MARIO CICERO FALCAO
Projetos de Pesquisa
Unidades Organizacionais
Instituto da Criança, Hospital das Clínicas, Faculdade de Medicina - Médico
18 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 18
- Omphalocele and biliary atresia: chance or causality. A case report(2022) ROSA, Julia Amim; PINTO, Ana Maria Rossignolli; BIGIO, Juliana Zoboli Del; LIMA, Larissa Barbosa; SILVA, Marcos Marques da; MANO, Rafaela Braga Cabrera; FALCAO, Mario CiceroTo relate omphalocele and biliary atresia and investigate possible embryological correlations that justify the simultaneous occurrence. A female preterm newborn diagnosed as omphalocele; cesarean delivery, weight 2,500g, 46 XX karyotype. Initially, the newborn remained fasting and on parenteral nutrition, and enteral diet was introduced later, with good acceptance. On the 12th day of life, the newborn presented direct hyperbilirubinemia, increased levels of liver enzymes and fecal acholia, with a presumptive diagnosis of biliary atresia. However, the ultrasound was inconclusive, due to anatomical changes resulting from omphalocele. A surgical approach was chosen on the 37th day of life aiming to confirm diagnosis of biliary atresia and to repair omphalocele. During the surgical procedure, structural alterations compatible with biliary atresia were observed, later confirmed by pathological examination; a hepatoportoenterostomy was performed and the omphalocele was corrected. She evolved well in the postoperative period, with a decrease in direct bilirubin and liver enzymes, as well as resolution of fecal acholia, and was discharged in good clinical condition. This is a bizarre and extremely rare association, but the prognosis may be good when an early diagnosis is made and surgery performed, besides support and clinical management to prevent complications in the perioperative period. Although the pathogenesis of the diseases has not been fully defined yet, there is, to date, no direct relation between them. The association between omphalocele and biliary atresia is extremely uncommon, with only two published cases.
- Use of sildenafil in late postoperative period of congenital diaphragmatic hernia(2021) FALCAO, Mario Cicero; TELLES, Ana Paula Andrade; AGUIAR, Marcela Ludwig Macedo da; BIGIO, Juliana Zoboli Del
- Prevalence of abdominal obesity in adolescents: a systematic review(2011) MORAES, A. C. F. de; FADONI, R. P.; RICARDI, L. M.; SOUZA, T. C.; ROSANELI, C. F.; NAKASHIMA, A. T. A.; FALCAO, M. C.The objectives of this study were to (i) review extant literature on the prevalence of abdominal obesity (AO) in adolescents of both sex (10-19 years old); (ii) analyse the cut-off points used for the diagnosis of AO and (iii) compare its prevalence between developed and developing countries. The search was carried out using online databases (MEDLINE, Web of Science, EMBASE, SPORTDiscus, SCIELO and BioMed Central), references cited by retrieved articles and by contact with the authors, considering articles published from the establishment of the databanks until 19 October 2009. Only original articles and those using waist circumference in the diagnosis were considered. Twenty-nine studies met the inclusion criteria. Fourteen of these studies were performed in developed countries. The prevalence of AO varied from 3.8% to 51.7% in adolescents from developing countries. The range of results was smaller among developed countries; with values from 8.7% to 33.2%. Eighteen different cut-off points were used. It was concluded the AO prevalence is high among adolescents, but is not clear what sex has a higher proportion and it is greater in adolescents from developing countries; however, there is no consensus in the literature about the criteria to be used.
- Effects of human milk fortifier with iron on the bacteriostatic properties of breast milk(2013) CAMPOS, Leticia Fuganti; REPKA, Joao Carlos Domingues; FALCAO, Mario CiceroObjective: To compare bacterial growth in pure colostrum versus colostrum with human milk fortifier (HMF) containing iron. Methods: The growth of Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa in 78 samples of pure colostrum or colostrum with added iron-containing HMF was compared. For qualitative analysis, filter paper discs were immersed in samples from each group and incubated for 48 hours with 10(1) colony forming units (CFUs)/mL of each strain. For quantitative assessment, 1 mL of each strain containing 10(7) CFUs/mL was homogenized with 1 mL of either colostrum or colostrum with human milk fortifier, seeded into a Petri dish, and incubated at 37 degrees C. Twenty-four hours later, the number of CFUs was counted. Results: The qualitative analysis showed no difference in bacterial growth. In the quantitative evaluation, E. coli growth in the control group was 29.4 +/- 9.7 x 10(6) CFU/mL, while in the HMF group it was 31.2 +/- 10.8 x 10(6) CFU/mL. The difference between the average growth was 1.9 +/- 4.9 x 10(6) CFU/mL (p = 0.001). There were no differences in S. aureus and P aeruginosa growth. Conclusion: Addition of iron at this concentration reduces breast milk bacteriostatic action against E. coli.
- Severe irritability in a critically ill preterm infant: a case of delirium at the neonatal intensive care unit(2023) MORAES, Lucas Hirano Arruda; MAROPO, Vanessa Lisbethe Bezerra; ZOBOLI, Ivete; FALCÃO, Mário Cícero; CARVALHO, Werther Brunow deAbstract Delirium is a common disorder in intensive care units, being associated with greater morbidity and mortality. However, in neonatal intensive care units, delirium is rarely diagnosed, due to the low familiarity of the neonatologist with the subject and the difficulties in the applicability of diagnostic questionnaires. This case report aimed to assess the presence of this disorder in this group of patients and identify the difficulties encountered in the diagnosis and treatment. We report the case of a premature newborn with necrotizing enterocolitis during hospitalization and underwent three surgical approaches. The newborn exhibited intense irritability, having received high doses of fentanyl, dexmedetomidine, clonidine, ketamine, phenytoin, and methadone, without the control of the symptoms. A diagnosis of delirium was then made and treatment with quetiapine was started, with a complete reversal of the symptoms. This is the first case reported in Brazil and the first describing the withdrawal of the quetiapine.
