LIM/56 - Laboratório de Investigação em Dermatologia e Imunodeficiências

URI Permanente desta comunidade

https://observatorio.fm.usp.br/handle/OPI/3818
O Laboratório de Investigação em Dermatologia e Imunodeficiências é ligado ao Departamento de Dermatologia da Faculdade de Medicina da Universidade de São Paulo (FMUSP).

Linhas de pesquisa: dermatoses infecciosas e parasitárias; imunodermatologia; imunologia viral; imunomodulação experimental; imunopatologia da infecção pelo HIV; imunopatologia das imunodeficiências primárias; imunopatologia das imunodeficiências secundárias, infecciosas ou metabólicas; imunopatologia das infecções primárias; imunorregulação; retrovirose humana.

Site oficial: http://limhc.fm.usp.br/portal/lim56-laboratorio-de-investigacao-em-dermatologia-e-imunodeficiencias/

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article 0 Citação(ões) na Scopus
Data-driven, cross-disciplinary collaboration: lessons learned at the largest academic health center in Latin America during the COVID-19 pandemic
(2024) RITTO, Ana Paula; ARAUJO, Adriana Ladeira de; CARVALHO, Carlos Roberto Ribeiro de; SOUZA, Heraldo Possolo De; FAVARETTO, Patricia Manga e Silva; SABOYA, Vivian Renata Boldrim; GARCIA, Michelle Louvaes; KULIKOWSKI, Leslie Domenici; KALLAS, Esper Georges; PEREIRA, Antonio Jose Rodrigues; COBELLO JUNIOR, Vilson; SILVA, Katia Regina; ABDALLA, Eidi Raquel Franco; SEGURADO, Aluisio Augusto Cotrim; SABINO, Ester Cerdeira; RIBEIRO JUNIOR, Ulysses; FRANCISCO, Rossana Pulcineli Vieira; MIETHKE-MORAIS, Anna; LEVIN, Anna Sara Shafferman; SAWAMURA, Marcio Valente Yamada; FERREIRA, Juliana Carvalho; SILVA, Clovis Artur; MAUAD, Thais; GOUVEIA, Nelson da Cruz; LETAIF, Leila Suemi Harima; BEGO, Marco Antonio; BATTISTELLA, Linamara Rizzo; DUARTE, Alberto Jose da Silva; SEELAENDER, Marilia Cerqueira Leite; MARCHINI, Julio; FORLENZA, Orestes Vicente; ROCHA, Vanderson Geraldo; MENDES-CORREA, Maria Cassia; COSTA, Silvia Figueiredo; CERRI, Giovanni Guido; BONFA, Eloisa Silva Dutra de Oliveira; CHAMMAS, Roger; BARROS FILHO, Tarcisio Eloy Pessoa de; BUSATTO FILHO, Geraldo
Introduction The COVID-19 pandemic has prompted global research efforts to reduce infection impact, highlighting the potential of cross-disciplinary collaboration to enhance research quality and efficiency.Methods At the FMUSP-HC academic health system, we implemented innovative flow management routines for collecting, organizing and analyzing demographic data, COVID-related data and biological materials from over 4,500 patients with confirmed SARS-CoV-2 infection hospitalized from 2020 to 2022. This strategy was mainly planned in three areas: organizing a database with data from the hospitalizations; setting-up a multidisciplinary taskforce to conduct follow-up assessments after discharge; and organizing a biobank. Additionally, a COVID-19 curated collection was created within the institutional digital library of academic papers to map the research output.Results Over the course of the experience, the possible benefits and challenges of this type of research support approach were identified and discussed, leading to a set of recommended strategies to enhance collaboration within the research institution. Demographic and clinical data from COVID-19 hospitalizations were compiled in a database including adults and a minority of children and adolescents with laboratory confirmed COVID-19, covering 2020-2022, with approximately 350 fields per patient. To date, this database has been used in 16 published studies. Additionally, we assessed 700 adults 6 to 11 months after hospitalization through comprehensive, multidisciplinary in-person evaluations; this database, comprising around 2000 fields per subject, was used in 15 publications. Furthermore, thousands of blood samples collected during the acute phase and follow-up assessments remain stored for future investigations. To date, more than 3,700 aliquots have been used in ongoing research investigating various aspects of COVID-19. Lastly, the mapping of the overall research output revealed that between 2020 and 2022 our academic system produced 1,394 scientific articles on COVID-19.Discussion Research is a crucial component of an effective epidemic response, and the preparation process should include a well-defined plan for organizing and sharing resources. The initiatives described in the present paper were successful in our aim to foster large-scale research in our institution. Although a single model may not be appropriate for all contexts, cross-disciplinary collaboration and open data sharing should make health research systems more efficient to generate the best evidence.
article 0 Citação(ões) na Scopus
Areata-Like Lupus as a Clinical Manifestation of Cutaneous Lupus Erythematosus
(2022) MORAIS, K. L.; SECCHIN, P.; ANZAI, A.; VERUSSA, M. J. M. C.; MUNCK, A.; FECHINE, C. O. C.; VALENTE, N. Y. S.; ROMITI, R.
