Aging, Diabetes, and Hypertension Are Associated With Decreased Nasal Mucociliary Clearance

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorOLIVEIRA-MAUL, Janaina Proenca de
dc.contributor.authorCARVALHO, Heraclito Barbosa de
dc.contributor.authorGOTO, Danielle Miyuki
dc.contributor.authorMAIA, Raphaela Mendonca
dc.contributor.authorFLO, Claudia
dc.contributor.authorBARNABE, Viviane
dc.contributor.authorFRANCO, Denise Reis
dc.contributor.authorBENABOU, Simon
dc.contributor.authorPERRACINI, Monica Rodrigues
dc.contributor.authorJACOB-FILHO, Wilson
dc.contributor.authorSALDIVA, Paulo Hilario Nascimento
dc.contributor.authorLORENZI-FILHO, Geraldo
dc.contributor.authorRUBIN, Bruce K.
dc.contributor.authorNAKAGAWA, Naomi Kondo
dc.date.accessioned2013-09-23T16:43:47Z
dc.date.available2013-09-23T16:43:47Z
dc.date.issued2013
dc.description.abstractBackground: We showed previously that nasal mucociliary clearance was decreased in critically ill elderly subjects, most of whom had diabetes mellitus (DM) and/or hypertension (HTN). To determine if these changes were due to the effects of aging, disease, or critical illness, we studied nasal mucociliary clearance and mucus properties in an ambulatory population consisting of young, elderly, and healthy subjects and those with DM, HTN, or both. Methods: Of 440 subjects contacted, 252 entered the study. The subjects were divided into the following groups: (1) healthy (n = 79, 18-94 years, 50 men) and (2) DM and/or HTN, of which 37 had DM (14-90 years, 12 men), 52 had HTN (23-90 years, 12 men), and 84 had both DM and HTN (25-82 years, 33 men). Subjects were also grouped by age: < 40 years, 40 to 59 years, and >= 60 years. We assessed demographic and clinical data, quality of life using the 36-Item Short Form Health Survey (SF-36) questionnaire, nasal mucociliary clearance using the saccharine transit test (STT), and in vitro mucus properties by examining the sneeze (high airflow) clear-ability and contact angle. A logistic regression analysis for prolonged STT > 12 min was used, and we controlled for age, sex, and diseases. Results: Subjects aged > 60 years reported a decreased SF-36 physical component relative to other age groups. Sex, BMI, BP, heart rate, pulse oximetry, blood glucose level, and mucus properties were not associated with prolonged STT. Aging and DM and/or HTN independently increased the risk of prolonged STT. Conclusions: Aging and DM, HTN, or both diseases are independently associated with decreased nasal mucociliary clearance. This may predispose toward respiratory infections.
dc.description.indexMEDLINE
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo [FAPESP 07/51605-9]
dc.description.sponsorshipVirginia Commonwealth University Office of Research
dc.description.sponsorshipDenny Hamlin Foundation
dc.description.sponsorshipCystic Fibrosis Foundation
dc.description.sponsorshipFisher&Paykel Healthcare
dc.description.sponsorshipMcNeil Laboratories
dc.description.sponsorshipTeleflex Medical
dc.description.sponsorshipGlaxoSmithKline
dc.description.sponsorshipGilead Sciences, Inc
dc.description.sponsorshipReckitt Benckiser Pharmaceuticals
dc.identifier.citationCHEST, v.143, n.4, p.1091-1097, 2013
dc.identifier.doi10.1378/chest.12-1183
dc.identifier.issn0012-3692
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/2102
dc.language.isoeng
dc.publisherAMER COLL CHEST PHYSICIANS
dc.relation.ispartofChest
dc.rightsrestrictedAccess
dc.rights.holderCopyright AMER COLL CHEST PHYSICIANS
dc.subject.otherciliary beat frequency
dc.subject.othercommunity-acquired-pneumonia
dc.subject.otherhigh blood-pressure
dc.subject.othercystic-fibrosis
dc.subject.otherpulmonary-function
dc.subject.otherreference values
dc.subject.otherhealth survey
dc.subject.otherolder-adults
dc.subject.otherage
dc.subject.otherpopulation
dc.subject.wosCritical Care Medicine
dc.subject.wosRespiratory System
dc.titleAging, Diabetes, and Hypertension Are Associated With Decreased Nasal Mucociliary Clearance
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryisous
hcfmusp.author.externalOLIVEIRA-MAUL, Janaina Proenca de:Univ Sao Paulo, Fac Med, Inst Heart, Dept Physiotherapy Commun Sci & Disorders,LIM 34, BR-01246903 Sao Paulo, Brazil; Univ Sao Paulo, Fac Med, Inst Heart, Dept Pathol,LIM 05, BR-01246903 Sao Paulo, Brazil
hcfmusp.author.externalMAIA, Raphaela Mendonca:Univ Sao Paulo City, Master Sci Program Physiotherapy, Sao Paulo, Brazil
hcfmusp.author.externalFLO, Claudia:Univ Sao Paulo, Fac Med, Inst Heart, Dept Geriatr, BR-01246903 Sao Paulo, Brazil
hcfmusp.author.externalBARNABE, Viviane:Univ Sao Paulo, Fac Med, Inst Heart, Dept Physiotherapy Commun Sci & Disorders,LIM 34, BR-01246903 Sao Paulo, Brazil; Univ Sao Paulo, Fac Med, Inst Heart, Dept Pathol,LIM 05, BR-01246903 Sao Paulo, Brazil
hcfmusp.author.externalFRANCO, Denise Reis:Assoc Diabet Juvenil, Sao Paulo, Brazil
hcfmusp.author.externalPERRACINI, Monica Rodrigues:Univ Sao Paulo City, Master Sci Program Physiotherapy, Sao Paulo, Brazil
hcfmusp.author.externalRUBIN, Bruce K.:Virginia Commonwealth Univ, Dept Pediat, Richmond, VA USA; Virginia Commonwealth Univ, Childrens Hosp Richmond, Richmond, VA USA
hcfmusp.citation.scopus57
hcfmusp.contributor.author-fmusphcHERACLITO BARBOSA DE CARVALHO
hcfmusp.contributor.author-fmusphcDANIELLE MIYUKI GOTO
hcfmusp.contributor.author-fmusphcSIMON BENABOU
hcfmusp.contributor.author-fmusphcWILSON JACOB FILHO
hcfmusp.contributor.author-fmusphcPAULO HILARIO NASCIMENTO SALDIVA
hcfmusp.contributor.author-fmusphcGERALDO LORENZI FILHO
hcfmusp.contributor.author-fmusphcNAOMI KONDO NAKAGAWA
hcfmusp.description.beginpage1091
hcfmusp.description.endpage1097
hcfmusp.description.issue4
hcfmusp.description.volume143
hcfmusp.origemWOS
hcfmusp.origem.pubmed23100111
hcfmusp.origem.scopus2-s2.0-84876010682
hcfmusp.origem.wosWOS:000317871500033
hcfmusp.publisher.cityNORTHBROOK
hcfmusp.publisher.countryUSA
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hcfmusp.remissive.sponsorshipFAPESP
hcfmusp.remissive.sponsorshipGlaxoSmithKline
hcfmusp.remissive.sponsorshipGilead
hcfmusp.scopus.lastupdate2024-04-12
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