Coronary artery plaque burden and calcium scores in healthy men adhering to long-term wine drinking or alcohol abstinence
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Citações na Scopus
18
Tipo de produção
article
Data de publicação
2014
Título da Revista
ISSN da Revista
Título do Volume
Editora
ASSOC BRAS DIVULG CIENTIFICA
Autores
MOICHIDUKI, R. I.
GONSALVES, C. R. L.
Citação
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, v.47, n.8, p.697-705, 2014
Resumo
Observational studies suggest there are clinical benefits to moderate red wine (RW) consumption. However, the effects on coronary vasculature and overall lifestyle are unclear. We investigated whether a lifestyle of regular long-term RW consumption is associated with changes in coronary plaque burden, calcium score, carotid intima/media thickness, endothelial function, and metabolic variables, compared with alcohol abstinence. Healthy volunteers were evaluated by coronary computed tomography angiography (CTA) as well as carotid and brachial artery ultrasound. Nutritional status, psychological status, and metabolic variables were assessed. The study included 101 drinkers [aged 58.9 +/- 7.3 years (means +/- SD)], from wine brotherhoods, and 104 abstainers, from Anglican, Evangelical and Catholic churches both in the city of Sao Paulo, Brazil. No significant differences in demographics were noted. Lesion prevalence per patient assessed by coronary CTA and classified as absent (0), 1-25, 26-49, and >= 50% stenosis was similar between groups. When analyzed by individual arteries, i.e., left anterior descending, circumflex, and right coronary, prevalence was also not different. On the other hand, calcium scores were higher among drinkers than abstainers (144.4 +/- 362.2 vs 122.0 +/- 370.3; P < 0.01). However, drinkers reported less history of diabetes and exercised more. RW drinkers consumed 2127.9 +/- 387.7 kcal/day while abstainers consumed 1836.0 +/- 305.0 (P < 0.0001). HDL cholesterol was significantly higher among drinkers compared to abstainers (46.9 +/- 10.9 vs 39.5 +/- 9.0 mg/dL; P < 0.001), while fasting plasma glucose was lower (97.6 +/- 18.2 vs 118.4 +/- 29.6 mg/dL; P < 0.02). Liver enzymes were normal in both groups. In conclusion, long-term wine drinkers displayed a similar plaque burden but greater calcium score than abstainers, despite a more atherogenic diet, and the mechanisms for the increased calcium scores in the former remain speculative.
Palavras-chave
Atherosclerosis, Red wine, Lifestyle, Computer tomography angiography, Coronary calcium, Carotid plaques
Referências
- Baliunas DO, 2009, DIABETES CARE, V32, P2123, DOI 10.2337/dc09-0227
- Baur JA, 2006, NAT REV DRUG DISCOV, V5, P493, DOI 10.1038/nrd2060
- Baur JA, 2006, NATURE, V444, P337, DOI 10.1038/nature05354
- Brasnyo P, 2011, BRIT J NUTR, V106, P383, DOI 10.1017/S0007114511000316
- Brien SE, 2011, BRIT MED J, V342, DOI 10.1136/bmj.d636
- Bryson CL, 2006, J AM COLL CARDIOL, V48, P305, DOI 10.1016/j.jacc.2006.02.066
- Burke AP, 2001, HERZ, V26, P239, DOI 10.1007/PL00002026
- Buzzard M, 1988, NUTR EPIDEMIOLOGY, P50
- CAPRARA GV, 1992, J RES PERS, V26, P21, DOI 10.1016/0092-6566(92)90056-A
- Coimbra SR, 2005, BRAZ J MED BIOL RES, V38, P1339, DOI 10.1590/S0100-879X2005000900008
- da Luz PL, 1999, EXP MOL PATHOL, V65, P150, DOI 10.1016/S0014-4800(99)80004-5
- da Luz PL, 2012, ATHEROSCLEROSIS, V224, P136, DOI 10.1016/j.atherosclerosis.2012.06.007
- Dewey M, 2009, CIRCULATION, V120, P867, DOI 10.1161/CIRCULATIONAHA.109.859280
- Di Castelnuovo A, 2002, CIRCULATION, V105, P2836, DOI 10.1161/01.CIR.0000018653.19696.01
- Guarente L, 2011, NEW ENGL J MED, V364, P2235, DOI 10.1056/NEJMra1100831
- Kabacoff RI, 1997, J ANXIETY DISORD, V11, P33, DOI 10.1016/S0887-6185(96)00033-3
- Karatzi K, 2009, NUTR METAB CARDIOVAS, V19, P744, DOI 10.1016/j.numecd.2009.04.006
- Klatsky AL, 2003, AM J EPIDEMIOL, V158, P585, DOI 10.1093/aje/kwg184
- Lagouge M, 2006, CELL, V127, P1109, DOI 10.1016/j.cell.2006.11.013
- Lang RM, 2005, J AM SOC ECHOCARDIOG, V18, P1440, DOI 10.1016/j.echo.2005.10.005
- Ludwing MWB, 2012, ARQ BRAS PSICOL, V64, P31
- McClelland RL, 2008, AM J CLIN NUTR, V88, P1593, DOI 10.3945/ajcn.2008.26420
- Mintz GS, 1997, J AM COLL CARDIOL, V29, P268
- Motoyama S, 2009, J AM COLL CARDIOL, V54, P49, DOI 10.1016/j.jacc.2009.02.068
- Mukamal KJ, 2005, CIRCULATION, V112, P1406, DOI 10.1161/CIRCULATIONHA.105.537704
- Mukamal KJ, 2003, ARTERIOSCL THROM VAS, V23, P2252, DOI 10.1161/01.ATV.0000101183.58453.39
- Naumann VJ, 2004, INT PSYCHOGERIATR, V16, P159, DOI 10.1017/S1041610204000109
- Opie LH, 2007, EUR HEART J, V28, P1683, DOI 10.1093/eurheartj/ehm149
- Ramadori G, 2009, ENDOCRINOLOGY, V150, P5326, DOI 10.1210/en.2009-0528
- RENAUD S, 1992, LANCET, V339, P1523, DOI 10.1016/0140-6736(92)91277-F
- Ronksley PE, 2011, BRIT MED J, V342, DOI 10.1136/bmj.d671
- Scheuner MT, 2010, CIRC-CARDIOVASC GENE, V3, P97, DOI 10.1161/CIRCGENETICS.109.894527
- Tofferi JK, 2004, AM HEART J, V148, P803, DOI 10.1016/j.ajh.2004.05.023