Aging, Diabetes, and Hypertension Are Associated With Decreased Nasal Mucociliary Clearance
Carregando...
Citações na Scopus
58
Tipo de produção
article
Data de publicação
2013
Título da Revista
ISSN da Revista
Título do Volume
Editora
AMER COLL CHEST PHYSICIANS
Autores
OLIVEIRA-MAUL, Janaina Proenca de
MAIA, Raphaela Mendonca
FLO, Claudia
BARNABE, Viviane
FRANCO, Denise Reis
PERRACINI, Monica Rodrigues
Citação
CHEST, v.143, n.4, p.1091-1097, 2013
Resumo
Background: We showed previously that nasal mucociliary clearance was decreased in critically ill elderly subjects, most of whom had diabetes mellitus (DM) and/or hypertension (HTN). To determine if these changes were due to the effects of aging, disease, or critical illness, we studied nasal mucociliary clearance and mucus properties in an ambulatory population consisting of young, elderly, and healthy subjects and those with DM, HTN, or both. Methods: Of 440 subjects contacted, 252 entered the study. The subjects were divided into the following groups: (1) healthy (n = 79, 18-94 years, 50 men) and (2) DM and/or HTN, of which 37 had DM (14-90 years, 12 men), 52 had HTN (23-90 years, 12 men), and 84 had both DM and HTN (25-82 years, 33 men). Subjects were also grouped by age: < 40 years, 40 to 59 years, and >= 60 years. We assessed demographic and clinical data, quality of life using the 36-Item Short Form Health Survey (SF-36) questionnaire, nasal mucociliary clearance using the saccharine transit test (STT), and in vitro mucus properties by examining the sneeze (high airflow) clear-ability and contact angle. A logistic regression analysis for prolonged STT > 12 min was used, and we controlled for age, sex, and diseases. Results: Subjects aged > 60 years reported a decreased SF-36 physical component relative to other age groups. Sex, BMI, BP, heart rate, pulse oximetry, blood glucose level, and mucus properties were not associated with prolonged STT. Aging and DM and/or HTN independently increased the risk of prolonged STT. Conclusions: Aging and DM, HTN, or both diseases are independently associated with decreased nasal mucociliary clearance. This may predispose toward respiratory infections.
Palavras-chave
Referências
- Agius AM, 1998, CLIN OTOLARYNGOL, V23, P227
- Albers GM, 1996, J APPL PHYSIOL, V81, P2690
- Alper AB, 2005, HYPERTENSION, V45, P34, DOI 10.1161/01.HYP.0000150783.79172.bb
- American Diabetes Association, 2012, DIABETES CARE S1, V35, pS64, DOI 10.2337/DC12-S064
- ANDERSEN I, 1974, ARCH ENVIRON HEALTH, V29, P290
- Antonini JM, 2001, CHEST, V120, P240, DOI 10.1378/chest.120.1.240
- Aquino ES, 2012, RESP CARE, V57, P1914, DOI 10.4187/respcare.01705
- Armengot M, 1993, An Otorrinolaringol Ibero Am, V20, P581
- Britto RR, 2009, GERONTOLOGY, V55, P505, DOI 10.1159/000235853
- Castellanos Mario R, 2010, Int Arch Med, V3, P16, DOI 10.1186/1755-7682-3-16
- Chobanian AV, 2003, HYPERTENSION, V42, P1206, DOI 10.1161/01.HYP.0000107251.49515.c2
