High genital prevalence of cutaneous human papillomavirus DNA on male genital skin: the HPV Infection in Men Study

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Arquivos
art_SICHERO_High_genital_prevalence_of_cutaneous_human_papillomavirus_DNA_2014.PDF (263.87 KB)
Citações na Scopus
21
Tipo de produção
article
Data de publicação
2014
DOI
Scopus
Web of Science
Título da Revista
ISSN da Revista
Título do Volume
Editora
BIOMED CENTRAL LTD
Autores
CAMPBELL, Christine M. Pierce
FULP, William
GALAN, Lenice
SILVA, Roberto C.
LAZCANO-PONCE, Eduardo
GIULIANO, Anna R.
Citação
BMC INFECTIOUS DISEASES, v.14, article ID 677, 9p, 2014
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background: The genital skin of males hosts a diversity of HPV genotypes and uncharacterized HPV genotypes. Previously we demonstrated that a specific viral genotype was not identified in 14% of all genital specimens (i.e., HPV unclassified specimens) using the Roche Linear Array method. Our goal was to identify and assess the prevalence of individual HPV types among genital HPV unclassified specimens collected in the HIM Study population, at enrollment, and examine associations with socio-demographic and behavioral characteristics. Methods: Genital skin specimens of men that were considered unclassified (HPV PCR positive, no genotype specified) at enrollment were typed by sequencing amplified PGMY09/11 products or cloning of PGMY/GP+ nested amplicons followed by sequencing. PGMY/GP+ negative specimens were further analyzed using FAP primers. HPV type classification was conducted through comparisons with sequences in the GenBank database. Results: Readable nucleotide sequences were generated for the majority of previously unclassified specimens (66%), including both characterized (77%) and yet uncharacterized (23%) HPV types. Of the characterized HPV types, most (73%) were Beta [beta]-HPVs, primarily from beta-1 and beta-2 species, followed by Alpha [alpha]-HPVs (20%). Smokers (current and former) were significantly more likely to have an alpha-HPV infection, compared with any other genus; no other factors were associated with specific HPV genera or specific beta-HPV species. Conclusions: Male genital skin harbor a large number of beta-HPV types. Knowledge concerning the prevalence of the diverse HPV types in the men genital is important to better understand the transmission of these viruses.
Palavras-chave
Human papillomavirus, Cutaneous HPV, Males, HIM Study, Prevalence, Prospective study
URI
https://observatorio.fm.usp.br/handle/OPI/9325
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MDR
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - LIM/24