OSA Is Common and Independently Associated With Hypertension and Increased Arterial Stiffness in Consecutive Perimenopausal Women

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art_PEDROSA_OSA_Is_Common_and_Independently_Associated_With_Hypertension_2014.PDF (578.3 KB)
Citações na Scopus
36
Tipo de produção
article
Data de publicação
2014
DOI
Scopus
Web of Science
Título da Revista
ISSN da Revista
Título do Volume
Editora
AMER COLL CHEST PHYSICIANS
Autores
PEDROSA, Rodrigo P.
BARROS, Isly M. L.
MEDEIROS, Ana Kelley L.
CARVALHO, Liana L.
LUSTOSA, Thais C.
CARVALHO, Martinha M. B.
FERREIRA, Moacir N. L.
Citação
CHEST, v.146, n.1, p.66-72, 2014
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
BACKGROUND: Perimenopause is associated with increased cardiovascular risk. OSA is an emerging risk factor for cardiovascular disease, particularly among men, but the independent contribution of OSA to cardiovascular risk in climacteric women is not clear. METHODS: We evaluated 277 consecutive women (age, 56 [52-61] years; BMI, 28 [25-32] kg/m(2)) without manifest cardiovascular disease (heart failure, coronary disease, or stroke). All women underwent 24-h ambulatory BP monitoring, arterial stiffness evaluation (pulse wave velocity), and portable sleep study. RESULTS: OSA (apnea-hypopnea index >= 5 events/h) and moderate to severe OSA (apnea-hypopnea index >= 15 events/h) were diagnosed in 111(40.1%) and 31 (11.1%) women, respectively. None of the participants had received a previous diagnosis of OSA. Women with moderate to severe OSA vs those without OSA had a higher prevalence of hypertension, were prescribed more medications for hypertension, had higher awake BP (systolic, 133 [125-142] vs 126 [119-134] mm Hg [ P < .01]; diastolic, 82 [78-88] vs 79 [74-85] mm Hg [P = .07]), higher nocturnal BP (systolic, 125 [118-135] vs 115 [109-124] mm Hg [P < .01]; diastolic, 73 [69-79] vs 69 [62-75] mm Hg [P < .01]), and more arterial stiffness (pulse wave velocity, 11.5 [10.1-12.3] m/s vs 9.5 [8.6-10.8] m/s, P < .001). Oxygen desaturation index during the night was independently associated with 24-h arterial BP and arterial stiffness (per five-unit increase in oxygen desaturation index, beta = 1.30 [95% CI, 0.02-2.54; P = .04] vs 0.22 [95% CI, 0.03-0.40; P = .02] in women with vs without OSA, respectively). CONCLUSIONS: OSA is common, underdiagnosed, and independently associated with high BP and increased arterial stiffness in perimenopausal women.
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URI
https://observatorio.fm.usp.br/handle/OPI/8674
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/09
Artigos e Materiais de Revistas Científicas - ODS/03