Role of vascular endothelial growth factor polymorphisms (-2578C > A,-460 T > C,-1154G > A,+405G > C and+936C > T) in endometriosis: a case-control study with Brazilians

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art_PERINI_Role_of_vascular_endothelial_growth_factor_polymorphisms_2578C_2014.PDF (425.24 KB)
Citações na Scopus
30
Tipo de produção
article
Data de publicação
2014
DOI
Scopus
Web of Science
Título da Revista
ISSN da Revista
Título do Volume
Editora
BIOMED CENTRAL LTD
Autores
PERINI, Jamila Alessandra
CARDOSO, Jessica Vilarinho
BERARDO, Plinio Tostes
VIANNA-JORGE, Rosane
NASCIUTTI, Luiz Eurico
BELLODI-PRIVATO, Marta
MACHADO, Daniel Escorsim
Citação
BMC WOMENS HEALTH, v.14, article ID 117, 9p, 2014
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background: Endometriosis is regarded as a complex and heterogeneous disease in which genetic and eri'jironr>ental factors contribute to the phenotype. The Vascular Endothelial Growth Factor (VEGF) plays important roles in the pathogenesis of endometriosis. The present study was aimed at investigating the contribution of VEGF polymorphisms as risk factors for the development of endometriosis. This is the first study to evaluate the combined influence of the five roost common VEGF polyroorphisms. Methods: This study was conducted at two hospitals from the Brazilian public health system, and comprised 294 vvomen submitted to laparoscopic or laparotomy surgery: 182 patients had a histologically confirmed diagnosis of endometriosis (cases), whereas 112 had no evidence of the disease (controls). The VEGF polymorphisms were determined by TagMan cal time polymerase chain reaction. The odds ratio (OR) with their 957o confidence intervals (Cl) were calculated using an unconditional logistic regression model. Results: Endometriosis patients and controls did not differ regarding age distribution, whereas the body mass index was significantly lower in enciometriosis patients, when compared with controls (23.1 3.9 versus 27.3 5.9, P <0001). The evaluation of gynecological symptoms, including dysmenorrhea, non cyclic chronic pelvic pain, dyspareunia and infertility, indicates significantly higher prevalences among endometriosis cases. The variant allele -1154A was significantly associated with endometriosis, either considering all cases (OR: 1.90, 95% Cl: 1.23 2.97), deep infiltrating endometriosis (DIE) (OR: 1.83, 95% Cl: 1.16-2.90) or moderate and severe endometriosis (stages Ill l5 (OR: 1.97, 95% Cl: 1.21-3.19). No significant differences were found in allele or genotype distributions of the 2578C > A, 460 T> C, +4070> C and +9,36C > T polymorphisms between endometriosis cases and controls. A total of six haplotypes were inferred derived from four polymorphisms (-2578C > A, 460 T> C, 1 1540 > A and +4050> C). There was a protective association between CCGG haplotype and endometriosis, either considering all cases (OR: 0.36, 95% Cl: 0.15-0.86), DIE (OR: 0.37 95% Cl: 0.15 0.90) or stages Ill IV (OR: 0.35 953 Cl: 0.13 ---- 0.95). Conclusions: The present results indicate a positive association between VEGF '11540 > A and the risk of developing endometriosis, whereas the CCGG haplotype may be protective against the development of disease.
Palavras-chave
Endometriosis, Vascular endothelial growth factor, Rolymorphisms, Brazilian population
URI
https://observatorio.fm.usp.br/handle/OPI/8527
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MOG
Artigos e Materiais de Revistas Científicas - LIM/58