- Avaliação do desenvolvimento motor e do efeito da intervenção fisioterapêutica em recém-nascidos cirúrgicos em Unidade de Terapia Intensiva Neonatal(2022) SHIMIZU, Glaucia Yuri; CECCON, Maria Esther Jurfest Rivero; PAULA, Lúcia Cândida Soares de; FALCÃO, Mário Cícero; TANNURI, Uenis; CARVALHO, Werther Brunow deABSTRACT This study aimed to verify the applicability of the Test of Infant Motor Performance (TIMP) in surgical neonates as a tool for evaluating motor performance and to evaluate the benefit of physical therapy. Surgical neonates, divided into group without physical therapy (n=38) and group with motor physical therapy (n=38), were evaluated by TIMP and reasssment two weeks later. The physical therapy group performed standardized exercises for motor sensory stimulation once a day, whereas the other group received the usual care from the Neonatal Intensive Care Unit. The predominant surgical diagnosis in both groups was gastroschisis, followed by congenital diaphragmatic hernia. In the initial evaluation, motor performance was equal between the groups, classified as “below average” for age, with z-score=−1.28 (p=0.992). In the reassessment, the physical therapy group presented better scores (p<0.001) and a higher difference in z-score (p<0.001), higher percentage of neonates classified as “within average” (44% in the physical therapy group and 2.6% in the no physical therapy group), as well as a higher weight gain percentage (p=0.038). We found a worsening of motor performance in 10.5% of the no physical therapy group (p<0.001) in the reassment. Motor performance improved in 81.6% of the physical therapy group and in only 13.2% of the no physical therapy group individuals (p<0.001). Conclusion: TIMP was safely and effectively applied to newborns; notably, the test must be performed by professionals experienced in care of neonates. Motor intervention was beneficial, significantly improving motor performance, and if applied early, it may adequate the motor development of these neonates, even before hospital discharge.
- Factors associated with medicine use and self medication are different in adolescents(2011) MORAES, Augusto Cesar Ferreira de; DELAPORTE, Thayla Regina Mortean; MOLENA-FERNANDES, Carlos Alexandre; FALCAO, Mario CiceroOBJECTIVE: To estimate the prevalence of medicine use among high school students (14-18 years old) living in an urban area in Southern Brazil and the proportion who self-medicate and to explore the association between medicine use and demographic, socioeconomic, and behavioral variables. METHODS: A school-based survey was conducted among high school students in the city of Maringa/PR, Brazil in 2007. The sample students were selected through two-stage random sampling. The sample included 991 students (54.5% females) from eight public and four private high schools. The data were collected using a structured questionnaire. Only medications used within the 15 days preceding data collection were considered. The independent variables studied were sex, age, socioeconomic status, living with parents, employment status, smoking habits, and alcohol use. RESULTS: The prevalence of medicine use among the adolescents was 55.8% (females = 64.3%, males = 45.7%, p<0.001) and 52.6% of this use represented self medication (females = 51.0%, males = 56.8, p = 0.21). The factors associated with medicine use were age, employment, and smoking, while the factors associated with self medication were male gender and employment. Chronic users did not tend to self-medicate. CONCLUSION: The data from this study demonstrate a high prevalence of medicine use and self medication; however, the variables associated with medicine use and self medication differed. Urgent strategies to promote the rational use of drugs in this population and their families are necessary.
- Biomolecular Effects of Jb1 (an IGF-I Peptide Analog) in a Rat Model of Oxygen-Induced Retinopathy(2011) BROCK, Romy S.; GEBREKRISTOS, Bisrat H.; KUNIYOSHI, Katherine M.; MODANLOU, Houchang D.; FALCAO, Mario Cicero; BEHARRY, Kay D.Low-serum IGF-I levels at birth is a risk factor for the development of retinopathy of prematurity in extremely LBW infants. We tested the hypothesis that JB1 (an IGF-I analog) prevents oxygen-induced retinopathy in our rat model. Neonatal rats were exposed to 50% oxygen with brief, clustered, hypoxic (12%) episodes from birth to P14. The pups were treated with s.c. injections of 1) JB1 (1 mu g/d) on P1, P2, and P3 (JB1x3); 2) JB1 (1 mu g/d) on alternate days from P1 to P13 (JB1x7); or 3) equivalent volume saline. Control littermates were raised in room air (RA) with all conditions identical except for inspired O-2. Groups were analyzed after hyperoxia/hypoxia (H/H) cycling at P14 or allowed to recover in RA until P21. Systemic and ocular VEGF, soluble VEGFR-1, and IGF-I; retinal vasculature; and gene profile of retinal angiogenesis were assessed. JB1x3 was more effective with associated increases in sVEGFR-1 and decreased retinal pathologies than JB1x7. We conclude that early short-term exposure to systemic JB1 treatment normalizes retinal abnormalities seen with H/H cycling, an effect that may involve sVEGFR-1. (Pediatr Res 69: 135-141, 2011)
- TEACHING IN MEDICAL RESIDENCY IN TIMES OF COVID-19(2020) FALCÃO, Mário Cícero; FONSECA, Camila Dal Piccolo Pracchia; DANTI, Gabriel Vecchi
bookPart Nutrição parenteral do recém-nascido(2022) FEFERBAUM, Rubens; BIGIO, Juliana Zoboli del; FALCãO, Mário Cícero; HAGA, Cristiane