- Daviskas E, 2010, CHEST, V137, P861, DOI 10.1378/chest.09-2017
- Denti L, 2010, J AM GERIATR SOC, V58, P12, DOI 10.1111/j.1532-5415.2009.02616.x
- DOYLE W J, 1987, Rhinology (Utrecht), V25, P167
- Ehrlich SF, 2010, DIABETES CARE, V33, P55, DOI 10.2337/dc09-0880
- ENRIGHT PL, 1993, AM REV RESPIR DIS, V147, P125
- GOLHAR S, 1986, J LARYNGOL OTOL, V100, P533, DOI 10.1017/S0022215100099631
- GOODMAN RM, 1978, AM REV RESPIR DIS, V117, P205
- Goto DM, 2010, RESP PHYSIOL NEUROBI, V170, P246, DOI 10.1016/j.resp.2010.01.013
- Goto DM, 2011, ENVIRON RES, V111, P664, DOI 10.1016/j.envres.2011.03.006
- Ho JC, 2001, AM J RESP CRIT CARE, V163, P983
- Hoyert Donna L, 2005, Natl Vital Stat Rep, V53, P1
- JENKINSON C, 1993, BRIT MED J, V306, P1437
- KAO CH, 1994, CLIN NUCL MED, V19, P813, DOI 10.1097/00003072-199409000-00015
- Kesimci E, 2008, MINERVA ANESTESIOL, V74, P107
- Khambalia A, 2011, BMC PUBLIC HEALTH, V11, DOI 10.1186/1471-2458-11-719
- KONRAD F, 1994, CHEST, V105, P237, DOI 10.1378/chest.105.1.237
- Logan Alexander G, 2011, Expert Rev Cardiovasc Ther, V9, P113, DOI 10.1586/erc.10.171
- Maruyama T, 2010, RESP MED, V104, P584, DOI 10.1016/j.rmed.2009.12.008
- Meyer Keith C, 2005, Proc Am Thorac Soc, V2, P433, DOI 10.1513/pats.200508-081JS
- MIDDLETON PG, 1993, THORAX, V48, P812, DOI 10.1136/thx.48.8.812
- MORIARTY B G, 1991, Rhinology (Utrecht), V29, P173
- Nakagawa NK, 2005, CHEST, V128, P2772, DOI 10.1378/chest.128.4.2772
- Nylen ES, 2010, J AM GERIATR SOC, V58, P1850, DOI 10.1111/j.1532-5415.2010.03068.x
- PAVIA D, 1986, THORAX, V41, P301, DOI 10.1136/thx.41.4.301
- PUCHELLE E, 1981, ACTA OTO-LARYNGOL, V91, P297, DOI 10.3109/00016488109138511
- PUCHELLE E, 1979, SCAND J RESPIR DIS, V60, P307
- Rosano C, 2011, J AM GERIATR SOC, V59, P390, DOI 10.1111/j.1532-5415.2010.03282.x
- RUTLAND J, 1981, THORAX, V36, P654, DOI 10.1136/thx.36.9.654
- SACHDEVA A, 1993, INDIAN J MED RES-B, V98, P265
- SAKAKURA Y, 1983, ACTA OTO-LARYNGOL, V96, P167, DOI 10.3109/00016488309132888
- Selvin E, 2006, DIABETES CARE, V29, P2415, DOI 10.2337/dc06-1058
- STEWART AL, 1988, MED CARE, V26, P724, DOI 10.1097/00005650-198807000-00007
- Svartengren M, 2005, EUR RESPIR J, V26, P609, DOI 10.1183/09031936.05.00002105
- Valencia M, 2007, CHEST, V132, P515, DOI 10.1378/chest.07-0306
- Valia PP, 2008, ARCH BRONCONEUMOL, V44, P540, DOI 10.1016/S1579-2129(08)60100-7
- Yadav J, 2001, INT J PEDIATR OTORHI, V57, P21, DOI 10.1016/S0165-5876(00)00429-8
- YAGER JA, 1980, AM REV RESPIR DIS, V121, P661
Coleções
Artigos e Materiais de Revistas Científicas - FM/MPR
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - FM/MFT
Artigos e Materiais de Revistas Científicas - FM/MPT
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/InCor
Carregar mais Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - FM/MFT
Artigos e Materiais de Revistas Científicas - FM/MPT
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/InCor