Outdoor Particulate Matter Exposure and Lung Cancer: A Systematic Review and Meta-Analysis

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art_HAMRA_Outdoor_Particulate_Matter_Exposure_and_Lung_Cancer_A_2014.PDF (263.23 KB)
Citações na Scopus
746
Tipo de produção
article
Data de publicação
2014
DOI
Scopus
Web of Science
Título da Revista
ISSN da Revista
Título do Volume
Editora
US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
Autores
HAMRA, Ghassan B.
GUHA, Neela
COHEN, Aaron
LADEN, Francine
RAASCHOU-NIELSEN, Ole
SAMET, Jonathan M.
VINEIS, Paolo
FORASTIERE, Francesco
YORIFUJI, Takashi
Citação
ENVIRONMENTAL HEALTH PERSPECTIVES, v.122, n.9, p.906-911, 2014
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
BACKGROUND: Particulate matter (PM) in outdoor air pollution was recently designated a Group I carcinogen by the International Agency for Research on Cancer (IARC). This determination was based on the evidence regarding the relationship of PM2.5 and PM10 to lung cancer risk; however, the IARC evaluation did not include a quantitative summary of the evidence. OBJECTIVE: Our goal was to provide a systematic review and quantitative summary of the evidence regarding the relationship between PM and lung cancer. Methods: We conducted meta-analyses of studies examining the relationship of exposure to PM2.5 and PM10 with lung cancer incidence and mortality. In total, 18 studies met our inclusion criteria and provided the information necessary to estimate the change in lung cancer risk per 10-mu g/m(3) increase in exposure to PM. We used random-effects analyses to allow between-study variability to contribute to meta-estimates. RESULTS: The meta-relative risk for lung cancer associated with PM2.5 was 1.09 (95% CI: 1.04, 1.14). The meta-relative risk of lung cancer associated with PM10 was similar, but less precise: 1.08 (95% CI: 1.00, 1.17). Estimates were robust to restriction to studies that considered potential confounders, as well as subanalyses by exposure assessment method. Analyses by smoking status showed that lung cancer risk associated with PM2.5 was greatest for former smokers [1.44 (95% CI: 1.04, 1.22)], followed by never-smokers [1.18 (95% CI: 1.00, 1.39)], and then current smokers [1.06 (95% CI: 0.97, 1.15)]. In addition, meta-estimates for adenocarcinoma associated with PM2.5 and PM10 were 1.40 (95% CI: 1.07, 1.83) and 1.29 (95% CI: 1.02, 1.63), respectively. CONCLUSION: The results of these analyses, and the decision of the IARC Working Group to classify PM and outdoor air pollution as carcinogenic (Group 1), further justify efforts to reduce exposures to air pollutants that can arise from many sources.
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URI
https://observatorio.fm.usp.br/handle/OPI/8620
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MPT
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/05
Artigos e Materiais de Revistas Científicas - ODS/03