Introduction: Lupus erythematosus (LE) is a chronic autoimmune disease that frequently causes hair loss and scalp lesions. Hair loss can be scarring and nonscarring, diffuse, or patchy. The nonscarring patchy alopecia is usually related to systemic LE (SLE) and may simulate alopecia areata (AA), reason why it is named areata-like lupus. Our case was diagnosed with areata-like lupus but did not meet criteria for SLE. Case Report: A 63-year-old woman presented with irregular nonscarring patchy alopecia in the temporal and frontoparietal scalp. Trichoscopy showed exclamation mark hairs, vellus hairs, and sparse yellow dots. Histology revealed epidermal vacuolar interface dermatitis, lymphohistiocytic infiltrate around the bulbs of anagen follicles, and eccrine glands. Direct immunofluorescence showed deposits of C3, IgA, and IgG in the basement membrane zone. Discussion: Patients with cutaneous LE can also manifest as nonscarring patchy alopecia that is clinically similar to AA, despite the absence of systemic manifestations. Areata-like lupus is secondary to the lupus autoimmune infiltrate that affects the skin including the hair follicles. Trichoscopy, histology, and direct immunofluorescence are important to differentiate this form of alopecia from AA, which is believed to have a higher incidence in lupus patients.
article 0 Citação(ões) na Scopus
article 0 Citação(ões) na Scopus
Are dogs not susceptible to retroviral infections?
(2023) CASSEB, J.; CAMPOS, J. H.; LOPES, L. R.
Retroviruses have been proven to cause infections and diseases in a series of mammalian hosts but not in dogs. Then, this letter discussed the dog susceptibility to retrovirus infection, encompassing arguments to understand why dogs may have not been infected by retroviruses thus far. The potential resistance of retrovirus in dogs enables this provocative short communication to discuss this question, looking at some evolutive aspects. The lineage of canids has shown, throughout its evolutionary history, a smaller accumulation of retroviruses in canid genomes, classified as endogenous retroviruses. In this context, the genomes of canids seem to offer obstacles, which have been evolutionarily conserved, in the face of retroviral infection.
article 0 Citação(ões) na Scopus
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Rapid HIV progression in patients with increased prevalence of unstable HLA-C variants
(2023) RUGGIERO, Alessandra; STEFANI, Chiara; SANGALLI, Antonella; LOCATELLI, Elena; FEDERICO, Tania; MALERBA, Giovanni; ROMANELLI, Maria Grazia; ARGANARAZ, Gustavo Adolfo; SILVA, Bosco Christiano Maciel Da; SILVA, Alberto Jose Duarte Da; CASSEB, Jorge; ARGANARAZ, Enrique Roberto; ZIPETO, Donato
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Impact of climate change on atopic dermatitis: A systematic search and review by the International Eczema Council
(2023) WANG, S.; STEFANOVIC, N.; ORFALI, R. L.; AOKI, V.; BROWN, S.; DHAR, S.; EICHENFIELD, L. F.; FLOHR, C.; HA, A.; MORA, C.; MURASE, J.; ROSENBACH, M.; THYSSEN, J.; WEI, M. L.; IRVINE, A. D.; ABUABARA, K.
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A LARGE LANGUAGE MODEL ARTIFICIAL INTELLIGENCE FOR PATIENT QUERIES IN ATOPIC DERMATITIS
(2023) SULEJMANI, Pranvera; NEGRIS, Olivia; AOKI, Valeria; CHU, Chia-Yu; EICHENFIELD, Lawrence; MISERY, Laurent; MOSCA, Ana; ORFALI, Raquel Leao; AROMAN, Marketa Saint; STALDER, Jean-Francois; TRZECIAK, Magdalena; WOLLENBERG, Andreas; LIO, Peter
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The imbalance between subpopulations of regulatory T (TREG) Cells at different stages of chronic obstructive pulmonary disease (COPD)
(2023) ALVES, Luan Henrique Vasconcelos; A, Juliana Tiyaki Ito; OLIVEIRA, Luana Mendonca De; TIBERIO, Iolanda Lopes Calvo; STELMACH, Rafael; SATO, Maria Notomi; ALMEIDA, Francine Maria; LOPES, Fernanda Degobbi Tenorio Quirino dos Santos
article 0 Citação(ões) na Scopus
Sensitive Scalp and Trichodynia: Epidemiology, Etiopathogenesis, Diagnosis, and Management
(2023) SOUZA, Emilly Neves; ANZAI, Alessandra; FECHINE, Carolina Oliveira Costa; VALENTE, Neusa Yuriko Sakai; ROMITI, Ricardo
Sensitive scalp (SSc) is considered a sensitive skin on the scalp, with its particularities. Although it is not rare in the dermatological practice and the term is commonly present in personal care products, this entity is poorly investigated in the medical literature. The etiopathogenesis is still uncertain, and the sensitivity may be associated with hair loss. Clinical manifestations are subjective symptoms of pruritus, burning, pain, pricking, and/or trichodynia, often with scalp erythema. SSc can be triggered by several factors (endogenous or exogenous). The diagnosis is guided by the anamnesis, and there are still no specific trichoscopic features. Trigeminal trophic syndrome and postherpetic neuralgia are the main differential diagnosis to be considered. We organized the therapeutical approach in three steps: scalp care, topical and systemic treatment.