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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | LAKRYC, Eli Marcelo | - |
dc.contributor.author | MACHADO, Rogerio Bonassi | - |
dc.contributor.author | SOARES JR., Jose Maria | - |
dc.contributor.author | BARACAT, Edmund Chada | - |
dc.date.accessioned | 2015-08-14T15:38:59Z | - |
dc.date.available | 2015-08-14T15:38:59Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | CLINICS, v.70, n.2, p.107-113, 2015 | - |
dc.identifier.issn | 1807-5932 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/9824 | - |
dc.description.abstract | OBJECTIVE: To evaluate the influence of estrogen therapy and estrogen-progestin therapy on homocysteine and C-reactive protein levels in postmenopausal women. METHODS: In total, 99 postmenopausal women were included in this double-blind, randomized clinical trial and divided into three groups: Group A used estrogen therapy alone (2.0 mg of 17 beta-estradiol), Group B received estrogen-progestin therapy (2.0 mg of 17 beta-estradiol +1.0 mg of norethisterone acetate) and Group C received a placebo (control). The length of treatment was six months. Serum measurements of homocysteine and C-reactive protein were carried out prior to the onset of treatment and following six months of therapy. RESULTS: After six months of treatment, there was a 20.7% reduction in homocysteine levels and a 100.5% increase in C-reactive protein levels in the group of women who used estrogen therapy. With respect to the estrogen-progestin group, there was a 12.2% decrease in homocysteine levels and a 93.5% increase in C-reactive protein levels. CONCLUSION: Our data suggested that hormone therapy (unopposed estrogen or estrogen associated with progestin) may have a positive influence on decreasing cardiovascular risk due to a significant reduction in homocysteine levels. | - |
dc.language.iso | eng | - |
dc.publisher | HOSPITAL CLINICAS, UNIV SAO PAULO | - |
dc.relation.ispartof | Clinics | - |
dc.rights | openAccess | - |
dc.subject | Estrogen-Progestin Therapy | - |
dc.subject | Estrogen | - |
dc.subject | Homocysteine | - |
dc.subject | CRP | - |
dc.subject | Cardiovascular Risk | - |
dc.subject.other | c-reactive protein | - |
dc.subject.other | estrogen plus progestin | - |
dc.subject.other | replacement therapy | - |
dc.subject.other | plasma homocysteine | - |
dc.subject.other | cardiovascular-disease | - |
dc.subject.other | myocardial-infarction | - |
dc.subject.other | serum homocysteine | - |
dc.subject.other | clinical-trial | - |
dc.subject.other | heart-disease | - |
dc.subject.other | risk-factor | - |
dc.title | What is the influence of hormone therapy on homocysteine and crp levels in postmenopausal women? | - |
dc.type | article | - |
dc.rights.holder | Copyright HOSPITAL CLINICAS, UNIV SAO PAULO | - |
dc.identifier.doi | 10.6061/clinics/2015(02)07 | - |
dc.identifier.pmid | 25789519 | - |
dc.subject.wos | Medicine, General & Internal | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.author.external | LAKRYC, Eli Marcelo:Univ Fed Sao Paulo, Escola Paulista Med, Dept Gynecol, Sao Paulo, SP, Brazil | - |
hcfmusp.author.external | MACHADO, Rogerio Bonassi:Univ Fed Sao Paulo, Escola Paulista Med, Dept Gynecol, Sao Paulo, SP, Brazil | - |
hcfmusp.description.beginpage | 107 | - |
hcfmusp.description.endpage | 113 | - |
hcfmusp.description.issue | 2 | - |
hcfmusp.description.volume | 70 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | 2-s2.0-84924955113 | - |
hcfmusp.origem.id | WOS:000351602700007 | - |
hcfmusp.origem.id | SCIELO:S1807-59322015000200107 | - |
hcfmusp.publisher.city | SAO PAULO | - |
hcfmusp.publisher.country | BRAZIL | - |
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dc.description.index | MEDLINE | - |
dc.identifier.eissn | 1980-5322 | - |
hcfmusp.citation.scopus | 12 | - |
hcfmusp.scopus.lastupdate | 2024-03-29 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MOG Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/58 |
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