S100B is downregulated in the nuclear proteome of schizophrenia corpus callosum

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art_STEINER_S100B_is_downregulated_in_the_nuclear_proteome_of_2014.PDF (536.85 KB)
Citações na Scopus
19
Tipo de produção
article
Data de publicação
2014
DOI
Scopus
Web of Science
Título da Revista
ISSN da Revista
Título do Volume
Editora
SPRINGER HEIDELBERG
Autores
STEINER, Johann
SCHROETER, Matthias L.
BOGERTS, Bernhard
FALKAI, Peter
TURCK, Christoph W.
Citação
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, v.264, n.4, p.311-316, 2014
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Here we report the downregulation of S100B in the nuclear proteome of the corpus callosum from nine schizophrenia patients compared to seven mentally healthy controls. Our data have been obtained primarily by mass spectrometry and later confirmed by Western blot. This is an intriguing finding coming from a brain region which is essentially composed by white matter, considering the potential role of S100B in the control of oligodendrocyte maturation. This data reinforce the importance of oligodendrocytes in schizophrenia, shedding more light to its pathobiology.
Palavras-chave
S100B, Corpus callosum, White matter, Oligodendrocytes, Proteomics, Mass spectrometry
URI
https://observatorio.fm.usp.br/handle/OPI/8797
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Coleções
Artigos e Materiais de Revistas Científicas - LIM/27