjected to creatine (Cr) ingestion. Study design: A total of 14 rats was equally divided into the control group (ConGr) receiving 1 ml potable water and the creatine group (CrGr) subjected to the ingestion of 1.6 g/kg Cr diluted in 1 ml potable water. At the end of 8 weeks, the animals were anesthetized (xylazine and ketamine) and sacrificed, the uteri and ovaries stained with hematoxylin and eosin, the thickness of both the myometrium and the epithelium measured and the follicles counted. Results: Analysis revealed a significant increase in thickness of the myometrium in the CrGr (272.26 +/- 66.71 mu m) contrasted with that from the ConGr (160.76 +/- 35.65 mu m), CrGr > ConGr (p < 0001). Conclusion: Our data suggest that Cr changed myometrial morphology in rats by enhancing myometrial thickness, but its action mechanism in the smooth muscle is still unclear.
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Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/58

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