The effects of zoledronic acid and dexamethasone on osseointegration of endosseous implants: histological and histomorphometrical evaluation in rats

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art_OLIVEIRA_The_effects_of_zoledronic_acid_and_dexamethasone_on_2015.PDF (267.19 KB)
Citações na Scopus
15
Tipo de produção
article
Data de publicação
2015
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
WILEY-BLACKWELL
Autores
OLIVEIRA, Marcio A. de
ASAHI, Denise A.
LIMA, Luiz Antonio P. A.
GLICK, Michael
GALLOTTINI, Marina
Citação
CLINICAL ORAL IMPLANTS RESEARCH, v.26, n.4, p.e17-e21, 2015
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
BackgroundBisphosphonates are a widely used class of drugs that prevent bone loss. Several side effects related to bisphosphonate therapy have been reported, including osteonecrosis of the jaws associated with invasive dental procedures and implants placement. ObjectivesTo evaluate the influence of intravenous nitrogen-containing BPs in combination with or without dexamethasone on osseointegration of titanium implants placed in an animal model. MethodsTwenty-seven male Wistar rats were divided into three groups: group 1 was treated solely with zoledronic acid, group 2 was treated with zoledronic acid and dexamethasone, and group 3 did only receive saline solution injections. Two endosseous implants were placed in each tibia, and three animals from each group were sacrificed at postoperative times of seven, 14, and 28days. Non-decalcified sections were observed with light microscopy for histological and histomorphometrical analyses. ResultsHistomorphometrical analysis using the animals and the implants as unit of measurement revealed no statistically significant difference regarding bone-implant contact and bone density among the three groups. Histological observation revealed that zoledronic acid-treated animals in combination with or without dexamethasone showed expressive less bone remodeling activity at 14 and 28days after implants placement, compared with control specimens. ConclusionsThe studied bisphosphonate regimens did not interfere with the osseointegration of the implants, cortical, or medular bone deposition, but a possible lack of bone remodeling of the original cortical bone may affect long-term osseointegration.
Palavras-chave
animal model, bisphosphonates, endosseous implants
URI
https://observatorio.fm.usp.br/handle/OPI/9510
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Coleções
Artigos e Materiais de Revistas Científicas - FM/Outros